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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE3C

Summary for UBE3C

Gene information	Gene symbol	UBE3C
	Ensembl ID	ENSG00000009335
	Entrez ID	9690
	Gene name	ubiquitin protein ligase E3C
	Synonyms	KIAA0010\|KIAA10
	Gene type	protein_coding
	UniProtAcc	Q15386

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Dataset with differentially expressed gene: UBE3C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.30767	3.06e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.326703	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.308819	1.76e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.348883	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.481556	0.00e+00

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Expression of UBE3C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE3C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE3C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE3C	hsa-miR-9-5p	97.6697	NM_014671
UBE3C	hsa-miR-4719	97.4513	NM_014671
UBE3C	hsa-miR-659-3p	95.6989	NM_014671
UBE3C	hsa-let-7a-3p	95.2303	NM_014671
UBE3C	hsa-let-7f-1-3p	95.2303	NM_014671
UBE3C	hsa-miR-98-3p	95.2303	NM_014671
UBE3C	hsa-let-7b-3p	95.2303	NM_014671
UBE3C	hsa-miR-548e-5p	95.0918	NM_014671
UBE3C	hsa-miR-137-3p	94.1197	NM_014671
UBE3C	hsa-miR-135b-5p	94.0456	NM_014671
UBE3C	hsa-miR-135a-5p	94.0456	NM_014671
UBE3C	hsa-miR-3163	93.7817	NM_014671
UBE3C	hsa-miR-5197-3p	92.5353	NM_014671
UBE3C	hsa-miR-6835-3p	91.8782	NM_014671
UBE3C	hsa-miR-548c-3p	91.1684	NM_014671
UBE3C	hsa-miR-106b-5p	91.0299	NM_014671
UBE3C	hsa-miR-20a-5p	91.0299	NM_014671
UBE3C	hsa-miR-4668-5p	90.829	NM_014671
UBE3C	hsa-miR-519d-3p	90.3847	NM_014671
UBE3C	hsa-miR-106a-5p	90.3847	NM_014671
UBE3C	hsa-miR-526b-3p	90.3847	NM_014671
UBE3C	hsa-miR-93-5p	90.3847	NM_014671
UBE3C	hsa-miR-17-5p	90.3847	NM_014671
UBE3C	hsa-miR-20b-5p	90.3847	NM_014671
UBE3C	hsa-miR-4795-3p	90.377	NM_014671
UBE3C	hsa-miR-548t-5p	88.9798	NM_014671
UBE3C	hsa-miR-548az-5p	88.9798	NM_014671
UBE3C	hsa-miR-4639-5p	88.0406	NM_014671
UBE3C	hsa-miR-497-3p	86.8597	NM_014671
UBE3C	hsa-miR-1185-2-3p	86.4988	NM_014671
UBE3C	hsa-miR-4789-5p	86.4988	NM_014671
UBE3C	hsa-let-7f-2-3p	86.4988	NM_014671
UBE3C	hsa-miR-1185-1-3p	86.4988	NM_014671
UBE3C	hsa-miR-12115	86.4828	NM_014671
UBE3C	hsa-miR-4328	86.3001	NM_014671
UBE3C	hsa-miR-4714-3p	86.0823	NM_014671
UBE3C	hsa-miR-4645-3p	86.0816	NM_014671
UBE3C	hsa-miR-5692a	86.0518	NM_014671
UBE3C	hsa-miR-2110	85.8488	NM_014671
UBE3C	hsa-miR-30c-5p	85.7794	NM_014671
UBE3C	hsa-miR-30e-5p	85.7794	NM_014671
UBE3C	hsa-miR-30a-5p	85.7794	NM_014671
UBE3C	hsa-miR-30d-5p	85.7794	NM_014671
UBE3C	hsa-miR-30b-5p	85.7794	NM_014671
UBE3C	hsa-miR-4269	85.4333	NM_014671
UBE3C	hsa-miR-6715b-5p	85.4333	NM_014671
UBE3C	hsa-miR-3129-3p	85.0364	NM_014671
UBE3C	hsa-miR-5583-5p	85.0364	NM_014671
UBE3C	hsa-miR-2052	84.6257	NM_014671
UBE3C	hsa-miR-8084	83.6117	NM_014671

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Motifs and transcription factors (TFs) regulating UBE3C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE3C	metacluster_7.13	ZFX (directAnnotation).
UBE3C	cisbp__M01863	ZNF711 (inferredBy_Orthology).
UBE3C	metacluster_151.2	ZNF23 (directAnnotation).
UBE3C	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
UBE3C	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBE3C	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBE3C	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
UBE3C	transfac_pro__M04950	EGR1 (directAnnotation).
UBE3C	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
UBE3C	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBE3C	transfac_pro__M00652	NRF1 (directAnnotation).
UBE3C	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
UBE3C	transfac_pro__M04866	HDAC2 (directAnnotation).
UBE3C	jaspar__MA1122.1	TFDP1 (directAnnotation).
UBE3C	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
UBE3C	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
UBE3C	cisbp__M00968	MTF2 (directAnnotation).
UBE3C	cisbp__M00341	PAX6 (directAnnotation).
UBE3C	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UBE3C	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UBE3C	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBE3C	cisbp__M00788	ZFY (inferredBy_Orthology).
UBE3C	metacluster_175.1	ZNF283 (directAnnotation).
UBE3C	hdpi__ZNF304	ZNF304 (directAnnotation).
UBE3C	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBE3C	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBE3C	transfac_pro__M01199	TRIM28 (directAnnotation).
UBE3C	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBE3C	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBE3C	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBE3C	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE3C	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UBE3C	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
UBE3C	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
UBE3C	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
UBE3C	transfac_pro__M01253	CNOT3 (directAnnotation).
UBE3C	transfac_pro__M04817	ZBTB33 (directAnnotation).
UBE3C	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."