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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: APP

Summary for APP

Gene information	Gene symbol	APP
	Ensembl ID	ENSG00000142192
	Entrez ID	351
	Gene name	amyloid beta precursor protein
	Synonyms	AD1\|alpha-sAPP
	Gene type	protein_coding
	UniProtAcc	P05067

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Dataset with differentially expressed gene: APP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.822104	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	1.02767	3.39e-14
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.330405	2.02e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.47995	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.277745	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.690927	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.413864	1.44e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.858468	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.581283	0.00e+00

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Expression of APP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Mono/Macro	Malignant cells	GSE161801_IMiD	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Progenitors	Malignant cells	GSE161801_IMiD	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	cDCs	Malignant cells	GSE161801_IMiD	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	Malignant cells	GSE161801_IMiD	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	B cells	Malignant cells	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Malignant cells	B cells	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	Malignant cells	CD4+ T cells	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	Malignant cells	CD8+ T cells	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Malignant cells	Malignant cells	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Malignant cells	Mono/Macro	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	Malignant cells	NK cells	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	Malignant cells	cDCs	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Malignant cells	cDCs	GSE161801_PI	post	resistant
APP	Malignant cells	CPI-SS080C81D37	APP_CD74	APP	CD74	False	cDCs	Malignant cells	GSE161801_PI	post	resistant
APP	pDCs	CPI-SS097A84265	APP_TNFRSF21	APP	TNFRSF21	False	B cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS0CB6F5575	APP_PLXNA4	APP	PLXNA4	False	B cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	B cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	B cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS097A84265	APP_TNFRSF21	APP	TNFRSF21	False	CD4+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS0CB6F5575	APP_PLXNA4	APP	PLXNA4	False	CD4+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	CD4+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	CD4+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS097A84265	APP_TNFRSF21	APP	TNFRSF21	False	Mono/Macro	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS0CB6F5575	APP_PLXNA4	APP	PLXNA4	False	Mono/Macro	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	Mono/Macro	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Mono/Macro	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS097A84265	APP_TNFRSF21	APP	TNFRSF21	False	Progenitors	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS0CB6F5575	APP_PLXNA4	APP	PLXNA4	False	Progenitors	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	Progenitors	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS097A84265	APP_TNFRSF21	APP	TNFRSF21	False	cDCs	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS0CB6F5575	APP_PLXNA4	APP	PLXNA4	False	cDCs	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	cDCs	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	cDCs	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	pDCs	B cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	B cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	pDCs	CD4+ T cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	CD4+ T cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	pDCs	CD8+ T cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	CD8+ T cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS0F66EA6BE	APP_FPR2	APP	FPR2	False	pDCs	Mono/Macro	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	pDCs	Mono/Macro	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	Mono/Macro	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	pDCs	NK cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	NK cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	Plasma cells	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	Progenitors	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS07ACDDCD6	APP_SORL1	APP	SORL1	False	pDCs	cDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS080C81D37	APP_CD74	APP	CD74	False	pDCs	cDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS097A84265	APP_TNFRSF21	APP	TNFRSF21	False	pDCs	pDCs	GSE169246_PacBlood	pre	resistant
APP	pDCs	CPI-SS0CB6F5575	APP_PLXNA4	APP	PLXNA4	False	pDCs	pDCs	GSE169246_PacBlood	pre	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
APP	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating APP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APP	hsa-miR-144-3p	83.6896	NM_000484
APP	hsa-miR-4775	82.2942	NM_000484
APP	hsa-miR-8079	82.1779	NM_000484
APP	hsa-miR-337-3p	81.9616	NM_000484
APP	hsa-miR-3662	80.8004	NM_000484
APP	hsa-miR-298	80.1802	NM_000484

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Motifs and transcription factors (TFs) regulating APP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APP	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
APP	jaspar__MA1483.2	ELF2 (directAnnotation).
APP	metacluster_151.2	ZNF23 (directAnnotation).
APP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
APP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
APP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
APP	hdpi__ETV4	ETV4 (directAnnotation).
APP	jaspar__MA0748.2	YY2 (directAnnotation).
APP	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
APP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
APP	jaspar__MA0079.5	SP1 (directAnnotation).
APP	transfac_pro__M04826	EP300 (directAnnotation).
APP	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
APP	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
APP	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
APP	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
APP	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
APP	metacluster_35.7	HINFP (inferredBy_Orthology).
APP	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
APP	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
APP	hdpi__FLI1	FLI1 (directAnnotation).
APP	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
APP	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
APP	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
APP	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
APP	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
APP	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
APP	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
APP	metacluster_22.13	MAFK (inferredBy_Orthology).
APP	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
APP	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
APP	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
APP	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
APP	metacluster_22.15	BACH1 (directAnnotation).
APP	metacluster_22.14	BACH1 (inferredBy_Orthology).
APP	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
APP	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
APP	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
APP	transfac_pro__M05965	ZNF175 (directAnnotation).
APP	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
APP	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
APP	transfac_pro__M06786	ZNF646 (directAnnotation).
APP	metacluster_26.10	SOX21; SOX7; SOX8 (directAnnotation).
APP	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
APP	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
APP	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
APP	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
APP	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
APP	metacluster_196.7	POLR3A (directAnnotation).
APP	transfac_pro__M06516	ZNF418 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
APP	"Aducanumab"	DB12274	biotech
APP	"Aluminium phosphate"	DB14517	small molecule
APP	"Aluminium"	DB01370	small molecule
APP	"Aluminum acetate"	DB14518	small molecule
APP	"CAD106"	DB05150	small molecule
APP	"Copper"	DB09130	small molecule
APP	"Deferoxamine"	DB00746	small molecule
APP	"Dimercaprol"	DB06782	small molecule
APP	"Edonerpic"	DB05938	small molecule
APP	"Florbetaben (18F)"	DB09148	small molecule
APP	"Florbetapir (18F)"	DB09149	small molecule
APP	"Flutemetamol (18F)"	DB09151	small molecule
APP	"Gantenerumab"	DB12034	biotech
APP	"L-methionine (R)-S-oxide"	DB02235	small molecule
APP	"Lecanemab"	DB14580	biotech
APP	"Mito-4509"	DB05846	small molecule
APP	"Phenserine"	DB04892	small molecule
APP	"Resveratrol"	DB02709	small molecule
APP	"Tetrathiomolybdate"	DB05088	small molecule
APP	"Tromethamine"	DB03754	small molecule
APP	"Zinc acetate"	DB14487	small molecule
APP	"Zinc chloride"	DB14533	small molecule
APP	"Zinc sulfate, unspecified form"	DB14548	small molecule
APP	"Zinc"	DB01593	small molecule

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