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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STC1

Summary for STC1

Gene information	Gene symbol	STC1
	Ensembl ID	ENSG00000159167
	Entrez ID	6781
	Gene name	stanniocalcin 1
	Synonyms	STC
	Gene type	protein_coding
	UniProtAcc	P52823

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Dataset with differentially expressed gene: STC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	7.29409	2.87e-28
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.840049	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.308792	1.09e-16
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.268969	2.83e-09
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.398453	0.00e+00

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Expression of STC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STC1	hsa-miR-101-3p	99.9262	NM_003155
STC1	hsa-miR-5002-5p	98.5266	NM_003155
STC1	hsa-miR-9-3p	97.3908	NM_003155
STC1	hsa-miR-3617-5p	97.2763	NM_003155
STC1	hsa-miR-641	97.2763	NM_003155
STC1	hsa-miR-4795-3p	97.1879	NM_003155
STC1	hsa-miR-340-5p	97.0545	NM_003155
STC1	hsa-miR-302c-5p	96.7534	NM_003155
STC1	hsa-miR-183-5p	96.6033	NM_003155
STC1	hsa-miR-615-5p	96.3482	NM_003155
STC1	hsa-miR-499a-5p	96.1266	NM_003155
STC1	hsa-miR-208a-3p	95.8702	NM_003155
STC1	hsa-miR-208b-3p	95.8702	NM_003155
STC1	hsa-miR-144-3p	95.7583	NM_003155
STC1	hsa-miR-3658	94.8829	NM_003155
STC1	hsa-miR-6768-3p	94.2863	NM_003155
STC1	hsa-miR-6529-5p	94.1856	NM_003155
STC1	hsa-miR-6128	94.1252	NM_003155
STC1	hsa-miR-208a-5p	94.0923	NM_003155
STC1	hsa-miR-208b-5p	94.0923	NM_003155
STC1	hsa-miR-3684	93.7229	NM_003155
STC1	hsa-miR-95-5p	93.6398	NM_003155
STC1	hsa-miR-548at-5p	93.6069	NM_003155
STC1	hsa-miR-1915-3p	93.3133	NM_003155
STC1	hsa-miR-6764-5p	92.8379	NM_003155
STC1	hsa-miR-10527-5p	91.7357	NM_003155
STC1	hsa-miR-625-5p	91.5768	NM_003155
STC1	hsa-miR-4425	90.5132	NM_003155
STC1	hsa-miR-606	90.4607	NM_003155
STC1	hsa-miR-7855-5p	90.4084	NM_003155
STC1	hsa-miR-4710	89.3782	NM_003155
STC1	hsa-miR-5197-5p	89.3409	NM_003155
STC1	hsa-miR-5010-5p	89.217	NM_003155
STC1	hsa-miR-3935	88.9128	NM_003155
STC1	hsa-miR-4435	88.6243	NM_003155
STC1	hsa-miR-6852-5p	88.0344	NM_003155
STC1	hsa-miR-7849-3p	87.7461	NM_003155
STC1	hsa-miR-4717-3p	87.3421	NM_003155
STC1	hsa-miR-6894-5p	87.1268	NM_003155
STC1	hsa-miR-3175	87.0574	NM_003155
STC1	hsa-miR-1911-3p	86.6027	NM_003155
STC1	hsa-miR-335-3p	86.5303	NM_003155
STC1	hsa-miR-561-3p	86.2316	NM_003155
STC1	hsa-miR-4525	86.0486	NM_003155
STC1	hsa-miR-4717-5p	85.5639	NM_003155
STC1	hsa-miR-10b-3p	85.2758	NM_003155
STC1	hsa-miR-6840-3p	84.854	NM_003155
STC1	hsa-miR-6513-5p	83.6503	NM_003155
STC1	hsa-miR-935	83.2745	NM_003155
STC1	hsa-miR-6794-5p	82.3288	NM_003155

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Motifs and transcription factors (TFs) regulating STC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STC1	metacluster_26.7	MYNN; MYNN (directAnnotation).
STC1	transfac_pro__M05462	ZNF581 (directAnnotation).
STC1	hdpi__TP73	TP73 (directAnnotation).
STC1	transfac_pro__M06135	ZNF28 (directAnnotation).
STC1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
STC1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
STC1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
STC1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
STC1	jaspar__MA1933.1	SREBF2 (directAnnotation).
STC1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."