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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF148

Summary for ZNF148

Gene information	Gene symbol	ZNF148
	Ensembl ID	ENSG00000163848
	Entrez ID	7707
	Gene name	zinc finger protein 148
	Synonyms	BERF-1\|BFCOL1\|HT-BETA\|pHZ-52\|ZBP-89\|ZFP148
	Gene type	protein_coding
	UniProtAcc	Q9UQR1

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Dataset with differentially expressed gene: ZNF148

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.398589	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.567839	0.00e+00

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Expression of ZNF148 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF148

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF148

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF148	hsa-miR-3646	99.3048	NM_021964
ZNF148	hsa-miR-548c-3p	98.8057	NM_021964
ZNF148	hsa-miR-548x-3p	98.5063	NM_021964
ZNF148	hsa-miR-548aj-3p	98.5063	NM_021964
ZNF148	hsa-miR-3679-3p	97.9749	NM_021964
ZNF148	hsa-miR-548ae-3p	97.8778	NM_021964
ZNF148	hsa-miR-548aq-3p	97.8778	NM_021964
ZNF148	hsa-miR-12124	97.752	NM_021964
ZNF148	hsa-miR-548ah-3p	97.679	NM_021964
ZNF148	hsa-miR-548am-3p	97.679	NM_021964
ZNF148	hsa-miR-548j-3p	97.679	NM_021964
ZNF148	hsa-miR-4496	97.0798	NM_021964
ZNF148	hsa-miR-5700	96.7107	NM_021964
ZNF148	hsa-miR-513a-3p	96.4746	NM_021964
ZNF148	hsa-miR-513c-3p	96.4746	NM_021964
ZNF148	hsa-miR-3662	96.1684	NM_021964
ZNF148	hsa-miR-203a-3p	95.9841	NM_021964
ZNF148	hsa-miR-548h-3p	95.8461	NM_021964
ZNF148	hsa-miR-548z	95.8461	NM_021964
ZNF148	hsa-miR-323a-3p	95.7577	NM_021964
ZNF148	hsa-miR-4760-5p	95.7259	NM_021964
ZNF148	hsa-miR-539-5p	95.5964	NM_021964
ZNF148	hsa-miR-548ac	95.4835	NM_021964
ZNF148	hsa-miR-1468-3p	95.2515	NM_021964
ZNF148	hsa-miR-3606-3p	95.1587	NM_021964
ZNF148	hsa-let-7c-3p	94.9496	NM_021964
ZNF148	hsa-miR-8063	94.6395	NM_021964
ZNF148	hsa-miR-5582-3p	94.3511	NM_021964
ZNF148	hsa-miR-365b-3p	94.2761	NM_021964
ZNF148	hsa-miR-365a-3p	94.2761	NM_021964
ZNF148	hsa-miR-548bb-3p	94.2457	NM_021964
ZNF148	hsa-miR-298	94.0126	NM_021964
ZNF148	hsa-miR-4698	93.8507	NM_021964
ZNF148	hsa-miR-548d-3p	93.7433	NM_021964
ZNF148	hsa-miR-8061	93.6418	NM_021964
ZNF148	hsa-miR-4728-3p	93.2651	NM_021964
ZNF148	hsa-miR-559	93.2205	NM_021964
ZNF148	hsa-miR-3622b-3p	92.4597	NM_021964
ZNF148	hsa-miR-3622a-3p	92.4597	NM_021964
ZNF148	hsa-miR-216b-5p	92.2978	NM_021964
ZNF148	hsa-miR-3192-3p	91.8147	NM_021964
ZNF148	hsa-miR-4795-3p	91.8115	NM_021964
ZNF148	hsa-miR-33a-3p	91.731	NM_021964
ZNF148	hsa-miR-12116	91.7291	NM_021964
ZNF148	hsa-miR-548ar-3p	91.1893	NM_021964
ZNF148	hsa-miR-4699-3p	91.0779	NM_021964
ZNF148	hsa-miR-6835-3p	90.8628	NM_021964
ZNF148	hsa-miR-5087	90.6037	NM_021964
ZNF148	hsa-miR-548ak	90.5466	NM_021964
ZNF148	hsa-miR-548ar-5p	90.5466	NM_021964

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Motifs and transcription factors (TFs) regulating ZNF148

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF148	metacluster_7.13	ZFX (directAnnotation).
ZNF148	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZNF148	metacluster_151.2	ZNF23 (directAnnotation).
ZNF148	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ZNF148	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZNF148	metacluster_182.10	ZFX (directAnnotation).
ZNF148	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZNF148	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZNF148	cisbp__M00968	MTF2 (directAnnotation).
ZNF148	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZNF148	cisbp__M00341	PAX6 (directAnnotation).
ZNF148	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZNF148	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZNF148	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZNF148	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZNF148	cisbp__M00788	ZFY (inferredBy_Orthology).
ZNF148	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ZNF148	hdpi__ZNF304	ZNF304 (directAnnotation).
ZNF148	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZNF148	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZNF148	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZNF148	transfac_pro__M01199	TRIM28 (directAnnotation).
ZNF148	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ZNF148	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZNF148	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF148	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZNF148	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."