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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AGFG1

Summary for AGFG1

Gene information	Gene symbol	AGFG1
	Ensembl ID	ENSG00000173744
	Entrez ID	3267
	Gene name	ArfGAP with FG repeats 1
	Synonyms	HRB\|RAB\|RIP
	Gene type	protein_coding
	UniProtAcc	P52594

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Dataset with differentially expressed gene: AGFG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.318615	9.58e-25
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.286286	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.767351	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.371063	1.89e-25

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Expression of AGFG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AGFG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AGFG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AGFG1	hsa-miR-4801	90.8977	NM_001135187
AGFG1	hsa-miR-450b-5p	90.7849	NM_001135187
AGFG1	hsa-miR-3680-3p	90.7849	NM_001135187
AGFG1	hsa-miR-7161-5p	90.1568	NM_001135187
AGFG1	hsa-miR-4775	90.1136	NM_001135187
AGFG1	hsa-miR-20b-5p	90.0849	NM_001135187
AGFG1	hsa-miR-93-5p	90.0849	NM_001135187
AGFG1	hsa-miR-17-5p	90.0849	NM_001135187
AGFG1	hsa-miR-526b-3p	90.0849	NM_001135187
AGFG1	hsa-miR-106a-5p	90.0849	NM_001135187
AGFG1	hsa-miR-519d-3p	90.0849	NM_001135187
AGFG1	hsa-miR-5571-3p	90.0822	NM_001135187
AGFG1	hsa-miR-145-5p	89.9949	NM_001135187
AGFG1	hsa-miR-5195-3p	89.9949	NM_001135187
AGFG1	hsa-miR-7-1-3p	89.7942	NM_001135187
AGFG1	hsa-miR-7-2-3p	89.7942	NM_001135187
AGFG1	hsa-miR-3662	89.6134	NM_001135187
AGFG1	hsa-miR-4731-3p	89.4397	NM_001135187
AGFG1	hsa-miR-320c	88.7012	NM_001135187
AGFG1	hsa-miR-320a-3p	88.7012	NM_001135187
AGFG1	hsa-miR-320d	88.7012	NM_001135187
AGFG1	hsa-miR-4429	88.7012	NM_001135187
AGFG1	hsa-miR-320b	88.7012	NM_001135187
AGFG1	hsa-miR-200c-3p	88.6346	NM_001135187
AGFG1	hsa-miR-429	88.6346	NM_001135187
AGFG1	hsa-miR-200b-3p	88.6346	NM_001135187
AGFG1	hsa-miR-6811-5p	88.4524	NM_001135187
AGFG1	hsa-miR-6511b-5p	88.4524	NM_001135187
AGFG1	hsa-miR-3658	88.4502	NM_001135187
AGFG1	hsa-miR-548p	88.1931	NM_001135187
AGFG1	hsa-miR-2114-3p	88.177	NM_001135187
AGFG1	hsa-miR-4796-3p	88.1372	NM_001135187
AGFG1	hsa-miR-520d-5p	88.1125	NM_001135187
AGFG1	hsa-miR-524-5p	88.1125	NM_001135187
AGFG1	hsa-miR-3121-3p	87.9595	NM_001135187
AGFG1	hsa-miR-2355-5p	87.8705	NM_001135187
AGFG1	hsa-miR-548an	87.8062	NM_001135187
AGFG1	hsa-miR-4753-5p	87.7426	NM_001135187
AGFG1	hsa-miR-1184	87.7006	NM_001135187
AGFG1	hsa-miR-548n	87.5754	NM_001135187
AGFG1	hsa-miR-1298-5p	87.4974	NM_001135187
AGFG1	hsa-miR-6823-3p	87.1086	NM_001135187
AGFG1	hsa-miR-12122	86.898	NM_001135187
AGFG1	hsa-miR-548l	86.5873	NM_001135187
AGFG1	hsa-miR-300	86.5514	NM_001135187
AGFG1	hsa-miR-381-3p	86.5514	NM_001135187
AGFG1	hsa-miR-3148	86.5443	NM_001135187
AGFG1	hsa-miR-4262	86.344	NM_001135187
AGFG1	hsa-miR-4803	86.0074	NM_001135187
AGFG1	hsa-miR-4717-5p	85.9783	NM_001135187

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Motifs and transcription factors (TFs) regulating AGFG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AGFG1	transfac_pro__M00652	NRF1 (directAnnotation).
AGFG1	transfac_pro__M01298	MECP2 (directAnnotation).
AGFG1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
AGFG1	metacluster_7.13	ZFX (directAnnotation).
AGFG1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
AGFG1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
AGFG1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AGFG1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
AGFG1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AGFG1	cisbp__M00249	WT1 (directAnnotation).
AGFG1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
AGFG1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
AGFG1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
AGFG1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
AGFG1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
AGFG1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
AGFG1	transfac_pro__M05432	ZSCAN18 (directAnnotation).
AGFG1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
AGFG1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AGFG1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
AGFG1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
AGFG1	jaspar__MA1721.1	ZNF93 (directAnnotation).
AGFG1	metacluster_151.2	ZNF23 (directAnnotation).
AGFG1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
AGFG1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
AGFG1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
AGFG1	transfac_pro__M01199	TRIM28 (directAnnotation).
AGFG1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
AGFG1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
AGFG1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
AGFG1	transfac_pro__M01253	CNOT3 (directAnnotation).
AGFG1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
AGFG1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
AGFG1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
AGFG1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
AGFG1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
AGFG1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
AGFG1	cisbp__M00968	MTF2 (directAnnotation).
AGFG1	jaspar__MA0748.2	YY2 (directAnnotation).
AGFG1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
AGFG1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
AGFG1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
AGFG1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
AGFG1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
AGFG1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
AGFG1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
AGFG1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
AGFG1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AGFG1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
AGFG1	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."