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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SS18

Summary for SS18

Gene information	Gene symbol	SS18
	Ensembl ID	ENSG00000141380
	Entrez ID	6760
	Gene name	SS18 subunit of BAF chromatin remodeling complex
	Synonyms	SMARCL1\|SSXT\|SYT
	Gene type	protein_coding
	UniProtAcc	Q15532

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Dataset with differentially expressed gene: SS18

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.25656	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.298	4.16e-27

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Expression of SS18 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SS18

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SS18

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SS18	hsa-miR-6762-3p	99.2984	NM_001007559
SS18	hsa-miR-340-5p	98.8329	NM_001007559
SS18	hsa-miR-206	98.475	NM_001007559
SS18	hsa-miR-1-3p	98.475	NM_001007559
SS18	hsa-miR-371b-5p	98.4193	NM_001007559
SS18	hsa-miR-373-5p	98.4193	NM_001007559
SS18	hsa-miR-616-5p	98.4193	NM_001007559
SS18	hsa-miR-613	97.952	NM_001007559
SS18	hsa-miR-144-3p	97.7685	NM_001007559
SS18	hsa-miR-216a-3p	97.214	NM_001007559
SS18	hsa-miR-128-3p	97.214	NM_001007559
SS18	hsa-miR-137-3p	97.0824	NM_001007559
SS18	hsa-miR-520d-5p	96.8808	NM_001007559
SS18	hsa-miR-524-5p	96.8808	NM_001007559
SS18	hsa-miR-510-3p	96.759	NM_001007559
SS18	hsa-miR-3681-3p	96.5059	NM_001007559
SS18	hsa-miR-372-5p	96.3649	NM_001007559
SS18	hsa-miR-371a-5p	95.4699	NM_001007559
SS18	hsa-miR-197-3p	94.8438	NM_001007559
SS18	hsa-miR-526a-5p	94.2889	NM_001007559
SS18	hsa-miR-518e-5p	94.2889	NM_001007559
SS18	hsa-miR-519b-5p	94.2889	NM_001007559
SS18	hsa-miR-522-5p	94.2889	NM_001007559
SS18	hsa-miR-519a-5p	94.2889	NM_001007559
SS18	hsa-miR-518f-5p	94.2889	NM_001007559
SS18	hsa-miR-519c-5p	94.2889	NM_001007559
SS18	hsa-miR-518d-5p	94.2889	NM_001007559
SS18	hsa-miR-523-5p	94.2889	NM_001007559
SS18	hsa-miR-520c-5p	94.2889	NM_001007559
SS18	hsa-miR-1537-5p	94.19	NM_001007559
SS18	hsa-miR-8054	94.0134	NM_001007559
SS18	hsa-miR-548k	94.0134	NM_001007559
SS18	hsa-miR-548av-5p	94.0134	NM_001007559
SS18	hsa-miR-647	93.6905	NM_001007559
SS18	hsa-miR-3059-5p	93.3047	NM_001007559
SS18	hsa-miR-604	93.1289	NM_001007559
SS18	hsa-miR-1250-3p	92.9067	NM_001007559
SS18	hsa-miR-12136	92.6976	NM_001007559
SS18	hsa-miR-548g-3p	92.6657	NM_001007559
SS18	hsa-miR-6504-3p	92.5945	NM_001007559
SS18	hsa-miR-10399-5p	92.5945	NM_001007559
SS18	hsa-miR-4659b-5p	91.9871	NM_001007559
SS18	hsa-miR-6124	91.9543	NM_001007559
SS18	hsa-miR-4533	91.8412	NM_001007559
SS18	hsa-miR-3613-3p	91.5063	NM_001007559
SS18	hsa-miR-4743-3p	91.0764	NM_001007559
SS18	hsa-miR-889-5p	90.8775	NM_001007559
SS18	hsa-miR-4659a-5p	90.7338	NM_001007559
SS18	hsa-miR-670-5p	90.4111	NM_001007559
SS18	hsa-miR-7114-5p	90.3773	NM_001007559

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Motifs and transcription factors (TFs) regulating SS18

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SS18	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SS18	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
SS18	jaspar__MA1483.2	ELF2 (directAnnotation).
SS18	transfac_pro__M04950	EGR1 (directAnnotation).
SS18	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SS18	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SS18	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SS18	transfac_pro__M00652	NRF1 (directAnnotation).
SS18	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SS18	transfac_pro__M04866	HDAC2 (directAnnotation).
SS18	jaspar__MA1122.1	TFDP1 (directAnnotation).
SS18	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
SS18	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SS18	metacluster_135.11	NR2C2 (directAnnotation).
SS18	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SS18	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SS18	metacluster_7.13	ZFX (directAnnotation).
SS18	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SS18	cisbp__M00968	MTF2 (directAnnotation).
SS18	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SS18	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SS18	cisbp__M00341	PAX6 (directAnnotation).
SS18	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SS18	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SS18	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SS18	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SS18	cisbp__M00788	ZFY (inferredBy_Orthology).
SS18	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SS18	metacluster_175.1	ZNF283 (directAnnotation).
SS18	hdpi__ZNF304	ZNF304 (directAnnotation).
SS18	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SS18	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SS18	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SS18	transfac_pro__M01199	TRIM28 (directAnnotation).
SS18	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SS18	metacluster_151.2	ZNF23 (directAnnotation).
SS18	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SS18	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SS18	transfac_pro__M03806	ZBTB7C (directAnnotation).
SS18	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."