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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: VKORC1L1

Summary for VKORC1L1

Gene information	Gene symbol	VKORC1L1
	Ensembl ID	ENSG00000196715
	Entrez ID	154807
	Gene name	vitamin K epoxide reductase complex subunit 1 like 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VKORC1L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.433982	3.87e-35
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.671743	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.435028	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.37048	0.00e+00

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Expression of VKORC1L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VKORC1L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VKORC1L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VKORC1L1	hsa-miR-3973	98.9653	NM_001284342
VKORC1L1	hsa-miR-3658	98.5075	NM_001284342
VKORC1L1	hsa-miR-3144-3p	98.1537	NM_001284342
VKORC1L1	hsa-miR-3662	97.2946	NM_001284342
VKORC1L1	hsa-miR-144-3p	96.8602	NM_001284342
VKORC1L1	hsa-miR-4735-5p	96.6364	NM_001284342
VKORC1L1	hsa-miR-548at-5p	96.3018	NM_001284342
VKORC1L1	hsa-miR-4789-5p	96.0905	NM_001284342
VKORC1L1	hsa-miR-4328	95.1654	NM_173517
VKORC1L1	hsa-miR-1468-3p	94.6124	NM_173517
VKORC1L1	hsa-miR-1305	94.4435	NM_001284342
VKORC1L1	hsa-miR-519e-5p	94.2185	NM_001284342
VKORC1L1	hsa-miR-515-5p	94.2185	NM_001284342
VKORC1L1	hsa-miR-3611	94.05	NM_173517
VKORC1L1	hsa-miR-4699-3p	94.0136	NM_173517
VKORC1L1	hsa-miR-23c	93.52	NM_173517
VKORC1L1	hsa-miR-23b-3p	93.52	NM_173517
VKORC1L1	hsa-miR-23a-3p	93.52	NM_173517
VKORC1L1	hsa-miR-655-3p	92.8796	NM_001284342
VKORC1L1	hsa-miR-374c-5p	92.8796	NM_001284342
VKORC1L1	hsa-miR-942-3p	92.8373	NM_173517
VKORC1L1	hsa-miR-4742-3p	92.1799	NM_001284342
VKORC1L1	hsa-miR-26a-2-3p	91.9067	NM_001284342
VKORC1L1	hsa-miR-26a-1-3p	91.9067	NM_001284342
VKORC1L1	hsa-miR-548p	91.8232	NM_173517
VKORC1L1	hsa-miR-642b-3p	91.439	NM_001284342
VKORC1L1	hsa-miR-642a-3p	91.439	NM_001284342
VKORC1L1	hsa-miR-4486	91.0661	NM_001284342
VKORC1L1	hsa-miR-5580-3p	90.9957	NM_001284342
VKORC1L1	hsa-miR-6504-3p	90.8979	NM_001284342
VKORC1L1	hsa-miR-5582-3p	90.255	NM_001284342
VKORC1L1	hsa-miR-3158-5p	89.8605	NM_173517
VKORC1L1	hsa-miR-875-5p	89.3199	NM_001284342
VKORC1L1	hsa-miR-548d-3p	89.0678	NM_173517
VKORC1L1	hsa-miR-5088-3p	88.8859	NM_173517
VKORC1L1	hsa-miR-548g-3p	88.5378	NM_173517
VKORC1L1	hsa-miR-6756-3p	88.4293	NM_173517
VKORC1L1	hsa-miR-3127-3p	88.4293	NM_173517
VKORC1L1	hsa-miR-10399-5p	88.3391	NM_001284342
VKORC1L1	hsa-miR-548z	88.068	NM_173517
VKORC1L1	hsa-miR-548ac	88.068	NM_173517
VKORC1L1	hsa-miR-548bb-3p	88.068	NM_173517
VKORC1L1	hsa-miR-548h-3p	88.068	NM_173517
VKORC1L1	hsa-miR-548x-3p	87.4914	NM_173517
VKORC1L1	hsa-miR-548aj-3p	87.4914	NM_173517
VKORC1L1	hsa-miR-9851-3p	87.2891	NM_173517
VKORC1L1	hsa-miR-584-3p	87.2022	NM_001284342
VKORC1L1	hsa-miR-593-5p	85.9531	NM_173517
VKORC1L1	hsa-miR-548c-3p	85.5554	NM_173517
VKORC1L1	hsa-miR-548g-5p	84.8851	NM_173517

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Motifs and transcription factors (TFs) regulating VKORC1L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VKORC1L1	metacluster_7.13	ZFX (directAnnotation).
VKORC1L1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
VKORC1L1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
VKORC1L1	metacluster_151.2	ZNF23 (directAnnotation).
VKORC1L1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
VKORC1L1	transfac_pro__M05479	ZNF580 (directAnnotation).
VKORC1L1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
VKORC1L1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
VKORC1L1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
VKORC1L1	metacluster_182.10	ZFX (directAnnotation).
VKORC1L1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
VKORC1L1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
VKORC1L1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
VKORC1L1	jaspar__MA0079.5	SP1 (directAnnotation).
VKORC1L1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
VKORC1L1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
VKORC1L1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
VKORC1L1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
VKORC1L1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
VKORC1L1	transfac_pro__M00652	NRF1 (directAnnotation).
VKORC1L1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
VKORC1L1	transfac_pro__M04866	HDAC2 (directAnnotation).
VKORC1L1	jaspar__MA1122.1	TFDP1 (directAnnotation).
VKORC1L1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
VKORC1L1	transfac_pro__M04918	EGR1 (directAnnotation).
VKORC1L1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
VKORC1L1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
VKORC1L1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
VKORC1L1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
VKORC1L1	cisbp__M00249	WT1 (directAnnotation).
VKORC1L1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
VKORC1L1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
VKORC1L1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
VKORC1L1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
VKORC1L1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
VKORC1L1	"Menadione"	DB00170	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."