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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RCAN2

Summary for RCAN2

Gene information	Gene symbol	RCAN2
	Ensembl ID	ENSG00000172348
	Entrez ID	10231
	Gene name	regulator of calcineurin 2
	Synonyms	DSCR1L1\|ZAKI-4
	Gene type	protein_coding
	UniProtAcc	Q14206

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Dataset with differentially expressed gene: RCAN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	5.43428	9.36e-04
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.486685	0.00e+00

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Expression of RCAN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RCAN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCAN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RCAN2	hsa-miR-6756-3p	98.9396	NM_001251974
RCAN2	hsa-miR-3127-3p	98.9396	NM_001251974
RCAN2	hsa-miR-4506	98.7062	NM_001251974
RCAN2	hsa-miR-583	95.9685	NM_001251973
RCAN2	hsa-miR-1250-3p	94.8548	NM_001251974
RCAN2	hsa-miR-4649-3p	94.1671	NM_001251973
RCAN2	hsa-miR-4311	94.0621	NM_001251973
RCAN2	hsa-miR-27b-3p	93.2769	NM_001251974
RCAN2	hsa-miR-27a-3p	93.2769	NM_001251974
RCAN2	hsa-miR-9985	93.2769	NM_001251974
RCAN2	hsa-miR-488-5p	93.1249	NM_001251974
RCAN2	hsa-miR-4799-5p	92.6796	NM_001251974
RCAN2	hsa-miR-1227-5p	92.6755	NM_001251973
RCAN2	hsa-miR-6716-5p	91.6405	NM_001251974
RCAN2	hsa-miR-1276	90.8501	NM_001251973
RCAN2	hsa-miR-548an	90.6819	NM_001251973
RCAN2	hsa-miR-548c-3p	90.4834	NM_001251974
RCAN2	hsa-miR-646	89.8148	NM_001251973
RCAN2	hsa-miR-197-3p	89.5129	NM_001251974
RCAN2	hsa-miR-4772-5p	88.7493	NM_001251974
RCAN2	hsa-miR-6767-3p	88.5896	NM_001251973
RCAN2	hsa-miR-138-5p	88.4684	NM_001251973
RCAN2	hsa-miR-6840-3p	88.2715	NM_001251973
RCAN2	hsa-miR-196a-1-3p	88.2499	NM_001251973
RCAN2	hsa-miR-2054	88.0437	NM_001251974
RCAN2	hsa-miR-7114-3p	87.9295	NM_001251974
RCAN2	hsa-miR-384	87.8326	NM_001251973
RCAN2	hsa-miR-3188	87.6406	NM_001251973
RCAN2	hsa-miR-4711-3p	87.6056	NM_001251974
RCAN2	hsa-miR-6796-3p	87.2647	NM_001251974
RCAN2	hsa-miR-4677-3p	87.1432	NM_001251974
RCAN2	hsa-miR-4260	87.0442	NM_001251973
RCAN2	hsa-miR-129-1-3p	86.6737	NM_001251973
RCAN2	hsa-miR-129-2-3p	86.6737	NM_001251973
RCAN2	hsa-miR-8055	86.572	NM_001251973
RCAN2	hsa-miR-1912-3p	86.1041	NM_001251973
RCAN2	hsa-miR-520d-5p	86.045	NM_001251973
RCAN2	hsa-miR-524-5p	86.045	NM_001251973
RCAN2	hsa-miR-3680-3p	85.6011	NM_001251974
RCAN2	hsa-miR-4786-5p	85.1936	NM_001251973
RCAN2	hsa-miR-3121-3p	84.8465	NM_001251973
RCAN2	hsa-miR-2467-3p	84.0334	NM_001251974
RCAN2	hsa-miR-1180-5p	84.0095	NM_001251974
RCAN2	hsa-miR-4487	83.8062	NM_001251974
RCAN2	hsa-miR-1295b-5p	83.6228	NM_001251973
RCAN2	hsa-miR-12119	83.2646	NM_001251974
RCAN2	hsa-miR-6845-5p	82.9236	NM_001251973
RCAN2	hsa-miR-6762-5p	82.9236	NM_001251973
RCAN2	hsa-miR-4700-5p	82.8606	NM_001251973
RCAN2	hsa-miR-216a-3p	82.805	NM_001251974

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Motifs and transcription factors (TFs) regulating RCAN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RCAN2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RCAN2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RCAN2	transfac_pro__M07397	ZNF148 (directAnnotation).
RCAN2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
RCAN2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
RCAN2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RCAN2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
RCAN2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RCAN2	metacluster_7.13	ZFX (directAnnotation).
RCAN2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RCAN2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
RCAN2	transfac_pro__M01175	ZBTB7B (directAnnotation).
RCAN2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RCAN2	tfdimers__MD00151	CHURC1 (directAnnotation).
RCAN2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RCAN2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RCAN2	transfac_pro__M01303	SP1 (directAnnotation).
RCAN2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RCAN2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RCAN2	transfac_pro__M02090	E2F4 (directAnnotation).
RCAN2	transfac_pro__M01714	KLF15 (directAnnotation).
RCAN2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
RCAN2	transfac_pro__M02089	E2F3 (directAnnotation).
RCAN2	transfac_pro__M12604	ZNF444 (directAnnotation).
RCAN2	metacluster_3.14	WT1; WT1 (directAnnotation).
RCAN2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
RCAN2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RCAN2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
RCAN2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RCAN2	cisbp__M07938	E2F1 (directAnnotation).
RCAN2	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
RCAN2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RCAN2	transfac_pro__M07436	WT1 (directAnnotation).
RCAN2	transfac_pro__M02281	SP1 (directAnnotation).
RCAN2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RCAN2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RCAN2	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
RCAN2	transfac_pro__M02898	SMAD3 (directAnnotation).
RCAN2	transfac_public__M00491	PATZ1 (directAnnotation).
RCAN2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RCAN2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
RCAN2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RCAN2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RCAN2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RCAN2	transfac_pro__M04617	ZBTB7A (directAnnotation).
RCAN2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RCAN2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RCAN2	transfac_pro__M07387	ZBTB7A (directAnnotation).
RCAN2	transfac_pro__M00716	ZBTB14 (directAnnotation).
RCAN2	hdpi__HIP2	UBE2K (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."