Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 0.476799 | 0.00e+00 |
GSE163836 | FCIBC02 cell line | Cell line | Breast cancer | Inflammatory breast cancer | Chemotherapy | paclitaxel | NA | Malignant cells | 0.331218 | 0.00e+00 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | CD8+ T cells | 0.487094 | 3.60e-18 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | CD4+ T cells | 0.405624 | 9.93e-12 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Neutrophils | -0.915179 | 6.09e-34 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | 0.579255 | 1.61e-29 |
GSE168668 | LNCaP cell line | Cell line | Prostate cancer | Prostate cancer | Targeted therapy | enzalutamide | NA | Malignant cells | 0.32896 | 2.80e-45 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | -0.435757 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | pre | NK cells | 0.448168 | 8.33e-09 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | pre | CD4+ T cells | 0.327027 | 3.01e-05 |
GSE161801_IMiD | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | pomalidomide + dexamethasone OR lenalidomide + dexamethasone | pre | Malignant cells | 0.257764 | 0.00e+00 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -1.24839 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | 0.314637 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
TOB1 | taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr | E2F2 (directAnnotation). |
TOB1 | kznf__ZNF25_Imbeault2017_OM_MEME | ZNF25 (directAnnotation). |
TOB1 | taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP | ETV5; HES7 (directAnnotation). |
TOB1 | kznf__ZFP57_Imbeault2017_RP_ChIP-seq | ZFP57 (directAnnotation). |
TOB1 | kznf__ZNF777_Imbeault2017_RP_ChIP-seq | ZNF777 (directAnnotation). |
TOB1 | metacluster_195.2 | EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology). |
TOB1 | metacluster_67.2 | ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology). |
TOB1 | metacluster_3.14 | WT1; WT1 (directAnnotation). |
TOB1 | swissregulon__hs__ZBTB14 | ZBTB14 (directAnnotation). |
TOB1 | cisbp__M07938 | E2F1 (directAnnotation). |
TOB1 | taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr | GCM1; SPDEF (directAnnotation). |
TOB1 | transfac_pro__M01219 | SP1 (directAnnotation). SP3 (inferredBy_Orthology). |
TOB1 | transfac_pro__M07397 | ZNF148 (directAnnotation). |
TOB1 | metacluster_131.7 | EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology). |
TOB1 | metacluster_131.4 | EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation). |
TOB1 | taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth | ZNF281 (directAnnotation). |
TOB1 | metacluster_15.2 | E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology). |
TOB1 | metacluster_7.13 | ZFX (directAnnotation). |
TOB1 | metacluster_3.11 | SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation). |
TOB1 | homer__GGGGGGGG_Maz | MAZ (directAnnotation). |
TOB1 | transfac_pro__M01175 | ZBTB7B (directAnnotation). |
TOB1 | taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth | ZNF460 (directAnnotation). |
TOB1 | tfdimers__MD00151 | CHURC1 (directAnnotation). |
TOB1 | metacluster_3.7 | SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation). |
TOB1 | metacluster_15.1 | E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology). |
TOB1 | transfac_pro__M01303 | SP1 (directAnnotation). |
TOB1 | metacluster_141.5 | NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology). |
TOB1 | swissregulon__hs__CHD1 | CHD1 (directAnnotation). |
TOB1 | transfac_pro__M02090 | E2F4 (directAnnotation). |
TOB1 | transfac_pro__M01714 | KLF15 (directAnnotation). |
TOB1 | metacluster_15.3 | E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology). |
TOB1 | hocomoco__PROX1_HUMAN.H11MO.0.D | PROX1 (directAnnotation). |
TOB1 | transfac_pro__M02089 | E2F3 (directAnnotation). |
TOB1 | metacluster_3.4 | SP1; SP2; SP2; SP3 (directAnnotation). |
TOB1 | hocomoco__EGR4_HUMAN.H11MO.0.D | EGR4 (directAnnotation). |
TOB1 | metacluster_3.5 | KLF14; KLF15; KLF15; KLF16 (directAnnotation). |
TOB1 | homer__GGCGGGAARN_E2F6 | E2F6 (directAnnotation). |
TOB1 | transfac_pro__M07436 | WT1 (directAnnotation). |
TOB1 | transfac_pro__M02281 | SP1 (directAnnotation). |
TOB1 | taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr | ELF1; GCM1 (directAnnotation). |
TOB1 | kznf__ZNF730_Imbeault2017_RP_RCADE | ZNF730 (directAnnotation). |
TOB1 | metacluster_3.3 | KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation). |
TOB1 | transfac_pro__M02898 | SMAD3 (directAnnotation). |
TOB1 | transfac_public__M00491 | PATZ1 (directAnnotation). |
TOB1 | transfac_pro__M07461 | KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation). |
TOB1 | jaspar__MA0039.4 | KLF4 (directAnnotation). |
TOB1 | metacluster_163.1 | KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology). |
TOB1 | tfdimers__MD00457 | SREBF1; SREBF2; ZNF354C (directAnnotation). |
TOB1 | transfac_pro__M04595 | SALL2 (directAnnotation). |
TOB1 | transfac_pro__M04916 | TAF1 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |