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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TGFBR3

Summary for TGFBR3

Gene information	Gene symbol	TGFBR3
	Ensembl ID	ENSG00000069702
	Entrez ID	7049
	Gene name	transforming growth factor beta receptor 3
	Synonyms	betaglycan\|BGCAN
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TGFBR3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.402444	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.269781	4.58e-06
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.324945	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.370514	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.276625	1.34e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.316518	2.60e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.503393	0.00e+00

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Expression of TGFBR3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TGFBR3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TGFBR3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TGFBR3	hsa-miR-5688	97.8748	NM_001195683
TGFBR3	hsa-miR-495-3p	97.8277	NM_001195683
TGFBR3	hsa-miR-7110-3p	97.4156	NM_003243
TGFBR3	hsa-miR-7157-5p	95.9137	NM_001195683
TGFBR3	hsa-miR-4500	95.6039	NM_001195683
TGFBR3	hsa-miR-1277-5p	95.5492	NM_001195683
TGFBR3	hsa-miR-4458	93.9995	NM_001195683
TGFBR3	hsa-let-7d-5p	93.9995	NM_001195683
TGFBR3	hsa-miR-1185-2-3p	93.9408	NM_003243
TGFBR3	hsa-let-7f-2-3p	93.9408	NM_003243
TGFBR3	hsa-miR-1185-1-3p	93.9408	NM_003243
TGFBR3	hsa-miR-4310	93.9329	NM_001195683
TGFBR3	hsa-let-7f-5p	93.8723	NM_001195683
TGFBR3	hsa-let-7e-5p	93.8723	NM_001195683
TGFBR3	hsa-let-7b-5p	93.8723	NM_001195683
TGFBR3	hsa-let-7a-5p	93.8723	NM_001195683
TGFBR3	hsa-miR-98-5p	93.8723	NM_001195683
TGFBR3	hsa-let-7i-5p	93.8723	NM_001195683
TGFBR3	hsa-let-7g-5p	93.8723	NM_001195683
TGFBR3	hsa-let-7c-5p	93.8723	NM_001195683
TGFBR3	hsa-miR-7848-3p	93.6204	NM_003243
TGFBR3	hsa-miR-548ar-3p	92.9983	NM_003243
TGFBR3	hsa-miR-484	92.8686	NM_001195683
TGFBR3	hsa-miR-107	92.2281	NM_001195683
TGFBR3	hsa-miR-103a-3p	92.2281	NM_001195683
TGFBR3	hsa-miR-6794-3p	91.5838	NM_003243
TGFBR3	hsa-miR-101-3p	91.356	NM_003243
TGFBR3	hsa-miR-6715b-3p	91.3017	NM_003243
TGFBR3	hsa-miR-376c-3p	91.2404	NM_001195683
TGFBR3	hsa-miR-3155a	91.1539	NM_001195683
TGFBR3	hsa-miR-3155b	91.1539	NM_001195683
TGFBR3	hsa-miR-196a-1-3p	90.9558	NM_001195683
TGFBR3	hsa-miR-4789-5p	90.7816	NM_003243
TGFBR3	hsa-miR-424-5p	89.6091	NM_001195683
TGFBR3	hsa-miR-15b-5p	89.6091	NM_001195683
TGFBR3	hsa-miR-16-5p	89.6091	NM_001195683
TGFBR3	hsa-miR-497-5p	89.6091	NM_001195683
TGFBR3	hsa-miR-15a-5p	89.6091	NM_001195683
TGFBR3	hsa-miR-195-5p	89.6091	NM_001195683
TGFBR3	hsa-miR-6838-5p	89.6091	NM_001195683
TGFBR3	hsa-miR-1323	89.2959	NM_003243
TGFBR3	hsa-miR-7856-5p	88.8008	NM_003243
TGFBR3	hsa-let-7b-3p	87.9425	NM_003243
TGFBR3	hsa-miR-9985	87.8615	NM_001195683
TGFBR3	hsa-miR-27b-3p	87.8615	NM_001195683
TGFBR3	hsa-miR-27a-3p	87.8615	NM_001195683
TGFBR3	hsa-miR-548f-3p	87.7181	NM_003243
TGFBR3	hsa-miR-548e-3p	87.7181	NM_003243
TGFBR3	hsa-miR-548az-3p	87.7181	NM_003243
TGFBR3	hsa-miR-548a-3p	87.7181	NM_003243

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Motifs and transcription factors (TFs) regulating TGFBR3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TGFBR3	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
TGFBR3	swissregulon__hs__SPI1	SPI1 (directAnnotation).
TGFBR3	transfac_pro__M02269	FEV (directAnnotation).
TGFBR3	metacluster_2.4	ZIM3; ZIM3; ZIM3; ZIM3 (directAnnotation).
TGFBR3	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
TGFBR3	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
TGFBR3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TGFBR3	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TGFBR3	transfac_pro__M04861	SIX5 (directAnnotation).
TGFBR3	transfac_pro__M04826	EP300 (directAnnotation).
TGFBR3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TGFBR3	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
TGFBR3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TGFBR3	transfac_pro__M00652	NRF1 (directAnnotation).
TGFBR3	transfac_pro__M04918	EGR1 (directAnnotation).
TGFBR3	transfac_pro__M06897	ZNF789 (directAnnotation).
TGFBR3	transfac_pro__M01251	E2F1 (directAnnotation).
TGFBR3	cisbp__M01815	CEBPE (inferredBy_Orthology).
TGFBR3	metacluster_11.1	ZNF667 (directAnnotation).
TGFBR3	metacluster_20.5	DLX1; DLX4; DLX4 (directAnnotation).
TGFBR3	cisbp__M00282	PHOX2B (directAnnotation).
TGFBR3	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
TGFBR3	transfac_pro__M06086	ZNF17 (directAnnotation).
TGFBR3	transfac_pro__M06832	PEG3 (directAnnotation).
TGFBR3	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
TGFBR3	transfac_pro__M06249	ZNF616 (directAnnotation).
TGFBR3	swissregulon__hs__FOXO3	FOXO3 (directAnnotation).
TGFBR3	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
TGFBR3	taipale_tf_pairs__PBX4_HOXA10_CCATAAATCA_CAP	HOXA10; PBX4 (directAnnotation).
TGFBR3	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
TGFBR3	metacluster_198.3	ZFP64 (directAnnotation).
TGFBR3	cisbp__M00341	PAX6 (directAnnotation).
TGFBR3	cisbp__M00968	MTF2 (directAnnotation).
TGFBR3	transfac_pro__M00716	ZBTB14 (directAnnotation).
TGFBR3	transfac_pro__M04893	TAF1 (directAnnotation).
TGFBR3	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
TGFBR3	transfac_pro__M04916	TAF1 (directAnnotation).
TGFBR3	transfac_pro__M02089	E2F3 (directAnnotation).
TGFBR3	transfac_pro__M04817	ZBTB33 (directAnnotation).
TGFBR3	transfac_pro__M07310	SP5 (directAnnotation).
TGFBR3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
TGFBR3	hdpi__NRL	NRL (directAnnotation).
TGFBR3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TGFBR3	hdpi__HIP2	UBE2K (directAnnotation).
TGFBR3	transfac_pro__M07387	ZBTB7A (directAnnotation).
TGFBR3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TGFBR3	transfac_pro__M01783	SP2 (directAnnotation).
TGFBR3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TGFBR3	cisbp__M07938	E2F1 (directAnnotation).
TGFBR3	metacluster_7.13	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."