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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WAPL

Summary for WAPL

Gene information	Gene symbol	WAPL
	Ensembl ID	ENSG00000062650
	Entrez ID	23063
	Gene name	WAPL cohesin release factor
	Synonyms	FOE\|KIAA0261\|WAPAL
	Gene type	protein_coding
	UniProtAcc	Q7Z5K2

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Dataset with differentially expressed gene: WAPL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.276312	7.00e-19

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Expression of WAPL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WAPL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WAPL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WAPL	hsa-miR-548n	99.6544	NM_001318328
WAPL	hsa-miR-3163	99.0872	NM_001318328
WAPL	hsa-miR-4735-5p	98.6355	NM_001318328
WAPL	hsa-miR-4699-3p	98.5727	NM_001318328
WAPL	hsa-miR-20a-3p	97.3018	NM_001318328
WAPL	hsa-miR-3148	97.1812	NM_001318328
WAPL	hsa-miR-590-3p	96.8647	NM_001318328
WAPL	hsa-miR-4307	96.5223	NM_001318328
WAPL	hsa-miR-194-5p	95.9449	NM_001318328
WAPL	hsa-miR-300	95.0203	NM_001318328
WAPL	hsa-miR-381-3p	95.0203	NM_001318328
WAPL	hsa-miR-5582-3p	94.7664	NM_001318328
WAPL	hsa-miR-429	94.2324	NM_001318328
WAPL	hsa-miR-548e-5p	94.0461	NM_001318328
WAPL	hsa-miR-7159-5p	94.045	NM_001318328
WAPL	hsa-miR-200b-3p	93.195	NM_001318328
WAPL	hsa-miR-200c-3p	93.195	NM_001318328
WAPL	hsa-miR-4724-5p	92.9006	NM_001318328
WAPL	hsa-miR-6730-5p	92.8072	NM_001318328
WAPL	hsa-miR-4719	92.607	NM_001318328
WAPL	hsa-miR-217-5p	92.4557	NM_001318328
WAPL	hsa-miR-6870-3p	92.3556	NM_001318328
WAPL	hsa-miR-4727-5p	92.2326	NM_001318328
WAPL	hsa-miR-135a-5p	92.1184	NM_001318328
WAPL	hsa-miR-135b-5p	92.1184	NM_001318328
WAPL	hsa-miR-6817-5p	92.0927	NM_001318328
WAPL	hsa-miR-4769-3p	92.0927	NM_001318328
WAPL	hsa-miR-199a-5p	92.0685	NM_001318328
WAPL	hsa-miR-199b-5p	92.0685	NM_001318328
WAPL	hsa-miR-651-3p	91.9277	NM_001318328
WAPL	hsa-miR-10527-5p	91.8778	NM_001318328
WAPL	hsa-miR-3129-3p	91.7734	NM_001318328
WAPL	hsa-miR-5583-5p	91.7734	NM_001318328
WAPL	hsa-miR-4293	91.7512	NM_001318328
WAPL	hsa-miR-6507-5p	91.6357	NM_001318328
WAPL	hsa-miR-7154-5p	91.3798	NM_001318328
WAPL	hsa-miR-10523-5p	91.3408	NM_001318328
WAPL	hsa-miR-10522-5p	91.2326	NM_001318328
WAPL	hsa-miR-548ar-3p	91.0533	NM_001318328
WAPL	hsa-miR-539-5p	91.0135	NM_001318328
WAPL	hsa-miR-3688-3p	90.8878	NM_001318328
WAPL	hsa-miR-4518	90.6326	NM_001318328
WAPL	hsa-miR-1266-5p	90.6326	NM_001318328
WAPL	hsa-miR-548a-3p	90.4412	NM_001318328
WAPL	hsa-miR-548bc	90.4412	NM_001318328
WAPL	hsa-miR-548f-3p	90.4412	NM_001318328
WAPL	hsa-miR-548az-3p	90.4412	NM_001318328
WAPL	hsa-miR-548e-3p	90.4412	NM_001318328
WAPL	hsa-miR-5004-3p	90.199	NM_001318328
WAPL	hsa-miR-548c-3p	89.8892	NM_001318328

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Motifs and transcription factors (TFs) regulating WAPL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WAPL	metacluster_135.11	NR2C2 (directAnnotation).
WAPL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
WAPL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
WAPL	metacluster_7.13	ZFX (directAnnotation).
WAPL	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
WAPL	cisbp__M00968	MTF2 (directAnnotation).
WAPL	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WAPL	cisbp__M00341	PAX6 (directAnnotation).
WAPL	metacluster_198.3	ZFP64 (directAnnotation).
WAPL	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
WAPL	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
WAPL	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
WAPL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
WAPL	cisbp__M00788	ZFY (inferredBy_Orthology).
WAPL	metacluster_175.1	ZNF283 (directAnnotation).
WAPL	hdpi__ZNF304	ZNF304 (directAnnotation).
WAPL	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
WAPL	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
WAPL	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
WAPL	transfac_pro__M01199	TRIM28 (directAnnotation).
WAPL	metacluster_151.2	ZNF23 (directAnnotation).
WAPL	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WAPL	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
WAPL	transfac_pro__M03806	ZBTB7C (directAnnotation).
WAPL	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."