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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARIH1

Summary for ARIH1

Gene information	Gene symbol	ARIH1
	Ensembl ID	ENSG00000166233
	Entrez ID	25820
	Gene name	ariadne RBR E3 ubiquitin protein ligase 1
	Synonyms	ARI\|HARI\|HHARI\|UBCH7BP
	Gene type	protein_coding
	UniProtAcc	Q9Y4X5

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Dataset with differentially expressed gene: ARIH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.260871	2.06e-10
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.362407	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.292374	1.38e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.383927	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.371778	1.21e-27

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Expression of ARIH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARIH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARIH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARIH1	hsa-miR-6502-5p	88.4144	NM_005744
ARIH1	hsa-miR-4693-5p	88.3273	NM_005744
ARIH1	hsa-miR-3120-3p	88.2857	NM_005744
ARIH1	hsa-miR-3139	88.1571	NM_005744
ARIH1	hsa-miR-5684	87.9114	NM_005744
ARIH1	hsa-miR-6791-3p	87.1935	NM_005744
ARIH1	hsa-miR-6829-3p	87.1935	NM_005744
ARIH1	hsa-miR-3133	86.4621	NM_005744
ARIH1	hsa-miR-4318	85.9746	NM_005744
ARIH1	hsa-miR-877-3p	85.9257	NM_005744
ARIH1	hsa-miR-338-5p	85.6234	NM_005744
ARIH1	hsa-miR-216b-3p	85.5207	NM_005744
ARIH1	hsa-miR-708-5p	84.765	NM_005744
ARIH1	hsa-miR-28-5p	84.765	NM_005744
ARIH1	hsa-miR-590-3p	84.5089	NM_005744
ARIH1	hsa-miR-6853-3p	83.3783	NM_005744
ARIH1	hsa-miR-4733-5p	83.0576	NM_005744
ARIH1	hsa-miR-452-5p	83.0207	NM_005744
ARIH1	hsa-miR-892c-3p	83.0207	NM_005744
ARIH1	hsa-miR-4676-3p	83.0207	NM_005744
ARIH1	hsa-miR-6882-3p	82.8933	NM_005744
ARIH1	hsa-miR-4266	82.5987	NM_005744
ARIH1	hsa-miR-29a-5p	82.2343	NM_005744
ARIH1	hsa-miR-642a-5p	82.1566	NM_005744
ARIH1	hsa-miR-107	81.9741	NM_005744
ARIH1	hsa-miR-103a-3p	81.9741	NM_005744
ARIH1	hsa-miR-6852-3p	81.9196	NM_005744
ARIH1	hsa-miR-5581-3p	81.9034	NM_005744
ARIH1	hsa-miR-544b	81.7135	NM_005744
ARIH1	hsa-miR-556-3p	81.2435	NM_005744
ARIH1	hsa-miR-3909	80.3275	NM_005744
ARIH1	hsa-miR-4668-5p	80.2815	NM_005744
ARIH1	hsa-miR-3942-3p	80.2004	NM_005744
ARIH1	hsa-miR-1265	80.0725	NM_005744
ARIH1	hsa-miR-4482-3p	80.0554	NM_005744
ARIH1	hsa-miR-12122	80.0475	NM_005744

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Motifs and transcription factors (TFs) regulating ARIH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARIH1	metacluster_135.11	NR2C2 (directAnnotation).
ARIH1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARIH1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARIH1	metacluster_7.13	ZFX (directAnnotation).
ARIH1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARIH1	cisbp__M00968	MTF2 (directAnnotation).
ARIH1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARIH1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARIH1	cisbp__M00341	PAX6 (directAnnotation).
ARIH1	metacluster_198.3	ZFP64 (directAnnotation).
ARIH1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARIH1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARIH1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARIH1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARIH1	cisbp__M00788	ZFY (inferredBy_Orthology).
ARIH1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ARIH1	metacluster_175.1	ZNF283 (directAnnotation).
ARIH1	hdpi__ZNF304	ZNF304 (directAnnotation).
ARIH1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARIH1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ARIH1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARIH1	transfac_pro__M01199	TRIM28 (directAnnotation).
ARIH1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ARIH1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARIH1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARIH1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARIH1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARIH1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ARIH1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARIH1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ARIH1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ARIH1	jaspar__MA1721.1	ZNF93 (directAnnotation).
ARIH1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ARIH1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ARIH1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ARIH1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ARIH1	transfac_pro__M01253	CNOT3 (directAnnotation).
ARIH1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ARIH1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ARIH1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ARIH1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ARIH1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ARIH1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ARIH1	jaspar__MA0748.2	YY2 (directAnnotation).
ARIH1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ARIH1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ARIH1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ARIH1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ARIH1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ARIH1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."