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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ACSL1

Summary for ACSL1

Gene information	Gene symbol	ACSL1
	Ensembl ID	ENSG00000151726
	Entrez ID	2180
	Gene name	acyl-CoA synthetase long chain family member 1
	Synonyms	ACS1\|FACL1\|FACL2\|LACS\|LACS1\|LACS2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ACSL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.254912	8.36e-07
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.330865	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.425555	3.76e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.791647	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.280978	6.61e-05
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.758098	0.00e+00

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Expression of ACSL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACSL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACSL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACSL1	hsa-miR-449a	80.8954	NM_001286708
ACSL1	hsa-miR-449b-5p	80.8954	NM_001286708
ACSL1	hsa-miR-34c-5p	80.8954	NM_001286708
ACSL1	hsa-miR-6840-3p	80.6333	NM_001995
ACSL1	hsa-miR-3163	80.2314	NM_001995
ACSL1	hsa-miR-4276	80.1433	NM_001995

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Motifs and transcription factors (TFs) regulating ACSL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACSL1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ACSL1	transfac_pro__M00652	NRF1 (directAnnotation).
ACSL1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ACSL1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ACSL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ACSL1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ACSL1	jaspar__MA1721.1	ZNF93 (directAnnotation).
ACSL1	metacluster_151.2	ZNF23 (directAnnotation).
ACSL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ACSL1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ACSL1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ACSL1	transfac_pro__M01199	TRIM28 (directAnnotation).
ACSL1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ACSL1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ACSL1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ACSL1	transfac_pro__M01253	CNOT3 (directAnnotation).
ACSL1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ACSL1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ACSL1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ACSL1	cisbp__M00968	MTF2 (directAnnotation).
ACSL1	metacluster_7.13	ZFX (directAnnotation).
ACSL1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ACSL1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ACSL1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ACSL1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ACSL1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ACSL1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ACSL1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ACSL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ACSL1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ACSL1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ACSL1	transfac_pro__M07310	SP5 (directAnnotation).
ACSL1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ACSL1	transfac_pro__M00938	E2F1 (directAnnotation).
ACSL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ACSL1	transfac_pro__M04893	TAF1 (directAnnotation).
ACSL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ACSL1	transfac_pro__M04817	ZBTB33 (directAnnotation).
ACSL1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ACSL1	transfac_pro__M12697	ZNF142 (directAnnotation).
ACSL1	metacluster_175.1	ZNF283 (directAnnotation).
ACSL1	cisbp__M00788	ZFY (inferredBy_Orthology).
ACSL1	tfdimers__MD00364	WT1 (directAnnotation).
ACSL1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ACSL1	hdpi__ZNF304	ZNF304 (directAnnotation).
ACSL1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ACSL1	transfac_pro__M04916	TAF1 (directAnnotation).
ACSL1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ACSL1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ACSL1	tfdimers__MD00483	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ACSL1	"Adenosine phosphate"	DB00131	small molecule
ACSL1	"ATP"	DB00171	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."