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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD44

Summary for ANKRD44

Gene information	Gene symbol	ANKRD44
	Ensembl ID	ENSG00000065413
	Entrez ID	91526
	Gene name	ankyrin repeat domain 44
	Synonyms	PP6-ARS-B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ANKRD44

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.296624	5.40e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.387268	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.420157	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.449946	3.19e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.357691	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.425377	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.347615	9.93e-16
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.451868	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.521772	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.443419	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.31662	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.280867	2.23e-14

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Expression of ANKRD44 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD44

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD44

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD44	hsa-miR-92b-3p	91.5411	NM_001195144
ANKRD44	hsa-miR-92a-3p	91.5411	NM_001195144
ANKRD44	hsa-miR-33b-5p	91.3599	NM_001195144
ANKRD44	hsa-miR-33a-5p	91.3599	NM_001195144
ANKRD44	hsa-miR-222-5p	91.2282	NM_001195144
ANKRD44	hsa-miR-133b	91.1529	NM_001195144
ANKRD44	hsa-miR-133a-3p	91.1529	NM_001195144
ANKRD44	hsa-miR-5196-5p	90.535	NM_153697
ANKRD44	hsa-miR-4747-5p	90.535	NM_153697
ANKRD44	hsa-miR-7152-5p	90.4815	NM_153697
ANKRD44	hsa-miR-4766-3p	90.4201	NM_001195144
ANKRD44	hsa-miR-8067	90.1729	NM_001195144
ANKRD44	hsa-miR-429	90.0668	NM_001195144
ANKRD44	hsa-miR-200c-3p	90.0668	NM_001195144
ANKRD44	hsa-miR-200b-3p	90.0668	NM_001195144
ANKRD44	hsa-miR-5691	90.0064	NM_001195144
ANKRD44	hsa-miR-6805-3p	90.0064	NM_001195144
ANKRD44	hsa-miR-367-3p	89.8433	NM_001195144
ANKRD44	hsa-miR-363-3p	89.8433	NM_001195144
ANKRD44	hsa-miR-25-3p	89.8433	NM_001195144
ANKRD44	hsa-miR-4420	89.7086	NM_001195144
ANKRD44	hsa-miR-181b-2-3p	89.7086	NM_001195144
ANKRD44	hsa-miR-181b-3p	89.7086	NM_001195144
ANKRD44	hsa-miR-7157-3p	89.4584	NM_001195144
ANKRD44	hsa-miR-6737-3p	89.4584	NM_001195144
ANKRD44	hsa-miR-5008-3p	89.4584	NM_001195144
ANKRD44	hsa-miR-4263	88.5211	NM_001195144
ANKRD44	hsa-miR-548aw	88.2114	NM_001195144
ANKRD44	hsa-miR-1244	87.7494	NM_001195144
ANKRD44	hsa-miR-3925-5p	86.7759	NM_001195144
ANKRD44	hsa-miR-1179	86.6728	NM_001195144
ANKRD44	hsa-miR-548l	86.6496	NM_001195144
ANKRD44	hsa-miR-6783-5p	86.4967	NM_001195144
ANKRD44	hsa-miR-218-5p	86.477	NM_001195144
ANKRD44	hsa-miR-4703-5p	86.309	NM_001195144
ANKRD44	hsa-miR-1252-5p	86.1062	NM_001195144
ANKRD44	hsa-miR-4782-3p	86.077	NM_001195144
ANKRD44	hsa-miR-9851-3p	85.8211	NM_001195144
ANKRD44	hsa-miR-587	85.6974	NM_001195144
ANKRD44	hsa-miR-605-5p	85.657	NM_001195144
ANKRD44	hsa-miR-369-3p	85.6246	NM_001195144
ANKRD44	hsa-miR-511-3p	85.2357	NM_001195144
ANKRD44	hsa-miR-190a-3p	85.1531	NM_001195144
ANKRD44	hsa-miR-506-3p	84.7886	NM_153697
ANKRD44	hsa-miR-124-3p	84.7886	NM_153697
ANKRD44	hsa-miR-153-5p	84.7876	NM_001195144
ANKRD44	hsa-miR-219a-5p	84.648	NM_001195144
ANKRD44	hsa-miR-6766-3p	84.648	NM_001195144
ANKRD44	hsa-miR-3942-5p	84.4124	NM_001195144
ANKRD44	hsa-miR-3908	84.4124	NM_001195144

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Motifs and transcription factors (TFs) regulating ANKRD44

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD44	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
ANKRD44	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
ANKRD44	transfac_pro__M05708	ZNF136 (directAnnotation).
ANKRD44	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
ANKRD44	transfac_pro__M06259	ZNF91 (directAnnotation).
ANKRD44	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ANKRD44	transfac_pro__M05380	NR2E1 (inferredBy_Orthology).
ANKRD44	hdpi__NRL	NRL (directAnnotation).
ANKRD44	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ANKRD44	cisbp__M00968	MTF2 (directAnnotation).
ANKRD44	hdpi__FEZF2	FEZF2 (directAnnotation).
ANKRD44	transfac_pro__M07310	SP5 (directAnnotation).
ANKRD44	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ANKRD44	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ANKRD44	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ANKRD44	metacluster_155.11	SPZ1 (directAnnotation).
ANKRD44	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ANKRD44	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ANKRD44	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ANKRD44	hdpi__HIP2	UBE2K (directAnnotation).
ANKRD44	hdpi__ZNF304	ZNF304 (directAnnotation).
ANKRD44	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
ANKRD44	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ANKRD44	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ANKRD44	transfac_pro__M02089	E2F3 (directAnnotation).
ANKRD44	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ANKRD44	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ANKRD44	cisbp__M07938	E2F1 (directAnnotation).
ANKRD44	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
ANKRD44	transfac_pro__M04817	ZBTB33 (directAnnotation).
ANKRD44	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ANKRD44	tfdimers__MD00483	ZBTB14 (directAnnotation).
ANKRD44	transfac_pro__M07317	CTBP1 (directAnnotation).
ANKRD44	transfac_pro__M12697	ZNF142 (directAnnotation).
ANKRD44	transfac_pro__M00716	ZBTB14 (directAnnotation).
ANKRD44	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ANKRD44	transfac_pro__M03806	ZBTB7C (directAnnotation).
ANKRD44	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ANKRD44	transfac_pro__M04893	TAF1 (directAnnotation).
ANKRD44	transfac_pro__M01253	CNOT3 (directAnnotation).
ANKRD44	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ANKRD44	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ANKRD44	transfac_pro__M01783	SP2 (directAnnotation).
ANKRD44	transfac_pro__M04916	TAF1 (directAnnotation).
ANKRD44	hdpi__RARA	RARA (directAnnotation).
ANKRD44	jaspar__MA1650.1	ZBTB14 (directAnnotation).
ANKRD44	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ANKRD44	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ANKRD44	cisbp__M08228	PAX5 (directAnnotation).
ANKRD44	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."