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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADD3

Summary for ADD3

Gene information	Gene symbol	ADD3
	Ensembl ID	ENSG00000148700
	Entrez ID	120
	Gene name	adducin 3
	Synonyms	ADDL
	Gene type	protein_coding
	UniProtAcc	Q9UEY8

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Dataset with differentially expressed gene: ADD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.2872	3.14e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.28432	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.353531	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.356919	2.28e-06
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.260655	2.84e-37
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.383322	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.813616	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.297458	1.03e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.258574	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.462462	0.00e+00

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Expression of ADD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADD3	hsa-miR-1301-5p	86.6408	NM_001121
ADD3	hsa-miR-5696	86.1802	NM_001121
ADD3	hsa-miR-576-3p	85.9456	NM_001121
ADD3	hsa-miR-4517	85.7316	NM_019903
ADD3	hsa-miR-653-5p	85.4936	NM_019903
ADD3	hsa-miR-1244	85.3625	NM_001121
ADD3	hsa-miR-8070	85.169	NM_019903
ADD3	hsa-miR-199a-5p	85.0692	NM_001121
ADD3	hsa-miR-199b-5p	85.0692	NM_001121
ADD3	hsa-miR-302f	84.4805	NM_019903
ADD3	hsa-miR-4766-5p	84.3922	NM_019903
ADD3	hsa-miR-323a-3p	84.3505	NM_001121
ADD3	hsa-miR-199a-3p	84.3413	NM_001121
ADD3	hsa-miR-199b-3p	84.3413	NM_001121
ADD3	hsa-miR-3149	83.6947	NM_001121
ADD3	hsa-miR-3180-5p	83.6243	NM_001121
ADD3	hsa-miR-4699-3p	83.5682	NM_001121
ADD3	hsa-miR-96-5p	83.1309	NM_001121
ADD3	hsa-miR-448	82.8529	NM_019903
ADD3	hsa-miR-3671	82.8044	NM_001121
ADD3	hsa-miR-374c-5p	82.5142	NM_001121
ADD3	hsa-miR-655-3p	82.5142	NM_001121
ADD3	hsa-miR-4795-5p	82.2108	NM_001121
ADD3	hsa-miR-5706	82.1168	NM_019903
ADD3	hsa-miR-4782-5p	82.1168	NM_019903
ADD3	hsa-miR-1271-5p	81.9176	NM_001121
ADD3	hsa-miR-12136	81.8496	NM_019903
ADD3	hsa-miR-605-5p	81.8198	NM_001121
ADD3	hsa-miR-1197	81.791	NM_019903
ADD3	hsa-miR-6507-3p	81.6703	NM_019903
ADD3	hsa-miR-6758-3p	81.6018	NM_001121
ADD3	hsa-miR-921	81.1083	NM_019903
ADD3	hsa-miR-1324	81.0695	NM_019903
ADD3	hsa-miR-3662	80.5819	NM_019903
ADD3	hsa-miR-3177-5p	80.3947	NM_019903
ADD3	hsa-miR-539-5p	80.3276	NM_019903

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Motifs and transcription factors (TFs) regulating ADD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADD3	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ADD3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ADD3	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
ADD3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ADD3	transfac_pro__M04617	ZBTB7A (directAnnotation).
ADD3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ADD3	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ADD3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ADD3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ADD3	transfac_pro__M07387	ZBTB7A (directAnnotation).
ADD3	transfac_pro__M07436	WT1 (directAnnotation).
ADD3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ADD3	transfac_pro__M00716	ZBTB14 (directAnnotation).
ADD3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ADD3	hdpi__HIP2	UBE2K (directAnnotation).
ADD3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ADD3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ADD3	transfac_pro__M04893	TAF1 (directAnnotation).
ADD3	transfac_pro__M03876	ZBTB33 (directAnnotation).
ADD3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ADD3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ADD3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ADD3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ADD3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ADD3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ADD3	transfac_pro__M06260	ZNF91 (directAnnotation).
ADD3	transfac_pro__M06721	ZKSCAN7 (directAnnotation).
ADD3	transfac_pro__M05392	SCRT2 (inferredBy_Orthology).
ADD3	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
ADD3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ADD3	transfac_pro__M06763	ZNF225 (directAnnotation).
ADD3	dbtfbs__WT1_HEK293_ENCSR966PJJ_merged_N1	WT1 (directAnnotation).
ADD3	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
ADD3	jaspar__MA1946.1	FOXI1 (directAnnotation).
ADD3	transfac_pro__M06102	ZNF16 (directAnnotation).
ADD3	transfac_pro__M06506	ZFP62 (directAnnotation).
ADD3	metacluster_168.11	ZNF771; ZNF771 (directAnnotation).
ADD3	transfac_pro__M05981	ZNF233 (directAnnotation).
ADD3	jaspar__MA0502.2	NFYB (directAnnotation).
ADD3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ADD3	transfac_pro__M04950	EGR1 (directAnnotation).
ADD3	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
ADD3	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
ADD3	transfac_pro__M05427	ZNF516 (directAnnotation).
ADD3	metacluster_172.6	CHD2; E2F1 (directAnnotation).
ADD3	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
ADD3	transfac_pro__M06071	ZNF814 (directAnnotation).
ADD3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ADD3	hdpi__NRL	NRL (directAnnotation).
ADD3	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."