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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCOR1

Summary for RCOR1

Gene information	Gene symbol	RCOR1
	Ensembl ID	ENSG00000089902
	Entrez ID	23186
	Gene name	REST corepressor 1
	Synonyms	COREST\|KIAA0071\|RCOR
	Gene type	protein_coding
	UniProtAcc	Q9UKL0

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Dataset with differentially expressed gene: RCOR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.25596	4.70e-04
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.386677	2.14e-39

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Expression of RCOR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCOR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCOR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCOR1	hsa-miR-3529-3p	99.7912	NM_015156
RCOR1	hsa-miR-196a-1-3p	98.3553	NM_015156
RCOR1	hsa-miR-6734-3p	97.5168	NM_015156
RCOR1	hsa-miR-6069	97.4481	NM_015156
RCOR1	hsa-miR-3692-3p	97.4149	NM_015156
RCOR1	hsa-miR-22-3p	96.2344	NM_015156
RCOR1	hsa-miR-5011-5p	95.9857	NM_015156
RCOR1	hsa-miR-3714	95.7173	NM_015156
RCOR1	hsa-miR-1910-3p	94.9567	NM_015156
RCOR1	hsa-miR-6511a-5p	94.9567	NM_015156
RCOR1	hsa-miR-1297	94.5576	NM_015156
RCOR1	hsa-miR-656-5p	94.4989	NM_015156
RCOR1	hsa-miR-5700	94.2743	NM_015156
RCOR1	hsa-miR-3158-5p	93.851	NM_015156
RCOR1	hsa-miR-4719	93.4838	NM_015156
RCOR1	hsa-miR-4282	93.3441	NM_015156
RCOR1	hsa-miR-26b-5p	93.343	NM_015156
RCOR1	hsa-miR-26a-5p	93.343	NM_015156
RCOR1	hsa-miR-448	92.5095	NM_015156
RCOR1	hsa-miR-532-5p	92.3457	NM_015156
RCOR1	hsa-miR-4465	91.7433	NM_015156
RCOR1	hsa-miR-153-3p	90.7659	NM_015156
RCOR1	hsa-miR-545-3p	89.2375	NM_015156
RCOR1	hsa-miR-548ah-5p	89.1772	NM_015156
RCOR1	hsa-miR-3609	89.1772	NM_015156
RCOR1	hsa-miR-218-5p	89.0805	NM_015156
RCOR1	hsa-miR-5681b	88.9866	NM_015156
RCOR1	hsa-miR-4694-3p	88.9769	NM_015156
RCOR1	hsa-miR-513b-5p	88.4335	NM_015156
RCOR1	hsa-miR-802	88.2481	NM_015156
RCOR1	hsa-miR-6811-5p	87.7173	NM_015156
RCOR1	hsa-miR-197-3p	87.6629	NM_015156
RCOR1	hsa-miR-4753-5p	87.4309	NM_015156
RCOR1	hsa-miR-6511b-5p	87.259	NM_015156
RCOR1	hsa-miR-6501-5p	86.8021	NM_015156
RCOR1	hsa-miR-506-3p	86.0966	NM_015156
RCOR1	hsa-miR-124-3p	86.0966	NM_015156
RCOR1	hsa-miR-641	85.5283	NM_015156
RCOR1	hsa-miR-3617-5p	85.5283	NM_015156
RCOR1	hsa-miR-12119	85.1681	NM_015156
RCOR1	hsa-miR-190a-5p	85.0451	NM_015156
RCOR1	hsa-miR-190b-5p	85.0451	NM_015156
RCOR1	hsa-miR-4422	84.7028	NM_015156
RCOR1	hsa-miR-5581-5p	84.6702	NM_015156
RCOR1	hsa-miR-4297	84.6702	NM_015156
RCOR1	hsa-miR-4515	84.3126	NM_015156
RCOR1	hsa-miR-6835-3p	84.274	NM_015156
RCOR1	hsa-miR-4728-3p	84.2537	NM_015156
RCOR1	hsa-miR-558	83.9477	NM_015156
RCOR1	hsa-miR-605-3p	83.457	NM_015156

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Motifs and transcription factors (TFs) regulating RCOR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCOR1	metacluster_135.11	NR2C2 (directAnnotation).
RCOR1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RCOR1	tfdimers__MD00038	TFAP2C (directAnnotation).
RCOR1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RCOR1	metacluster_7.13	ZFX (directAnnotation).
RCOR1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RCOR1	cisbp__M00968	MTF2 (directAnnotation).
RCOR1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RCOR1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RCOR1	cisbp__M00341	PAX6 (directAnnotation).
RCOR1	metacluster_198.3	ZFP64 (directAnnotation).
RCOR1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RCOR1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RCOR1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RCOR1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RCOR1	cisbp__M00788	ZFY (inferredBy_Orthology).
RCOR1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RCOR1	metacluster_175.1	ZNF283 (directAnnotation).
RCOR1	hdpi__ZNF304	ZNF304 (directAnnotation).
RCOR1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RCOR1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RCOR1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RCOR1	transfac_pro__M01199	TRIM28 (directAnnotation).
RCOR1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RCOR1	metacluster_151.2	ZNF23 (directAnnotation).
RCOR1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RCOR1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RCOR1	transfac_pro__M03806	ZBTB7C (directAnnotation).
RCOR1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RCOR1	hdpi__GTF3C2	GTF3C2 (directAnnotation).
RCOR1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RCOR1	hdpi__NRL	NRL (directAnnotation).
RCOR1	tfdimers__MD00483	ZBTB14 (directAnnotation).
RCOR1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."