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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB11FIP1

Summary for RAB11FIP1

Gene information	Gene symbol	RAB11FIP1
	Ensembl ID	ENSG00000156675
	Entrez ID	80223
	Gene name	RAB11 family interacting protein 1
	Synonyms	FLJ22524\|FLJ22622\|Rab11-FIP1\|RCP
	Gene type	protein_coding
	UniProtAcc	Q6WKZ4

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Dataset with differentially expressed gene: RAB11FIP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.28782	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.838866	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.286902	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.281544	2.12e-04
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.311173	5.29e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.329662	1.09e-11
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.288689	3.14e-09
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.482474	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.33041	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.266811	2.03e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.53969	1.20e-32
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.259059	3.35e-35
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.950187	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.923217	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.682851	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.775193	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.489136	0.00e+00

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Expression of RAB11FIP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB11FIP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB11FIP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB11FIP1	hsa-miR-205-5p	99.3702	NM_025151
RAB11FIP1	hsa-miR-3163	98.5367	NM_025151
RAB11FIP1	hsa-miR-186-3p	97.2436	NM_025151
RAB11FIP1	hsa-miR-4251	97.1626	NM_025151
RAB11FIP1	hsa-miR-548an	92.9985	NM_025151
RAB11FIP1	hsa-miR-488-3p	92.4457	NM_001002814
RAB11FIP1	hsa-miR-20a-5p	92.3756	NM_025151
RAB11FIP1	hsa-miR-106b-5p	92.3756	NM_025151
RAB11FIP1	hsa-miR-5693	91.9982	NM_001002814
RAB11FIP1	hsa-miR-7856-5p	91.6011	NM_001002814
RAB11FIP1	hsa-miR-20b-5p	90.5252	NM_025151
RAB11FIP1	hsa-miR-17-5p	90.5252	NM_025151
RAB11FIP1	hsa-miR-93-5p	90.5252	NM_025151
RAB11FIP1	hsa-miR-519d-3p	90.5252	NM_025151
RAB11FIP1	hsa-miR-526b-3p	90.5203	NM_025151
RAB11FIP1	hsa-miR-106a-5p	90.5203	NM_025151
RAB11FIP1	hsa-miR-6165	89.1464	NM_025151
RAB11FIP1	hsa-miR-302e	89.1309	NM_025151
RAB11FIP1	hsa-miR-506-3p	89.0441	NM_025151
RAB11FIP1	hsa-miR-124-3p	89.0441	NM_025151
RAB11FIP1	hsa-miR-4797-3p	88.6416	NM_001002814
RAB11FIP1	hsa-miR-3115	88.6216	NM_001002814
RAB11FIP1	hsa-miR-541-3p	88.5792	NM_001002814
RAB11FIP1	hsa-miR-654-5p	88.5792	NM_001002814
RAB11FIP1	hsa-miR-4770	87.0829	NM_025151
RAB11FIP1	hsa-miR-143-3p	87.0829	NM_025151
RAB11FIP1	hsa-miR-12124	86.0394	NM_025151
RAB11FIP1	hsa-miR-545-5p	85.21	NM_025151
RAB11FIP1	hsa-miR-302a-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-302b-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-372-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-302c-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-520b-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-520d-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-520c-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-520a-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-520e-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-373-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-302d-3p	85.198	NM_025151
RAB11FIP1	hsa-miR-3613-3p	84.8526	NM_001002814
RAB11FIP1	hsa-miR-122b-5p	84.7891	NM_025151
RAB11FIP1	hsa-miR-9985	84.787	NM_025151
RAB11FIP1	hsa-miR-27a-3p	84.787	NM_025151
RAB11FIP1	hsa-miR-27b-3p	84.787	NM_025151
RAB11FIP1	hsa-miR-6130	84.6035	NM_001002814
RAB11FIP1	hsa-miR-6129	84.6035	NM_001002814
RAB11FIP1	hsa-miR-6127	84.6035	NM_001002814
RAB11FIP1	hsa-miR-4510	84.6035	NM_001002814
RAB11FIP1	hsa-miR-6133	84.6035	NM_001002814
RAB11FIP1	hsa-miR-8065	83.5848	NM_001002814

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Motifs and transcription factors (TFs) regulating RAB11FIP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB11FIP1	jaspar__MA1483.2	ELF2 (directAnnotation).
RAB11FIP1	transfac_pro__M06827	ZBTB11 (directAnnotation).
RAB11FIP1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
RAB11FIP1	metacluster_33.5	MTF1 (inferredBy_Orthology).
RAB11FIP1	transfac_pro__M06564	ZNF578 (directAnnotation).
RAB11FIP1	transfac_pro__M05670	ZNF37A (directAnnotation).
RAB11FIP1	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
RAB11FIP1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
RAB11FIP1	cisbp__M00341	PAX6 (directAnnotation).
RAB11FIP1	tfdimers__MD00488	ELF1; HDX (directAnnotation).
RAB11FIP1	transfac_pro__M12556	ETV4 (directAnnotation).
RAB11FIP1	taipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAP	FLI1; MAX (directAnnotation).
RAB11FIP1	metacluster_175.1	ZNF283 (directAnnotation).
RAB11FIP1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB11FIP1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
RAB11FIP1	transfac_pro__M06035	ZNF749 (directAnnotation).
RAB11FIP1	tfdimers__MD00097	GABPA; PAX4 (directAnnotation).
RAB11FIP1	transfac_pro__M06353	ZNF782 (directAnnotation).
RAB11FIP1	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
RAB11FIP1	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
RAB11FIP1	transfac_pro__M06257	ZNF616 (directAnnotation).
RAB11FIP1	jaspar__MA1955.1	FOXO1 (directAnnotation).
RAB11FIP1	tfdimers__MD00204	GABPA; NKX2-1 (directAnnotation).
RAB11FIP1	transfac_pro__M06085	ZNF26 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."