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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AEBP2

Summary for AEBP2

Gene information	Gene symbol	AEBP2
	Ensembl ID	ENSG00000139154
	Entrez ID	121536
	Gene name	AE binding protein 2
	Synonyms	MGC17922
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AEBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.276283	9.25e-17

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Expression of AEBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AEBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AEBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AEBP2	hsa-miR-548f-5p	90.4072	NM_153207
AEBP2	hsa-miR-34c-3p	90.213	NM_153207
AEBP2	hsa-miR-1305	90.1492	NM_153207
AEBP2	hsa-miR-3115	89.9778	NM_001114176
AEBP2	hsa-miR-371b-5p	89.6488	NM_001114176
AEBP2	hsa-miR-373-5p	89.6488	NM_001114176
AEBP2	hsa-miR-616-5p	89.6488	NM_001114176
AEBP2	hsa-miR-653-3p	89.6047	NM_153207
AEBP2	hsa-miR-127-5p	89.5544	NM_153207
AEBP2	hsa-miR-4697-3p	89.3063	NM_153207
AEBP2	hsa-miR-183-3p	89.0546	NM_001114176
AEBP2	hsa-miR-8070	88.9824	NM_001114176
AEBP2	hsa-miR-190a-3p	88.8806	NM_001114176
AEBP2	hsa-miR-335-3p	88.5841	NM_153207
AEBP2	hsa-miR-4729	88.5518	NM_001114176
AEBP2	hsa-miR-144-3p	88.5237	NM_153207
AEBP2	hsa-miR-4720-3p	88.1076	NM_153207
AEBP2	hsa-miR-1243	87.9956	NM_153207
AEBP2	hsa-miR-181b-2-3p	87.9878	NM_153207
AEBP2	hsa-miR-181b-3p	87.9878	NM_153207
AEBP2	hsa-miR-4420	87.9878	NM_153207
AEBP2	hsa-miR-6838-3p	87.9696	NM_001114176
AEBP2	hsa-miR-548c-3p	87.9154	NM_001114176
AEBP2	hsa-miR-374c-5p	87.7866	NM_001114176
AEBP2	hsa-miR-655-3p	87.7866	NM_001114176
AEBP2	hsa-miR-4436b-5p	87.1314	NM_001114176
AEBP2	hsa-miR-511-3p	86.7085	NM_001114176
AEBP2	hsa-miR-4432	86.5513	NM_153207
AEBP2	hsa-miR-5009-3p	86.5379	NM_153207
AEBP2	hsa-miR-5190	86.4963	NM_153207
AEBP2	hsa-miR-4778-5p	86.4479	NM_001114176
AEBP2	hsa-miR-1299	86.3053	NM_001114176
AEBP2	hsa-miR-139-5p	86.2951	NM_153207
AEBP2	hsa-miR-544a	86.1651	NM_153207
AEBP2	hsa-miR-3180-5p	86.0735	NM_153207
AEBP2	hsa-miR-518a-5p	86.0712	NM_153207
AEBP2	hsa-miR-527	86.0712	NM_153207
AEBP2	hsa-miR-199b-3p	86.0641	NM_153207
AEBP2	hsa-miR-3129-5p	86.0641	NM_153207
AEBP2	hsa-miR-199a-3p	86.0641	NM_153207
AEBP2	hsa-miR-6730-5p	86.0255	NM_153207
AEBP2	hsa-miR-4699-5p	85.8368	NM_001114176
AEBP2	hsa-miR-1208	85.4617	NM_153207
AEBP2	hsa-miR-466	85.182	NM_001114176
AEBP2	hsa-miR-6739-3p	85.1653	NM_001114176
AEBP2	hsa-miR-670-3p	84.7436	NM_001114176
AEBP2	hsa-miR-1909-5p	84.7376	NM_153207
AEBP2	hsa-miR-96-5p	84.5269	NM_153207
AEBP2	hsa-miR-122b-5p	83.8945	NM_001114176
AEBP2	hsa-miR-656-3p	83.7287	NM_153207

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Motifs and transcription factors (TFs) regulating AEBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AEBP2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."