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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: ANKS1A

Summary for ANKS1A

Gene informationGene symbol

ANKS1A

Ensembl ID

ENSG00000064999

Entrez ID

23294

Gene nameankyrin repeat and sterile alpha motif domain containing 1A
SynonymsANKS1|KIAA0229
Gene typeprotein_coding
UniProtAcc

Q92625


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Dataset with differentially expressed gene: ANKS1A

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells0.3235170.00e+00

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Expression of ANKS1A in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ANKS1A

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKS1A

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ANKS1Ahsa-miR-487a-5p86.3386NM_015245
ANKS1Ahsa-miR-472986.2183NM_015245
ANKS1Ahsa-miR-144-3p86.0487NM_015245
ANKS1Ahsa-miR-6838-5p85.9559NM_015245
ANKS1Ahsa-miR-497-5p85.9559NM_015245
ANKS1Ahsa-miR-424-5p85.9559NM_015245
ANKS1Ahsa-miR-998585.5437NM_015245
ANKS1Ahsa-miR-27a-3p85.5437NM_015245
ANKS1Ahsa-miR-27b-3p85.5437NM_015245
ANKS1Ahsa-miR-6807-5p85.4699NM_015245
ANKS1Ahsa-miR-442784.8579NM_015245
ANKS1Ahsa-let-7a-2-3p84.4606NM_015245
ANKS1Ahsa-miR-4652-3p84.3805NM_015245
ANKS1Ahsa-miR-570384.2354NM_015245
ANKS1Ahsa-miR-449b-5p84.1525NM_015245
ANKS1Ahsa-miR-34c-5p84.1525NM_015245
ANKS1Ahsa-miR-569783.2718NM_015245
ANKS1Ahsa-miR-613483.0826NM_015245
ANKS1Ahsa-let-7f-2-3p82.9952NM_015245
ANKS1Ahsa-miR-1185-2-3p82.9952NM_015245
ANKS1Ahsa-miR-1185-1-3p82.9952NM_015245
ANKS1Ahsa-miR-120582.9641NM_015245
ANKS1Ahsa-miR-548au-3p82.5797NM_015245
ANKS1Ahsa-miR-4777-3p82.1555NM_015245
ANKS1Ahsa-miR-4524b-5p82.1474NM_015245
ANKS1Ahsa-miR-4524a-5p82.1474NM_015245
ANKS1Ahsa-let-7g-3p82.0813NM_015245
ANKS1Ahsa-miR-426381.3742NM_015245
ANKS1Ahsa-miR-6739-5p81.251NM_015245
ANKS1Ahsa-miR-6733-5p81.251NM_015245
ANKS1Ahsa-miR-474481.132NM_015245
ANKS1Ahsa-miR-3189-5p81.0439NM_015245
ANKS1Ahsa-miR-365280.5095NM_015245
ANKS1Ahsa-miR-365a-3p80.4737NM_015245
ANKS1Ahsa-miR-365b-3p80.4737NM_015245
ANKS1Ahsa-miR-503-5p80.1919NM_015245
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Motifs and transcription factors (TFs) regulating ANKS1A

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ANKS1Ataipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
ANKS1Ataipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAPETV5; HES7 (directAnnotation).
ANKS1Akznf__ZFP57_Imbeault2017_RP_ChIP-seqZFP57 (directAnnotation).
ANKS1Aswissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."