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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SERINC5

Summary for SERINC5

Gene information	Gene symbol	SERINC5
	Ensembl ID	ENSG00000164300
	Entrez ID	256987
	Gene name	serine incorporator 5
	Synonyms	C5orf12\|TPO1
	Gene type	protein_coding
	UniProtAcc	Q86VE9

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Dataset with differentially expressed gene: SERINC5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.443619	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.301005	1.64e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.376053	1.41e-40

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Expression of SERINC5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SERINC5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SERINC5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SERINC5	hsa-miR-298	98.956	NM_001174072
SERINC5	hsa-miR-513c-3p	97.1139	NM_001174072
SERINC5	hsa-miR-513a-3p	97.1139	NM_001174072
SERINC5	hsa-miR-3160-5p	96.6958	NM_001174072
SERINC5	hsa-miR-146b-3p	96.1686	NM_001174072
SERINC5	hsa-miR-3606-3p	95.222	NM_001174072
SERINC5	hsa-miR-4797-5p	94.1129	NM_001174072
SERINC5	hsa-miR-6768-3p	94.0291	NM_001174072
SERINC5	hsa-miR-23b-3p	93.8326	NM_001174072
SERINC5	hsa-miR-23c	93.8326	NM_001174072
SERINC5	hsa-miR-23a-3p	93.8326	NM_001174072
SERINC5	hsa-miR-5582-3p	93.4208	NM_001174072
SERINC5	hsa-miR-5195-3p	93.293	NM_001174072
SERINC5	hsa-miR-548av-5p	93.2246	NM_001174072
SERINC5	hsa-miR-548k	93.2246	NM_001174072
SERINC5	hsa-miR-8054	93.2246	NM_001174072
SERINC5	hsa-miR-3143	93.0864	NM_001174072
SERINC5	hsa-miR-21-3p	92.9893	NM_001174072
SERINC5	hsa-miR-122b-3p	92.9893	NM_001174072
SERINC5	hsa-miR-182-5p	92.7806	NM_001174072
SERINC5	hsa-miR-431-5p	92.3213	NM_001174071
SERINC5	hsa-miR-339-5p	92.2932	NM_001174072
SERINC5	hsa-miR-600	92.2364	NM_001174071
SERINC5	hsa-miR-96-5p	92.0904	NM_001174072
SERINC5	hsa-miR-145-5p	91.8587	NM_001174072
SERINC5	hsa-miR-520d-5p	91.563	NM_001174072
SERINC5	hsa-miR-524-5p	91.563	NM_001174072
SERINC5	hsa-miR-302c-5p	91.5346	NM_001174072
SERINC5	hsa-miR-4470	91.2622	NM_001174072
SERINC5	hsa-miR-4328	91.1687	NM_001174072
SERINC5	hsa-miR-218-5p	91.023	NM_001174072
SERINC5	hsa-miR-6881-3p	90.0002	NM_001174072
SERINC5	hsa-miR-12133	89.4301	NM_001174072
SERINC5	hsa-miR-1271-5p	89.4301	NM_001174072
SERINC5	hsa-miR-6508-5p	89.3929	NM_001174072
SERINC5	hsa-miR-4742-5p	89.2682	NM_001174071
SERINC5	hsa-miR-518a-5p	89.0696	NM_001174072
SERINC5	hsa-miR-527	89.0696	NM_001174072
SERINC5	hsa-miR-8067	88.4234	NM_001174072
SERINC5	hsa-miR-548ar-3p	88.3341	NM_001174072
SERINC5	hsa-miR-651-3p	88.3204	NM_001174072
SERINC5	hsa-miR-590-3p	87.4903	NM_001174072
SERINC5	hsa-miR-548az-3p	87.3691	NM_001174072
SERINC5	hsa-miR-559	87.1524	NM_001174072
SERINC5	hsa-miR-302d-5p	86.989	NM_001174072
SERINC5	hsa-miR-302b-5p	86.989	NM_001174072
SERINC5	hsa-miR-548p	86.3953	NM_001174072
SERINC5	hsa-miR-548d-5p	86.3906	NM_001174072
SERINC5	hsa-miR-548o-5p	86.3906	NM_001174072
SERINC5	hsa-miR-548i	86.3906	NM_001174072

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Motifs and transcription factors (TFs) regulating SERINC5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SERINC5	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SERINC5	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SERINC5	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SERINC5	transfac_public__M00024	E2F1 (directAnnotation).
SERINC5	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SERINC5	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SERINC5	jaspar__MA1933.1	SREBF2 (directAnnotation).
SERINC5	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
SERINC5	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SERINC5	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SERINC5	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
SERINC5	transfac_pro__M01298	MECP2 (directAnnotation).
SERINC5	metacluster_135.11	NR2C2 (directAnnotation).
SERINC5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SERINC5	cisbp__M00968	MTF2 (directAnnotation).
SERINC5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SERINC5	metacluster_198.3	ZFP64 (directAnnotation).
SERINC5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SERINC5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SERINC5	metacluster_175.1	ZNF283 (directAnnotation).
SERINC5	hdpi__ZNF304	ZNF304 (directAnnotation).
SERINC5	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SERINC5	transfac_pro__M03806	ZBTB7C (directAnnotation).
SERINC5	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
SERINC5	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SERINC5	transfac_pro__M07317	CTBP1 (directAnnotation).
SERINC5	transfac_pro__M12697	ZNF142 (directAnnotation).
SERINC5	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SERINC5	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SERINC5	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SERINC5	jaspar__MA1650.1	ZBTB14 (directAnnotation).
SERINC5	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
SERINC5	metacluster_45.4	E2F2 (directAnnotation).
SERINC5	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
SERINC5	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
SERINC5	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
SERINC5	transfac_pro__M09837	ZNF449 (directAnnotation).
SERINC5	hdpi__GTF3C2	GTF3C2 (directAnnotation).
SERINC5	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
SERINC5	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SERINC5	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
SERINC5	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."