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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: TWF1

Summary for TWF1

Gene informationGene symbol

TWF1

Ensembl ID

ENSG00000151239

Entrez ID

5756

Gene nametwinfilin actin binding protein 1
SynonymsA6|PTK9
Gene typeprotein_coding
UniProtAcc

Q12792


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Dataset with differentially expressed gene: TWF1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-0.2978960.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.4012081.14e-43

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Expression of TWF1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to TWF1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

TWF1

Unusual Activation of Pro-survival Pathway
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MicroRNAs (miRNA) regulating TWF1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
TWF1hsa-miR-30d-5p99.6677NM_001242397
TWF1hsa-miR-30e-5p99.6677NM_001242397
TWF1hsa-miR-30c-5p99.6677NM_001242397
TWF1hsa-miR-30a-5p99.6677NM_001242397
TWF1hsa-miR-30b-5p99.6677NM_001242397
TWF1hsa-miR-316399.4753NM_001242397
TWF1hsa-miR-590-3p98.2171NM_002822
TWF1hsa-miR-142-3p98.2072NM_001242397
TWF1hsa-miR-103a-3p98.1894NM_001242397
TWF1hsa-miR-10798.1894NM_001242397
TWF1hsa-miR-1-3p97.6307NM_001242397
TWF1hsa-miR-20697.6307NM_001242397
TWF1hsa-miR-428297.1881NM_001242397
TWF1hsa-miR-138-2-3p96.4483NM_001242397
TWF1hsa-miR-61396.1655NM_001242397
TWF1hsa-miR-432594.6581NM_002822
TWF1hsa-miR-570193.9837NM_002822
TWF1hsa-miR-616-5p93.9069NM_001242397
TWF1hsa-miR-373-5p93.9069NM_001242397
TWF1hsa-miR-371b-5p93.9069NM_001242397
TWF1hsa-miR-477593.8337NM_002822
TWF1hsa-miR-155-5p93.7536NM_002822
TWF1hsa-miR-92b-3p93.5182NM_001242397
TWF1hsa-miR-25-3p93.5182NM_001242397
TWF1hsa-miR-92a-3p93.5182NM_001242397
TWF1hsa-miR-32-5p93.5182NM_001242397
TWF1hsa-miR-367-3p93.5182NM_001242397
TWF1hsa-miR-363-3p93.5182NM_001242397
TWF1hsa-miR-451793.3929NM_002822
TWF1hsa-miR-92493.1289NM_002822
TWF1hsa-miR-607392.9447NM_001242397
TWF1hsa-miR-1213692.5974NM_001242397
TWF1hsa-miR-548k92.5863NM_001242397
TWF1hsa-miR-548av-5p92.5863NM_001242397
TWF1hsa-miR-805492.5863NM_001242397
TWF1hsa-miR-450491.7418NM_002822
TWF1hsa-miR-513a-3p90.758NM_001242397
TWF1hsa-miR-513c-3p90.758NM_001242397
TWF1hsa-miR-129790.6042NM_001242397
TWF1hsa-miR-223-3p89.8805NM_002822
TWF1hsa-miR-4735-3p89.4205NM_001242397
TWF1hsa-miR-392089.3939NM_002822
TWF1hsa-miR-18a-5p89.3759NM_001242397
TWF1hsa-miR-18b-5p89.3759NM_001242397
TWF1hsa-miR-570-3p88.8644NM_001242397
TWF1hsa-miR-453188.385NM_002822
TWF1hsa-miR-26a-5p88.181NM_001242397
TWF1hsa-miR-26b-5p88.181NM_001242397
TWF1hsa-miR-4799-5p87.727NM_002822
TWF1hsa-miR-3689b-5p87.5796NM_002822
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Motifs and transcription factors (TFs) regulating TWF1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
TWF1metacluster_7.13ZFX (directAnnotation).
TWF1cisbp__M01863ZNF711 (inferredBy_Orthology).
TWF1taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
TWF1transfac_pro__M05578ZFP92 (inferredBy_Orthology).
TWF1jaspar__MA1483.2ELF2 (directAnnotation).
TWF1metacluster_151.2ZNF23 (directAnnotation).
TWF1metacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TWF1transfac_pro__M05479ZNF580 (directAnnotation).
TWF1metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TWF1kznf__ZNF783_Imbeault2017_OM_MEMEZNF783 (directAnnotation).
TWF1metacluster_144.3ZNF704; ZNF704 (directAnnotation).
TWF1hdpi__ETV4ETV4 (directAnnotation).
TWF1transfac_pro__M06071ZNF814 (directAnnotation).
TWF1jaspar__MA0748.2YY2 (directAnnotation).
TWF1transfac_pro__M05628ZNF735 (directAnnotation).
TWF1homer__TWVGGTCCGC_HINFPHINFP (directAnnotation).
TWF1metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TWF1taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_reprGCM1; SPDEF (directAnnotation).
TWF1jaspar__MA0079.5SP1 (directAnnotation).
TWF1metacluster_135.11NR2C2 (directAnnotation).
TWF1kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
TWF1cisbp__M00968MTF2 (directAnnotation).
TWF1metacluster_160.20JUND; PRDM15 (directAnnotation).
TWF1cisbp__M00341PAX6 (directAnnotation).
TWF1metacluster_198.3ZFP64 (directAnnotation).
TWF1metacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TWF1metacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TWF1jaspar__MA0185.1DEAF1 (inferredBy_Orthology).
TWF1metacluster_61.1DEAF1; DEAF1 (directAnnotation).
TWF1cisbp__M00788ZFY (inferredBy_Orthology).
TWF1kznf__ZNF213_Schmitges2016_RCADEZNF213 (directAnnotation).
TWF1metacluster_175.1ZNF283 (directAnnotation).
TWF1hdpi__ZNF304ZNF304 (directAnnotation).
TWF1transfac_pro__M02844BCL6B (inferredBy_Orthology).
TWF1metacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TWF1metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TWF1transfac_pro__M01199TRIM28 (directAnnotation).
TWF1transfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TWF1transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TWF1transfac_pro__M03806ZBTB7C (directAnnotation).
TWF1transfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."