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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF217

Summary for ZNF217

Gene information	Gene symbol	ZNF217
	Ensembl ID	ENSG00000171940
	Entrez ID	7764
	Gene name	zinc finger protein 217
	Synonyms	ZABC1
	Gene type	protein_coding
	UniProtAcc	O75362

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Dataset with differentially expressed gene: ZNF217

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.537535	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.281272	3.69e-28
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.295319	3.25e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.371787	1.20e-17

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Expression of ZNF217 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF217

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ZNF217	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating ZNF217

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF217	hsa-miR-5002-5p	99.1408	NM_006526
ZNF217	hsa-miR-19b-3p	97.2197	NM_006526
ZNF217	hsa-miR-19a-3p	97.2197	NM_006526
ZNF217	hsa-miR-150-3p	95.9892	NM_006526
ZNF217	hsa-miR-558	95.9154	NM_006526
ZNF217	hsa-miR-130b-3p	95.0519	NM_006526
ZNF217	hsa-miR-454-3p	94.5768	NM_006526
ZNF217	hsa-miR-6512-3p	94.2967	NM_006526
ZNF217	hsa-miR-6720-5p	94.2967	NM_006526
ZNF217	hsa-miR-301b-3p	94.2088	NM_006526
ZNF217	hsa-miR-4295	94.2088	NM_006526
ZNF217	hsa-miR-3666	94.2088	NM_006526
ZNF217	hsa-miR-130a-3p	94.2088	NM_006526
ZNF217	hsa-miR-301a-3p	94.2088	NM_006526
ZNF217	hsa-miR-548aa	91.7913	NM_006526
ZNF217	hsa-miR-548t-3p	91.7913	NM_006526
ZNF217	hsa-miR-548ap-3p	91.7913	NM_006526
ZNF217	hsa-miR-24-3p	91.5852	NM_006526
ZNF217	hsa-miR-5585-5p	90.5279	NM_006526
ZNF217	hsa-miR-4255	89.1037	NM_006526
ZNF217	hsa-miR-211-3p	88.5873	NM_006526
ZNF217	hsa-miR-4803	88.4501	NM_006526
ZNF217	hsa-miR-548as-3p	88.4093	NM_006526
ZNF217	hsa-miR-3163	88.0708	NM_006526
ZNF217	hsa-miR-200b-3p	88.0037	NM_006526
ZNF217	hsa-miR-429	88.0037	NM_006526
ZNF217	hsa-miR-200c-3p	88.0037	NM_006526
ZNF217	hsa-miR-4446-3p	87.2535	NM_006526
ZNF217	hsa-miR-8063	86.9874	NM_006526
ZNF217	hsa-miR-548ao-5p	86.9297	NM_006526
ZNF217	hsa-miR-548ax	86.9297	NM_006526
ZNF217	hsa-miR-12129	85.7723	NM_006526
ZNF217	hsa-miR-548az-5p	85.3858	NM_006526
ZNF217	hsa-miR-548t-5p	85.3858	NM_006526
ZNF217	hsa-miR-548g-5p	85.3508	NM_006526
ZNF217	hsa-miR-548aj-5p	85.3508	NM_006526
ZNF217	hsa-miR-548x-5p	85.3508	NM_006526
ZNF217	hsa-miR-548f-5p	85.3508	NM_006526
ZNF217	hsa-miR-519b-3p	85.0211	NM_006526
ZNF217	hsa-miR-519c-3p	85.0211	NM_006526
ZNF217	hsa-miR-519a-3p	85.0211	NM_006526
ZNF217	hsa-miR-1468-3p	84.8878	NM_006526
ZNF217	hsa-miR-1263	84.7666	NM_006526
ZNF217	hsa-miR-1303	84.6952	NM_006526
ZNF217	hsa-miR-199a-3p	83.2574	NM_006526
ZNF217	hsa-miR-3129-5p	83.2574	NM_006526
ZNF217	hsa-miR-199b-3p	83.2574	NM_006526
ZNF217	hsa-miR-3679-3p	83.2376	NM_006526
ZNF217	hsa-miR-499a-5p	83.1356	NM_006526
ZNF217	hsa-miR-137-3p	81.7625	NM_006526

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Motifs and transcription factors (TFs) regulating ZNF217

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF217	transfac_pro__M02089	E2F3 (directAnnotation).
ZNF217	transfac_pro__M01122	ZNF219 (directAnnotation).
ZNF217	metacluster_44.7	NKX3-2 (directAnnotation).
ZNF217	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ZNF217	cisbp__M00249	WT1 (directAnnotation).
ZNF217	transfac_pro__M01303	SP1 (directAnnotation).
ZNF217	transfac_pro__M04595	SALL2 (directAnnotation).
ZNF217	transfac_pro__M12686	ZBTB10 (directAnnotation).
ZNF217	transfac_pro__M00986	CHURC1 (directAnnotation).
ZNF217	transfac_pro__M01298	MECP2 (directAnnotation).
ZNF217	transfac_pro__M04918	EGR1 (directAnnotation).
ZNF217	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ZNF217	jaspar__MA0502.2	NFYB (directAnnotation).
ZNF217	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ZNF217	metacluster_7.13	ZFX (directAnnotation).
ZNF217	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ZNF217	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZNF217	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZNF217	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZNF217	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZNF217	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZNF217	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."