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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARID3B

Summary for ARID3B

Gene information	Gene symbol	ARID3B
	Ensembl ID	ENSG00000179361
	Entrez ID	10620
	Gene name	AT-rich interaction domain 3B
	Synonyms	BDP\|DRIL2
	Gene type	protein_coding
	UniProtAcc	Q8IVW6

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Dataset with differentially expressed gene: ARID3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.357057	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.255484	0.00e+00

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Expression of ARID3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARID3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARID3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARID3B	hsa-miR-3926	86.5462	NM_001307939
ARID3B	hsa-miR-4426	86.2898	NM_001307939
ARID3B	hsa-miR-6852-5p	86.272	NM_001307939
ARID3B	hsa-miR-7160-5p	86.0433	NM_001307939
ARID3B	hsa-miR-4271	86.0284	NM_001307939
ARID3B	hsa-miR-7976	85.216	NM_001307939
ARID3B	hsa-miR-3189-5p	84.088	NM_001307939
ARID3B	hsa-miR-4505	83.4182	NM_001307939
ARID3B	hsa-miR-6799-3p	83.3283	NM_001307939
ARID3B	hsa-miR-3173-5p	83.3283	NM_001307939
ARID3B	hsa-miR-4662a-3p	82.959	NM_001307939
ARID3B	hsa-miR-1226-5p	82.9139	NM_001307939
ARID3B	hsa-miR-5787	82.7319	NM_001307939
ARID3B	hsa-miR-548s	82.4434	NM_001307939
ARID3B	hsa-miR-3619-5p	82.4055	NM_001307939
ARID3B	hsa-miR-3169	81.4324	NM_001307939
ARID3B	hsa-miR-3200-5p	81.3305	NM_001307939
ARID3B	hsa-miR-214-3p	81.1232	NM_001307939
ARID3B	hsa-miR-761	81.1232	NM_001307939
ARID3B	hsa-miR-3907	81.0119	NM_001307939
ARID3B	hsa-miR-4789-3p	80.4161	NM_001307939
ARID3B	hsa-miR-1587	80.308	NM_001307939

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Motifs and transcription factors (TFs) regulating ARID3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARID3B	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ARID3B	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ARID3B	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
ARID3B	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ARID3B	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ARID3B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ARID3B	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ARID3B	metacluster_3.14	WT1; WT1 (directAnnotation).
ARID3B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ARID3B	cisbp__M07938	E2F1 (directAnnotation).
ARID3B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARID3B	cisbp__M00249	WT1 (directAnnotation).
ARID3B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARID3B	transfac_pro__M01122	ZNF219 (directAnnotation).
ARID3B	metacluster_151.2	ZNF23 (directAnnotation).
ARID3B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARID3B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ARID3B	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ARID3B	metacluster_7.13	ZFX (directAnnotation).
ARID3B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ARID3B	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ARID3B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ARID3B	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ARID3B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARID3B	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ARID3B	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
ARID3B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARID3B	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
ARID3B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARID3B	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ARID3B	transfac_pro__M01253	CNOT3 (directAnnotation).
ARID3B	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ARID3B	metacluster_3.10	KLF2; KLF4 (directAnnotation).
ARID3B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ARID3B	jaspar__MA1721.1	ZNF93 (directAnnotation).
ARID3B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ARID3B	transfac_pro__M05479	ZNF580 (directAnnotation).
ARID3B	jaspar__MA1122.1	TFDP1 (directAnnotation).
ARID3B	cisbp__M00341	PAX6 (directAnnotation).
ARID3B	transfac_pro__M01199	TRIM28 (directAnnotation).
ARID3B	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ARID3B	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
ARID3B	tfdimers__MD00151	CHURC1 (directAnnotation).
ARID3B	tfdimers__MD00391	KLF4 (directAnnotation).
ARID3B	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
ARID3B	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
ARID3B	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
ARID3B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARID3B	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ARID3B	cisbp__M00968	MTF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."