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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RTN1

Summary for RTN1

Gene information	Gene symbol	RTN1
	Ensembl ID	ENSG00000139970
	Entrez ID	6252
	Gene name	reticulon 1
	Synonyms	NSP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RTN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	6.01739	1.49e-26
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-1.05195	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.570172	2.22e-20
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.31385	7.60e-06

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Expression of RTN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RTN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RTN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RTN1	hsa-miR-4729	98.8485	NM_021136
RTN1	hsa-miR-302e	97.539	NM_021136
RTN1	hsa-miR-6867-5p	96.919	NM_021136
RTN1	hsa-miR-519b-3p	96.6111	NM_021136
RTN1	hsa-miR-519a-3p	96.6111	NM_021136
RTN1	hsa-miR-519c-3p	96.6111	NM_021136
RTN1	hsa-miR-6516-5p	95.6303	NM_206852
RTN1	hsa-miR-302d-3p	95.3838	NM_021136
RTN1	hsa-miR-302a-3p	95.3838	NM_021136
RTN1	hsa-miR-302b-3p	95.3838	NM_021136
RTN1	hsa-miR-302c-3p	95.3838	NM_021136
RTN1	hsa-miR-802	94.9687	NM_021136
RTN1	hsa-miR-6818-3p	94.4935	NM_021136
RTN1	hsa-miR-3678-3p	94.2199	NM_021136
RTN1	hsa-miR-372-3p	92.8272	NM_021136
RTN1	hsa-miR-520c-3p	92.8272	NM_021136
RTN1	hsa-miR-520b-3p	92.8272	NM_021136
RTN1	hsa-miR-520a-3p	92.8272	NM_021136
RTN1	hsa-miR-520e-3p	92.8272	NM_021136
RTN1	hsa-miR-520d-3p	92.8272	NM_021136
RTN1	hsa-miR-373-3p	92.8272	NM_021136
RTN1	hsa-miR-301a-3p	92.4667	NM_021136
RTN1	hsa-miR-3666	92.4667	NM_021136
RTN1	hsa-miR-454-3p	92.4667	NM_021136
RTN1	hsa-miR-4295	92.4667	NM_021136
RTN1	hsa-miR-130b-3p	92.4667	NM_021136
RTN1	hsa-miR-301b-3p	92.4667	NM_021136
RTN1	hsa-miR-130a-3p	92.4667	NM_021136
RTN1	hsa-miR-497-3p	91.8296	NM_021136
RTN1	hsa-miR-2054	90.8454	NM_206852
RTN1	hsa-miR-12123	90.6664	NM_206852
RTN1	hsa-let-7b-3p	90.628	NM_021136
RTN1	hsa-miR-98-3p	90.628	NM_021136
RTN1	hsa-let-7f-1-3p	90.628	NM_021136
RTN1	hsa-let-7a-3p	90.628	NM_021136
RTN1	hsa-miR-4666a-5p	90.1283	NM_021136
RTN1	hsa-miR-4325	89.8267	NM_021136
RTN1	hsa-miR-664a-3p	89.1239	NM_206852
RTN1	hsa-miR-8068	89.0524	NM_206852
RTN1	hsa-miR-944	89.0269	NM_206852
RTN1	hsa-miR-3143	88.6266	NM_021136
RTN1	hsa-miR-19b-3p	87.5895	NM_021136
RTN1	hsa-miR-19a-3p	87.5895	NM_021136
RTN1	hsa-miR-3914	87.2632	NM_021136
RTN1	hsa-miR-6814-5p	86.7682	NM_206852
RTN1	hsa-miR-4797-5p	85.8642	NM_021136
RTN1	hsa-miR-374c-5p	85.743	NM_206852
RTN1	hsa-miR-655-3p	85.743	NM_206852
RTN1	hsa-miR-5697	85.3807	NM_206852
RTN1	hsa-miR-5696	84.64	NM_206852

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Motifs and transcription factors (TFs) regulating RTN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RTN1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RTN1	jaspar__MA1483.2	ELF2 (directAnnotation).
RTN1	transfac_pro__M05481	ZNF202 (directAnnotation).
RTN1	transfac_pro__M05522	ZNF341 (directAnnotation).
RTN1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
RTN1	metacluster_70.16	POU5F1; POU5F1 (directAnnotation).
RTN1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
RTN1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
RTN1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
RTN1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RTN1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RTN1	transfac_pro__M04617	ZBTB7A (directAnnotation).
RTN1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RTN1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RTN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RTN1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RTN1	transfac_pro__M07387	ZBTB7A (directAnnotation).
RTN1	transfac_pro__M07436	WT1 (directAnnotation).
RTN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RTN1	transfac_pro__M00716	ZBTB14 (directAnnotation).
RTN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RTN1	hdpi__HIP2	UBE2K (directAnnotation).
RTN1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RTN1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RTN1	transfac_pro__M04893	TAF1 (directAnnotation).
RTN1	transfac_pro__M03876	ZBTB33 (directAnnotation).
RTN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RTN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RTN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RTN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RTN1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
RTN1	transfac_pro__M06347	ZNF782 (directAnnotation).
RTN1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
RTN1	hdpi__GTF3C2	GTF3C2 (directAnnotation).
RTN1	transfac_pro__M03806	ZBTB7C (directAnnotation).
RTN1	transfac_pro__M05993	ZNF711 (directAnnotation).
RTN1	hdpi__FEZF2	FEZF2 (directAnnotation).
RTN1	metacluster_198.3	ZFP64 (directAnnotation).
RTN1	hdpi__NRL	NRL (directAnnotation).
RTN1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RTN1	tfdimers__MD00483	ZBTB14 (directAnnotation).
RTN1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
RTN1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."