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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ACSL4

Summary for ACSL4

Gene information	Gene symbol	ACSL4
	Ensembl ID	ENSG00000068366
	Entrez ID	2182
	Gene name	acyl-CoA synthetase long chain family member 4
	Synonyms	ACS4\|FACL4\|LACS4\|MRX63\|MRX68
	Gene type	protein_coding
	UniProtAcc	O60488

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Dataset with differentially expressed gene: ACSL4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.366048	6.80e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.3697	2.25e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.327554	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.27175	4.69e-12
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.256333	1.42e-06
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.255752	3.63e-07

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Expression of ACSL4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACSL4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACSL4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACSL4	hsa-miR-3200-5p	88.0657	NM_022977
ACSL4	hsa-miR-5684	87.9012	NM_022977
ACSL4	hsa-miR-6876-5p	87.8626	NM_001318509
ACSL4	hsa-miR-6869-5p	87.8585	NM_001318509
ACSL4	hsa-miR-6820-3p	87.7342	NM_001318509
ACSL4	hsa-miR-3164	87.7342	NM_001318509
ACSL4	hsa-miR-4524a-5p	87.6342	NM_001318509
ACSL4	hsa-miR-6124	87.5877	NM_001318509
ACSL4	hsa-miR-34a-5p	87.3124	NM_001318509
ACSL4	hsa-miR-6513-3p	86.9965	NM_022977
ACSL4	hsa-miR-181d-5p	86.7733	NM_001318509
ACSL4	hsa-miR-181a-5p	86.7733	NM_001318509
ACSL4	hsa-miR-181b-5p	86.7733	NM_001318509
ACSL4	hsa-miR-181c-5p	86.7733	NM_001318509
ACSL4	hsa-miR-142-3p	86.373	NM_001318509
ACSL4	hsa-miR-450b-5p	86.207	NM_022977
ACSL4	hsa-miR-3662	86.1936	NM_022977
ACSL4	hsa-miR-4255	85.9817	NM_001318509
ACSL4	hsa-miR-34c-5p	85.7278	NM_001318509
ACSL4	hsa-miR-520g-5p	85.6259	NM_022977
ACSL4	hsa-miR-623	85.1926	NM_022977
ACSL4	hsa-miR-5004-3p	85.1763	NM_001318509
ACSL4	hsa-miR-5010-3p	84.7366	NM_022977
ACSL4	hsa-miR-342-3p	84.6485	NM_022977
ACSL4	hsa-miR-4668-5p	83.9546	NM_022977
ACSL4	hsa-miR-144-3p	83.8191	NM_001318509
ACSL4	hsa-miR-449a	83.6383	NM_001318509
ACSL4	hsa-miR-4524b-5p	83.3753	NM_001318509
ACSL4	hsa-miR-548c-3p	83.122	NM_001318509
ACSL4	hsa-miR-4263	82.5327	NM_001318509
ACSL4	hsa-miR-15a-5p	82.3589	NM_001318509
ACSL4	hsa-miR-15b-5p	82.3589	NM_001318509
ACSL4	hsa-miR-16-5p	82.3589	NM_001318509
ACSL4	hsa-miR-195-5p	82.3589	NM_001318509
ACSL4	hsa-miR-944	82.2979	NM_001318509
ACSL4	hsa-miR-342-5p	81.9077	NM_001318509
ACSL4	hsa-miR-889-5p	81.822	NM_001318509
ACSL4	hsa-miR-3163	81.6598	NM_001318509
ACSL4	hsa-miR-208a-5p	81.6304	NM_022977
ACSL4	hsa-miR-208b-5p	81.6304	NM_022977
ACSL4	hsa-miR-12128	81.5907	NM_022977
ACSL4	hsa-miR-520d-5p	81.4726	NM_001318509
ACSL4	hsa-miR-524-5p	81.4726	NM_001318509
ACSL4	hsa-miR-449b-5p	81.4721	NM_001318509
ACSL4	hsa-miR-548k	80.7525	NM_022977
ACSL4	hsa-miR-548av-5p	80.7525	NM_022977
ACSL4	hsa-miR-5680	80.7217	NM_001318509
ACSL4	hsa-miR-4422	80.6551	NM_001318509
ACSL4	hsa-miR-6835-3p	80.6551	NM_001318509
ACSL4	hsa-miR-150-5p	80.5897	NM_022977

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Motifs and transcription factors (TFs) regulating ACSL4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACSL4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ACSL4	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ACSL4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ACSL4	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ACSL4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ACSL4	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ACSL4	jaspar__MA1721.1	ZNF93 (directAnnotation).
ACSL4	metacluster_151.2	ZNF23 (directAnnotation).
ACSL4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ACSL4	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ACSL4	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ACSL4	transfac_pro__M01199	TRIM28 (directAnnotation).
ACSL4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ACSL4	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ACSL4	transfac_pro__M01253	CNOT3 (directAnnotation).
ACSL4	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ACSL4	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ACSL4	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ACSL4	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ACSL4	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ACSL4	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ACSL4	cisbp__M00968	MTF2 (directAnnotation).
ACSL4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ACSL4	metacluster_7.13	ZFX (directAnnotation).
ACSL4	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ACSL4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ACSL4	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ACSL4	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ACSL4	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ACSL4	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ACSL4	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ACSL4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ACSL4	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ACSL4	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ACSL4	transfac_pro__M07310	SP5 (directAnnotation).
ACSL4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ACSL4	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ACSL4	transfac_pro__M00938	E2F1 (directAnnotation).
ACSL4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ACSL4	transfac_pro__M04893	TAF1 (directAnnotation).
ACSL4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ACSL4	transfac_pro__M04817	ZBTB33 (directAnnotation).
ACSL4	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ACSL4	transfac_pro__M12697	ZNF142 (directAnnotation).
ACSL4	metacluster_175.1	ZNF283 (directAnnotation).
ACSL4	cisbp__M00788	ZFY (inferredBy_Orthology).
ACSL4	tfdimers__MD00364	WT1 (directAnnotation).
ACSL4	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ACSL4	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ACSL4	hdpi__ZNF304	ZNF304 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ACSL4	"Icosapent"	DB00159	small molecule
ACSL4	"Rosiglitazone"	DB00412	small molecule
ACSL4	"Troglitazone"	DB00197	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."