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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AHR

Summary for AHR

Gene information	Gene symbol	AHR
	Ensembl ID	ENSG00000106546
	Entrez ID	196
	Gene name	aryl hydrocarbon receptor
	Synonyms	bHLHe76
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AHR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.447135	5.86e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.284939	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.310621	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.269743	7.37e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.5869	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.763127	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.518284	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.03427	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.456232	0.00e+00

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Expression of AHR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AHR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AHR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AHR	hsa-miR-3190-3p	88.5837	NM_001621
AHR	hsa-miR-6508-5p	87.8919	NM_001621
AHR	hsa-miR-12136	87.8413	NM_001621
AHR	hsa-miR-32-3p	86.8623	NM_001621
AHR	hsa-miR-4735-5p	86.7248	NM_001621
AHR	hsa-miR-338-5p	86.654	NM_001621
AHR	hsa-miR-6083	86.4677	NM_001621
AHR	hsa-miR-302e	86.424	NM_001621
AHR	hsa-miR-10527-5p	86.2516	NM_001621
AHR	hsa-miR-605-5p	85.9011	NM_001621
AHR	hsa-miR-1185-5p	85.8454	NM_001621
AHR	hsa-miR-548c-3p	85.7605	NM_001621
AHR	hsa-miR-4503	85.4855	NM_001621
AHR	hsa-miR-548p	85.4301	NM_001621
AHR	hsa-miR-8067	85.2234	NM_001621
AHR	hsa-miR-203a-3p	85.1019	NM_001621
AHR	hsa-miR-200b-5p	85.0539	NM_001621
AHR	hsa-miR-200a-5p	85.0539	NM_001621
AHR	hsa-miR-590-3p	84.7314	NM_001621
AHR	hsa-miR-6792-5p	84.6562	NM_001621
AHR	hsa-miR-3161	84.3902	NM_001621
AHR	hsa-miR-3671	84.3241	NM_001621
AHR	hsa-miR-3910	83.9971	NM_001621
AHR	hsa-miR-3714	83.9971	NM_001621
AHR	hsa-miR-96-5p	83.7098	NM_001621
AHR	hsa-miR-147b-5p	83.4722	NM_001621
AHR	hsa-miR-1271-5p	83.2675	NM_001621
AHR	hsa-miR-12133	83.2675	NM_001621
AHR	hsa-miR-3136-5p	83.2139	NM_001621
AHR	hsa-miR-4439	83.2139	NM_001621
AHR	hsa-miR-767-5p	82.8642	NM_001621
AHR	hsa-miR-561-3p	82.431	NM_001621
AHR	hsa-miR-1-5p	82.3132	NM_001621
AHR	hsa-miR-4496	81.7493	NM_001621
AHR	hsa-miR-670-5p	81.152	NM_001621
AHR	hsa-miR-3659	80.7009	NM_001621
AHR	hsa-miR-7161-5p	80.3811	NM_001621
AHR	hsa-miR-548u	80.3495	NM_001621
AHR	hsa-miR-542-3p	80.2239	NM_001621

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Motifs and transcription factors (TFs) regulating AHR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AHR	transfac_pro__M06213	ZNF267 (directAnnotation).
AHR	transfac_pro__M01861	ATF1 (directAnnotation).
AHR	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
AHR	jaspar__MA1596.1	ZNF460 (directAnnotation).
AHR	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
AHR	metacluster_35.7	HINFP (inferredBy_Orthology).
AHR	metacluster_98.1	ZNF524 (directAnnotation).
AHR	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
AHR	metacluster_135.11	NR2C2 (directAnnotation).
AHR	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AHR	tfdimers__MD00038	TFAP2C (directAnnotation).
AHR	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
AHR	metacluster_7.13	ZFX (directAnnotation).
AHR	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AHR	cisbp__M00968	MTF2 (directAnnotation).
AHR	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AHR	metacluster_160.20	JUND; PRDM15 (directAnnotation).
AHR	cisbp__M00341	PAX6 (directAnnotation).
AHR	metacluster_198.3	ZFP64 (directAnnotation).
AHR	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AHR	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
AHR	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
AHR	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
AHR	cisbp__M00788	ZFY (inferredBy_Orthology).
AHR	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
AHR	metacluster_175.1	ZNF283 (directAnnotation).
AHR	hdpi__ZNF304	ZNF304 (directAnnotation).
AHR	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
AHR	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
AHR	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
AHR	transfac_pro__M01199	TRIM28 (directAnnotation).
AHR	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
AHR	metacluster_151.2	ZNF23 (directAnnotation).
AHR	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
AHR	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
AHR	transfac_pro__M03806	ZBTB7C (directAnnotation).
AHR	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
AHR	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
AHR	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
AHR	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
AHR	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
AHR	jaspar__MA1721.1	ZNF93 (directAnnotation).
AHR	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
AHR	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
AHR	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
AHR	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
AHR	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
AHR	transfac_pro__M01253	CNOT3 (directAnnotation).
AHR	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
AHR	transfac_pro__M02913	SP140 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AHR	"1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine"	DB08624	small molecule
AHR	"Atorvastatin"	DB01076	small molecule
AHR	"beta-Naphthoflavone"	DB06732	small molecule
AHR	"Cantharidin"	DB12328	small molecule
AHR	"Carbendazim"	DB13009	small molecule
AHR	"Diosmin"	DB08995	small molecule
AHR	"Emodin"	DB07715	small molecule
AHR	"Epigallocatechin gallate"	DB12116	small molecule
AHR	"Flutamide"	DB00499	small molecule
AHR	"Ginseng"	DB01404	biotech
AHR	"Indigo"	DB16862	small molecule
AHR	"Indirubin"	DB12379	small molecule
AHR	"Indirubin-3'-monoxime"	DB02052	small molecule
AHR	"Kynurenic Acid"	DB11937	small molecule
AHR	"Leflunomide"	DB01097	small molecule
AHR	"Mexiletine"	DB00379	small molecule
AHR	"Nimodipine"	DB00393	small molecule
AHR	"Omeprazole"	DB00338	small molecule
AHR	"Quercetin"	DB04216	small molecule
AHR	"Resveratrol"	DB02709	small molecule
AHR	"Tapinarof"	DB06083	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."