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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARHGAP12

Summary for ARHGAP12

Gene information	Gene symbol	ARHGAP12
	Ensembl ID	ENSG00000165322
	Entrez ID	94134
	Gene name	Rho GTPase activating protein 12
	Synonyms	FLJ10971\|FLJ20737\|FLJ21785
	Gene type	protein_coding
	UniProtAcc	Q8IWW6

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Dataset with differentially expressed gene: ARHGAP12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.4575	1.34e-30

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Expression of ARHGAP12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARHGAP12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARHGAP12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARHGAP12	hsa-miR-365b-3p	91.5313	NM_001270695
ARHGAP12	hsa-miR-3681-3p	91.1176	NM_001270695
ARHGAP12	hsa-miR-5586-5p	90.4493	NM_001270695
ARHGAP12	hsa-miR-12136	90.3204	NM_001270695
ARHGAP12	hsa-miR-3692-3p	90.0319	NM_001270695
ARHGAP12	hsa-miR-607	89.8212	NM_001270695
ARHGAP12	hsa-miR-4719	89.1314	NM_001270695
ARHGAP12	hsa-miR-133a-3p	88.9832	NM_001270695
ARHGAP12	hsa-miR-133b	88.9832	NM_001270695
ARHGAP12	hsa-miR-3529-3p	88.9226	NM_001270695
ARHGAP12	hsa-let-7f-1-3p	88.1939	NM_001270695
ARHGAP12	hsa-let-7b-3p	88.1939	NM_001270695
ARHGAP12	hsa-miR-98-3p	88.1939	NM_001270695
ARHGAP12	hsa-let-7a-3p	88.1939	NM_001270695
ARHGAP12	hsa-miR-202-3p	88.0142	NM_001270695
ARHGAP12	hsa-miR-4422	87.8536	NM_001270695
ARHGAP12	hsa-miR-8081	87.321	NM_001270695
ARHGAP12	hsa-miR-766-5p	87.2151	NM_001270695
ARHGAP12	hsa-miR-4666a-3p	87.0823	NM_001270695
ARHGAP12	hsa-miR-5003-5p	86.8852	NM_001270695
ARHGAP12	hsa-miR-7856-5p	86.8658	NM_001270695
ARHGAP12	hsa-miR-499a-5p	86.388	NM_001270695
ARHGAP12	hsa-miR-497-5p	86.3756	NM_001270695
ARHGAP12	hsa-miR-15b-5p	86.3756	NM_001270695
ARHGAP12	hsa-miR-15a-5p	86.3756	NM_001270695
ARHGAP12	hsa-miR-195-5p	86.3756	NM_001270695
ARHGAP12	hsa-miR-424-5p	86.3756	NM_001270695
ARHGAP12	hsa-miR-6838-5p	86.3756	NM_001270695
ARHGAP12	hsa-miR-16-5p	86.3756	NM_001270695
ARHGAP12	hsa-miR-338-5p	85.8941	NM_001270695
ARHGAP12	hsa-miR-1468-3p	85.7521	NM_001270695
ARHGAP12	hsa-miR-381-3p	85.751	NM_001270695
ARHGAP12	hsa-miR-300	85.751	NM_001270695
ARHGAP12	hsa-miR-627-5p	85.5247	NM_001270695
ARHGAP12	hsa-miR-8087	85.3151	NM_001270695
ARHGAP12	hsa-miR-205-3p	84.9312	NM_001270695
ARHGAP12	hsa-miR-6504-3p	84.5195	NM_001270695
ARHGAP12	hsa-miR-10399-5p	84.5046	NM_001270695
ARHGAP12	hsa-miR-7-2-3p	83.9334	NM_001270695
ARHGAP12	hsa-miR-7-1-3p	83.9334	NM_001270695
ARHGAP12	hsa-miR-28-3p	83.8708	NM_001270695
ARHGAP12	hsa-miR-524-5p	83.7368	NM_001270695
ARHGAP12	hsa-miR-520d-5p	83.7368	NM_001270695
ARHGAP12	hsa-miR-5000-3p	83.3194	NM_001270695
ARHGAP12	hsa-miR-4436a	83.3194	NM_001270695
ARHGAP12	hsa-miR-5697	82.0887	NM_001270695
ARHGAP12	hsa-miR-12128	81.2168	NM_001270695
ARHGAP12	hsa-miR-6514-3p	80.8126	NM_001270695
ARHGAP12	hsa-miR-7976	80.2195	NM_001270695

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Motifs and transcription factors (TFs) regulating ARHGAP12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARHGAP12	metacluster_135.11	NR2C2 (directAnnotation).
ARHGAP12	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARHGAP12	tfdimers__MD00038	TFAP2C (directAnnotation).
ARHGAP12	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARHGAP12	metacluster_7.13	ZFX (directAnnotation).
ARHGAP12	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARHGAP12	cisbp__M00968	MTF2 (directAnnotation).
ARHGAP12	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARHGAP12	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARHGAP12	cisbp__M00341	PAX6 (directAnnotation).
ARHGAP12	metacluster_198.3	ZFP64 (directAnnotation).
ARHGAP12	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARHGAP12	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARHGAP12	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARHGAP12	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARHGAP12	cisbp__M00788	ZFY (inferredBy_Orthology).
ARHGAP12	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ARHGAP12	metacluster_175.1	ZNF283 (directAnnotation).
ARHGAP12	hdpi__ZNF304	ZNF304 (directAnnotation).
ARHGAP12	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARHGAP12	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ARHGAP12	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARHGAP12	transfac_pro__M01199	TRIM28 (directAnnotation).
ARHGAP12	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ARHGAP12	metacluster_151.2	ZNF23 (directAnnotation).
ARHGAP12	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGAP12	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARHGAP12	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARHGAP12	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."