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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YIPF6

Summary for YIPF6

Gene information	Gene symbol	YIPF6
	Ensembl ID	ENSG00000181704
	Entrez ID	286451
	Gene name	Yip1 domain family member 6
	Synonyms	FinGER6\|MGC21416
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: YIPF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.422749	3.50e-30
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.508205	9.18e-26
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.451902	1.61e-25
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.386085	2.07e-26

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Expression of YIPF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YIPF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YIPF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YIPF6	hsa-miR-4795-3p	99.7383	NM_001195214
YIPF6	hsa-miR-551b-5p	99.0733	NM_001195214
YIPF6	hsa-miR-126-5p	98.656	NM_001195214
YIPF6	hsa-miR-4694-3p	97.9614	NM_001195214
YIPF6	hsa-miR-3942-3p	97.2482	NM_001195214
YIPF6	hsa-miR-95-5p	97.1677	NM_001195214
YIPF6	hsa-miR-5589-3p	96.8453	NM_001195214
YIPF6	hsa-miR-4326	95.3131	NM_001195214
YIPF6	hsa-miR-6891-5p	95.0624	NM_001195214
YIPF6	hsa-miR-4427	93.8204	NM_001195214
YIPF6	hsa-miR-4698	93.5901	NM_001195214
YIPF6	hsa-miR-3646	93.3214	NM_001195214
YIPF6	hsa-miR-3662	93.3191	NM_001195214
YIPF6	hsa-miR-576-5p	92.5668	NM_001195214
YIPF6	hsa-miR-12118	92.5324	NM_001195214
YIPF6	hsa-miR-6841-5p	92.4996	NM_001195214
YIPF6	hsa-miR-3173-3p	92.4814	NM_001195214
YIPF6	hsa-miR-664a-3p	92.379	NM_001195214
YIPF6	hsa-miR-653-3p	91.7897	NM_001195214
YIPF6	hsa-miR-4720-3p	91.469	NM_001195214
YIPF6	hsa-miR-4676-3p	91.2762	NM_001195214
YIPF6	hsa-miR-892c-3p	91.2762	NM_001195214
YIPF6	hsa-miR-452-5p	91.2089	NM_001195214
YIPF6	hsa-miR-548aj-3p	91.0554	NM_001195214
YIPF6	hsa-miR-548x-3p	91.0554	NM_001195214
YIPF6	hsa-miR-10398-5p	90.7839	NM_001195214
YIPF6	hsa-miR-607	90.1277	NM_001195214
YIPF6	hsa-miR-892c-5p	89.7906	NM_001195214
YIPF6	hsa-miR-548ae-3p	88.7939	NM_001195214
YIPF6	hsa-miR-548aq-3p	88.7939	NM_001195214
YIPF6	hsa-miR-3121-3p	88.663	NM_001195214
YIPF6	hsa-miR-664b-3p	88.5896	NM_001195214
YIPF6	hsa-miR-579-3p	88.5896	NM_001195214
YIPF6	hsa-miR-6884-5p	88.0121	NM_001195214
YIPF6	hsa-miR-584-3p	87.9478	NM_001195214
YIPF6	hsa-miR-499a-5p	87.8056	NM_001195214
YIPF6	hsa-miR-548j-3p	86.6907	NM_001195214
YIPF6	hsa-miR-548ah-3p	86.6907	NM_001195214
YIPF6	hsa-miR-548am-3p	86.6907	NM_001195214
YIPF6	hsa-miR-1275	86.4462	NM_001195214
YIPF6	hsa-miR-335-3p	86.3343	NM_001195214
YIPF6	hsa-miR-6879-3p	86.2632	NM_001195214
YIPF6	hsa-miR-9983-3p	86.0635	NM_001195214
YIPF6	hsa-miR-514a-5p	86.0226	NM_001195214
YIPF6	hsa-miR-4251	85.6219	NM_001195214
YIPF6	hsa-miR-6878-5p	85.5454	NM_001195214
YIPF6	hsa-miR-485-5p	85.5079	NM_001195214
YIPF6	hsa-miR-6758-3p	84.808	NM_001195214
YIPF6	hsa-miR-548c-3p	84.6233	NM_001195214
YIPF6	hsa-miR-450b-5p	84.597	NM_001195214

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Motifs and transcription factors (TFs) regulating YIPF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YIPF6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
YIPF6	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
YIPF6	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
YIPF6	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
YIPF6	metacluster_81.7	CREB1 (directAnnotation).
YIPF6	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."