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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKIB1

Summary for ANKIB1

Gene information	Gene symbol	ANKIB1
	Ensembl ID	ENSG00000001629
	Entrez ID	54467
	Gene name	ankyrin repeat and IBR domain containing 1
	Synonyms	DKFZP434A0225\|KIAA1386
	Gene type	protein_coding
	UniProtAcc	Q9P2G1

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Dataset with differentially expressed gene: ANKIB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.325693	1.00e-14

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Expression of ANKIB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKIB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKIB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKIB1	hsa-miR-4438	89.8088	NM_019004
ANKIB1	hsa-miR-4735-5p	89.7942	NM_019004
ANKIB1	hsa-miR-664b-3p	89.7289	NM_019004
ANKIB1	hsa-miR-6882-5p	89.7039	NM_019004
ANKIB1	hsa-miR-142-5p	88.9009	NM_019004
ANKIB1	hsa-miR-548s	88.2107	NM_019004
ANKIB1	hsa-miR-10525-3p	87.9043	NM_019004
ANKIB1	hsa-miR-1269a	87.8251	NM_019004
ANKIB1	hsa-miR-1269b	87.8251	NM_019004
ANKIB1	hsa-miR-4697-3p	87.6855	NM_019004
ANKIB1	hsa-miR-548n	87.2874	NM_019004
ANKIB1	hsa-miR-1183	86.7664	NM_019004
ANKIB1	hsa-miR-12124	86.4771	NM_019004
ANKIB1	hsa-miR-579-3p	86.427	NM_019004
ANKIB1	hsa-miR-6716-5p	86.2834	NM_019004
ANKIB1	hsa-miR-186-3p	86.1157	NM_019004
ANKIB1	hsa-miR-548g-3p	86.0123	NM_019004
ANKIB1	hsa-miR-4761-5p	85.2675	NM_019004
ANKIB1	hsa-miR-1224-5p	85.1927	NM_019004
ANKIB1	hsa-miR-1293	84.547	NM_019004
ANKIB1	hsa-miR-3121-3p	84.4627	NM_019004
ANKIB1	hsa-miR-3145-3p	84.3582	NM_019004
ANKIB1	hsa-miR-5684	84.2798	NM_019004
ANKIB1	hsa-miR-495-3p	83.9096	NM_019004
ANKIB1	hsa-miR-5688	83.9096	NM_019004
ANKIB1	hsa-miR-571	83.7226	NM_019004
ANKIB1	hsa-miR-3184-3p	83.5424	NM_019004
ANKIB1	hsa-miR-182-5p	83.4268	NM_019004
ANKIB1	hsa-miR-6124	83.3379	NM_019004
ANKIB1	hsa-miR-3922-5p	83.2552	NM_019004
ANKIB1	hsa-miR-3680-5p	82.9236	NM_019004
ANKIB1	hsa-miR-8059	82.7309	NM_019004
ANKIB1	hsa-miR-4471	82.7309	NM_019004
ANKIB1	hsa-miR-92b-3p	82.5719	NM_019004
ANKIB1	hsa-miR-363-3p	82.5719	NM_019004
ANKIB1	hsa-miR-32-5p	82.5719	NM_019004
ANKIB1	hsa-miR-367-3p	82.5719	NM_019004
ANKIB1	hsa-miR-25-3p	82.5719	NM_019004
ANKIB1	hsa-miR-92a-3p	82.5719	NM_019004
ANKIB1	hsa-miR-4766-3p	82.5674	NM_019004
ANKIB1	hsa-miR-670-5p	82.4376	NM_019004
ANKIB1	hsa-miR-2681-5p	82.0371	NM_019004
ANKIB1	hsa-miR-4483	81.8885	NM_019004
ANKIB1	hsa-miR-3146	81.2428	NM_019004
ANKIB1	hsa-miR-224-5p	81.2321	NM_019004
ANKIB1	hsa-miR-4800-5p	80.8623	NM_019004
ANKIB1	hsa-miR-601	80.5491	NM_019004
ANKIB1	hsa-miR-6750-5p	80.529	NM_019004
ANKIB1	hsa-miR-6822-5p	80.529	NM_019004
ANKIB1	hsa-miR-570-3p	80.4558	NM_019004

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Motifs and transcription factors (TFs) regulating ANKIB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKIB1	jaspar__MA0079.5	SP1 (directAnnotation).
ANKIB1	transfac_pro__M01253	CNOT3 (directAnnotation).
ANKIB1	transfac_pro__M04817	ZBTB33 (directAnnotation).
ANKIB1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ANKIB1	transfac_pro__M05712	ZNF134 (directAnnotation).
ANKIB1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."