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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADAM12

Summary for ADAM12

Gene information	Gene symbol	ADAM12
	Ensembl ID	ENSG00000148848
	Entrez ID	8038
	Gene name	ADAM metallopeptidase domain 12
	Synonyms	MCMPMltna\|MLTN
	Gene type	protein_coding
	UniProtAcc	O43184

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Dataset with differentially expressed gene: ADAM12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.23517	1.68e-11
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.333792	1.71e-13

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Expression of ADAM12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADAM12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADAM12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADAM12	hsa-miR-30e-5p	83.7937	NM_001288973
ADAM12	hsa-miR-6839-3p	83.4877	NM_001288973
ADAM12	hsa-miR-599	83.4818	NM_001288973
ADAM12	hsa-miR-892c-5p	83.4419	NM_001288973
ADAM12	hsa-miR-8082	83.0265	NM_001288975
ADAM12	hsa-miR-6124	83.0019	NM_001288973
ADAM12	hsa-miR-4694-3p	82.9195	NM_001288973
ADAM12	hsa-miR-6832-5p	82.72	NM_001288973
ADAM12	hsa-miR-5010-3p	82.1439	NM_001288973
ADAM12	hsa-miR-4743-3p	81.8066	NM_001288973
ADAM12	hsa-miR-378g	81.769	NM_001288973
ADAM12	hsa-miR-301b-3p	81.7362	NM_001288973
ADAM12	hsa-miR-130b-3p	81.7362	NM_001288973
ADAM12	hsa-miR-301a-3p	81.7362	NM_001288973
ADAM12	hsa-miR-130a-3p	81.7362	NM_001288973
ADAM12	hsa-miR-4295	81.7362	NM_001288973
ADAM12	hsa-miR-3666	81.7362	NM_001288973
ADAM12	hsa-miR-30c-5p	81.611	NM_001288973
ADAM12	hsa-miR-30b-5p	81.611	NM_001288973
ADAM12	hsa-miR-30d-5p	81.611	NM_001288973
ADAM12	hsa-miR-30a-5p	81.611	NM_001288973
ADAM12	hsa-miR-539-5p	81.0863	NM_001288973
ADAM12	hsa-miR-10394-5p	80.851	NM_001288975
ADAM12	hsa-miR-6797-5p	80.7466	NM_001288973
ADAM12	hsa-miR-1249-5p	80.7466	NM_001288973
ADAM12	hsa-miR-4534	80.3376	NM_001288975
ADAM12	hsa-miR-4516	80.3238	NM_001288973
ADAM12	hsa-miR-335-3p	80.2861	NM_001288975
ADAM12	hsa-miR-23c	80.0614	NM_001288973
ADAM12	hsa-miR-432-3p	80.0163	NM_001288975

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Motifs and transcription factors (TFs) regulating ADAM12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADAM12	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ADAM12	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ADAM12	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ADAM12	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ADAM12	transfac_pro__M07387	ZBTB7A (directAnnotation).
ADAM12	transfac_pro__M07436	WT1 (directAnnotation).
ADAM12	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ADAM12	hdpi__HIP2	UBE2K (directAnnotation).
ADAM12	transfac_pro__M03876	ZBTB33 (directAnnotation).
ADAM12	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ADAM12	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ADAM12	metacluster_134.3	FOXA1; FOXA1; FOXC1; FOXG1; FOXG1; FOXI1; FOXJ3; FOXJ3; FOXJ3; FOXK2; FOXL2; FOXO1; FOXO1; FOXO1; FOXO3; FOXO3; FOXO4; FOXO4; FOXO4; FOXP1; FOXP1; FOXP2; FOXP2; FOXP2 (directAnnotation). FOXD1; FOXJ2; FOXJ2; FOXJ3; FOXK1; FOXL2; FOXL2; FOXL2; FOXO1; FOXO3; FOXO3; FOXP2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."