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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARID4A

Summary for ARID4A

Gene information	Gene symbol	ARID4A
	Ensembl ID	ENSG00000032219
	Entrez ID	5926
	Gene name	AT-rich interaction domain 4A
	Synonyms	RBBP1\|RBP-1\|RBP1
	Gene type	protein_coding
	UniProtAcc	P29374

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Dataset with differentially expressed gene: ARID4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.285358	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.409825	1.07e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.257034	9.81e-30
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.438765	7.08e-19

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Expression of ARID4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARID4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARID4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARID4A	hsa-miR-302e	90.187	NM_002892
ARID4A	hsa-miR-3160-5p	90.0595	NM_002892
ARID4A	hsa-miR-3168	89.9738	NM_002892
ARID4A	hsa-miR-4646-3p	89.9694	NM_002892
ARID4A	hsa-miR-153-5p	89.4514	NM_023000
ARID4A	hsa-miR-6859-5p	88.8494	NM_023000
ARID4A	hsa-miR-3916	88.8494	NM_023000
ARID4A	hsa-miR-3125	88.8494	NM_023000
ARID4A	hsa-miR-5002-3p	88.7105	NM_002892
ARID4A	hsa-miR-9983-3p	88.381	NM_002892
ARID4A	hsa-miR-3944-5p	88.3211	NM_002892
ARID4A	hsa-miR-302b-3p	88.2372	NM_002892
ARID4A	hsa-miR-302c-3p	88.2372	NM_002892
ARID4A	hsa-miR-302d-3p	88.2372	NM_002892
ARID4A	hsa-miR-302a-3p	88.2372	NM_002892
ARID4A	hsa-let-7a-3p	88.0313	NM_023000
ARID4A	hsa-let-7b-3p	88.0313	NM_023000
ARID4A	hsa-miR-98-3p	88.0313	NM_023000
ARID4A	hsa-let-7f-1-3p	88.0313	NM_023000
ARID4A	hsa-miR-3921	88.0185	NM_023000
ARID4A	hsa-miR-4653-5p	88.0185	NM_023000
ARID4A	hsa-miR-205-3p	87.1498	NM_023000
ARID4A	hsa-miR-520d-3p	86.9859	NM_002892
ARID4A	hsa-miR-520b-3p	86.9859	NM_002892
ARID4A	hsa-miR-520e-3p	86.9859	NM_002892
ARID4A	hsa-miR-520c-3p	86.9859	NM_002892
ARID4A	hsa-miR-372-3p	86.9859	NM_002892
ARID4A	hsa-miR-373-3p	86.9859	NM_002892
ARID4A	hsa-miR-520a-3p	86.9859	NM_002892
ARID4A	hsa-miR-6857-5p	86.756	NM_023000
ARID4A	hsa-miR-450b-5p	86.6638	NM_002892
ARID4A	hsa-let-7c-3p	86.4827	NM_002892
ARID4A	hsa-miR-3190-3p	86.254	NM_002892
ARID4A	hsa-miR-511-5p	85.9155	NM_023000
ARID4A	hsa-miR-5196-5p	85.8393	NM_023000
ARID4A	hsa-miR-4747-5p	85.8393	NM_023000
ARID4A	hsa-miR-583	85.7546	NM_023000
ARID4A	hsa-miR-3662	85.7044	NM_023000
ARID4A	hsa-miR-6788-5p	85.698	NM_023000
ARID4A	hsa-miR-30c-2-3p	85.698	NM_023000
ARID4A	hsa-miR-30c-1-3p	85.698	NM_023000
ARID4A	hsa-miR-548f-3p	85.2641	NM_023000
ARID4A	hsa-miR-548e-3p	85.2641	NM_023000
ARID4A	hsa-miR-548ar-3p	85.2641	NM_023000
ARID4A	hsa-miR-548bc	85.2641	NM_023000
ARID4A	hsa-miR-548az-3p	85.2641	NM_023000
ARID4A	hsa-miR-548a-3p	84.9541	NM_023000
ARID4A	hsa-miR-4477a	84.9369	NM_002892
ARID4A	hsa-miR-129-5p	84.8186	NM_002892
ARID4A	hsa-miR-4798-3p	84.7543	NM_002892

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Motifs and transcription factors (TFs) regulating ARID4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARID4A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARID4A	transfac_pro__M07397	ZNF148 (directAnnotation).
ARID4A	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ARID4A	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ARID4A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ARID4A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ARID4A	metacluster_7.13	ZFX (directAnnotation).
ARID4A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ARID4A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ARID4A	transfac_pro__M01175	ZBTB7B (directAnnotation).
ARID4A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARID4A	tfdimers__MD00151	CHURC1 (directAnnotation).
ARID4A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ARID4A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ARID4A	transfac_pro__M01303	SP1 (directAnnotation).
ARID4A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARID4A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ARID4A	transfac_pro__M02090	E2F4 (directAnnotation).
ARID4A	transfac_pro__M01714	KLF15 (directAnnotation).
ARID4A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ARID4A	transfac_pro__M02089	E2F3 (directAnnotation).
ARID4A	metacluster_3.14	WT1; WT1 (directAnnotation).
ARID4A	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ARID4A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ARID4A	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ARID4A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ARID4A	cisbp__M07938	E2F1 (directAnnotation).
ARID4A	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
ARID4A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ARID4A	transfac_pro__M07436	WT1 (directAnnotation).
ARID4A	transfac_pro__M02281	SP1 (directAnnotation).
ARID4A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARID4A	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
ARID4A	transfac_pro__M02898	SMAD3 (directAnnotation).
ARID4A	transfac_public__M00491	PATZ1 (directAnnotation).
ARID4A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ARID4A	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ARID4A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ARID4A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARID4A	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
ARID4A	transfac_pro__M12686	ZBTB10 (directAnnotation).
ARID4A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ARID4A	metacluster_143.14	ZNF320 (directAnnotation).
ARID4A	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
ARID4A	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
ARID4A	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARID4A	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ARID4A	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ARID4A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARID4A	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."