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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD52

Summary for ANKRD52

Gene information	Gene symbol	ANKRD52
	Ensembl ID	ENSG00000139645
	Entrez ID	283373
	Gene name	ankyrin repeat domain 52
	Synonyms	FLJ34236\|PP6-ARS-C
	Gene type	protein_coding
	UniProtAcc	Q8NB46

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Dataset with differentially expressed gene: ANKRD52

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.412528	0.00e+00

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Expression of ANKRD52 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD52

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD52

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD52	hsa-miR-1248	85.5485	NM_173595
ANKRD52	hsa-miR-6513-3p	85.1592	NM_173595
ANKRD52	hsa-miR-19a-5p	85.0983	NM_173595
ANKRD52	hsa-miR-19b-2-5p	85.0983	NM_173595
ANKRD52	hsa-miR-19b-1-5p	85.0983	NM_173595
ANKRD52	hsa-miR-4516	84.6581	NM_173595
ANKRD52	hsa-miR-4428	84.4278	NM_173595
ANKRD52	hsa-miR-4671-3p	84.3181	NM_173595
ANKRD52	hsa-miR-210-5p	84.2104	NM_173595
ANKRD52	hsa-miR-1297	84.0843	NM_173595
ANKRD52	hsa-miR-4723-5p	82.9013	NM_173595
ANKRD52	hsa-miR-6870-5p	82.9013	NM_173595
ANKRD52	hsa-miR-5698	82.9013	NM_173595
ANKRD52	hsa-miR-4290	82.5231	NM_173595
ANKRD52	hsa-miR-4667-3p	82.3267	NM_173595
ANKRD52	hsa-miR-3175	81.9185	NM_173595
ANKRD52	hsa-miR-4726-3p	81.763	NM_173595
ANKRD52	hsa-miR-608	81.6714	NM_173595
ANKRD52	hsa-miR-6841-5p	81.5328	NM_173595
ANKRD52	hsa-miR-7162-3p	81.3175	NM_173595
ANKRD52	hsa-miR-4500	80.5658	NM_173595
ANKRD52	hsa-miR-1271-5p	80.3632	NM_173595
ANKRD52	hsa-miR-6887-3p	80.0242	NM_173595

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Motifs and transcription factors (TFs) regulating ANKRD52

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD52	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ANKRD52	transfac_pro__M04950	EGR1 (directAnnotation).
ANKRD52	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ANKRD52	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ANKRD52	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ANKRD52	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."