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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AFF4

Summary for AFF4

Gene information	Gene symbol	AFF4
	Ensembl ID	ENSG00000072364
	Entrez ID	27125
	Gene name	ALF transcription elongation factor 4
	Synonyms	AF5Q31\|MCEF
	Gene type	protein_coding
	UniProtAcc	Q9UHB7

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Dataset with differentially expressed gene: AFF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.272523	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.290452	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.267124	5.69e-06
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.277734	4.04e-06
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.929145	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.308238	1.28e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.489158	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.376508	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.345875	2.78e-19
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.302417	4.66e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.283259	6.20e-42
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.399578	1.31e-25

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Expression of AFF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AFF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AFF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AFF4	hsa-miR-6516-3p	92.6968	NM_014423
AFF4	hsa-miR-4676-3p	92.5329	NM_014423
AFF4	hsa-miR-892c-3p	92.5329	NM_014423
AFF4	hsa-miR-452-5p	92.5329	NM_014423
AFF4	hsa-miR-6851-3p	92.4912	NM_014423
AFF4	hsa-miR-1178-3p	92.3799	NM_014423
AFF4	hsa-miR-5590-5p	91.7951	NM_014423
AFF4	hsa-miR-6809-5p	91.5852	NM_014423
AFF4	hsa-miR-1256	91.5224	NM_014423
AFF4	hsa-miR-208b-5p	91.5078	NM_014423
AFF4	hsa-miR-208a-5p	91.3904	NM_014423
AFF4	hsa-miR-1261	90.8736	NM_014423
AFF4	hsa-miR-4657	90.8258	NM_014423
AFF4	hsa-miR-4491	90.8258	NM_014423
AFF4	hsa-miR-4282	90.6519	NM_014423
AFF4	hsa-miR-586	90.5663	NM_014423
AFF4	hsa-miR-335-3p	90.4919	NM_014423
AFF4	hsa-miR-4775	90.4539	NM_014423
AFF4	hsa-miR-548e-5p	90.3253	NM_014423
AFF4	hsa-miR-590-3p	90.0757	NM_014423
AFF4	hsa-miR-6847-5p	89.8754	NM_014423
AFF4	hsa-miR-548au-3p	89.2347	NM_014423
AFF4	hsa-miR-190a-3p	89.1616	NM_014423
AFF4	hsa-miR-655-3p	88.7678	NM_014423
AFF4	hsa-miR-374c-5p	88.7678	NM_014423
AFF4	hsa-miR-1277-5p	88.7223	NM_014423
AFF4	hsa-miR-204-3p	88.5127	NM_014423
AFF4	hsa-miR-4646-5p	88.5127	NM_014423
AFF4	hsa-miR-5007-5p	88.4442	NM_014423
AFF4	hsa-miR-664a-3p	88.3063	NM_014423
AFF4	hsa-miR-4688	88.2942	NM_014423
AFF4	hsa-miR-4776-3p	88.1633	NM_014423
AFF4	hsa-miR-8084	88.0393	NM_014423
AFF4	hsa-miR-6882-3p	87.9012	NM_014423
AFF4	hsa-miR-6124	87.8316	NM_014423
AFF4	hsa-miR-4257	87.7702	NM_014423
AFF4	hsa-miR-3156-5p	87.4654	NM_014423
AFF4	hsa-miR-3529-3p	87.4206	NM_014423
AFF4	hsa-miR-5680	87.2743	NM_014423
AFF4	hsa-miR-4424	86.6425	NM_014423
AFF4	hsa-miR-5580-3p	86.5889	NM_014423
AFF4	hsa-miR-300	86.276	NM_014423
AFF4	hsa-miR-381-3p	86.276	NM_014423
AFF4	hsa-miR-4795-3p	86.2478	NM_014423
AFF4	hsa-miR-140-3p	86.2436	NM_014423
AFF4	hsa-miR-3714	86.2304	NM_014423
AFF4	hsa-miR-6511a-5p	86.1449	NM_014423
AFF4	hsa-miR-1910-3p	86.1449	NM_014423
AFF4	hsa-miR-627-3p	86.0583	NM_014423
AFF4	hsa-miR-4314	86.0003	NM_014423

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Motifs and transcription factors (TFs) regulating AFF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AFF4	metacluster_7.13	ZFX (directAnnotation).
AFF4	cisbp__M01863	ZNF711 (inferredBy_Orthology).
AFF4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
AFF4	metacluster_151.2	ZNF23 (directAnnotation).
AFF4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
AFF4	transfac_pro__M05479	ZNF580 (directAnnotation).
AFF4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AFF4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
AFF4	metacluster_182.10	ZFX (directAnnotation).
AFF4	hdpi__ETV4	ETV4 (directAnnotation).
AFF4	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
AFF4	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
AFF4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AFF4	jaspar__MA0079.5	SP1 (directAnnotation).
AFF4	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
AFF4	transfac_pro__M04826	EP300 (directAnnotation).
AFF4	metacluster_3.10	KLF2; KLF4 (directAnnotation).
AFF4	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
AFF4	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
AFF4	transfac_pro__M01783	SP2 (directAnnotation).
AFF4	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
AFF4	cisbp__M00341	PAX6 (directAnnotation).
AFF4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AFF4	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
AFF4	transfac_pro__M01253	CNOT3 (directAnnotation).
AFF4	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
AFF4	cisbp__M00968	MTF2 (directAnnotation).
AFF4	transfac_pro__M04817	ZBTB33 (directAnnotation).
AFF4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
AFF4	transfac_pro__M02089	E2F3 (directAnnotation).
AFF4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
AFF4	jaspar__MA0748.2	YY2 (directAnnotation).
AFF4	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
AFF4	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
AFF4	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
AFF4	metacluster_135.11	NR2C2 (directAnnotation).
AFF4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
AFF4	metacluster_198.3	ZFP64 (directAnnotation).
AFF4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AFF4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
AFF4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
AFF4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
AFF4	cisbp__M00788	ZFY (inferredBy_Orthology).
AFF4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
AFF4	metacluster_175.1	ZNF283 (directAnnotation).
AFF4	hdpi__ZNF304	ZNF304 (directAnnotation).
AFF4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
AFF4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
AFF4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
AFF4	transfac_pro__M01199	TRIM28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."