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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: PBX1

Summary for PBX1

Gene information	Gene symbol	PBX1
	Ensembl ID	ENSG00000185630
	Entrez ID	5087
	Gene name	PBX homeobox 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P40424

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Dataset with differentially expressed gene: PBX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.429441	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.329084	2.02e-13

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Expression of PBX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PBX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PBX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PBX1	hsa-miR-4427	99.3393	NM_001204963
PBX1	hsa-miR-450b-5p	99.2995	NM_002585
PBX1	hsa-miR-3059-5p	98.6665	NM_001204961
PBX1	hsa-miR-9983-3p	98.6383	NM_001204961
PBX1	hsa-miR-129-5p	98.1531	NM_001204961
PBX1	hsa-miR-6727-3p	97.9685	NM_001204961
PBX1	hsa-miR-4722-3p	96.6956	NM_001204961
PBX1	hsa-miR-6757-5p	96.0765	NM_001204963
PBX1	hsa-miR-6077	95.5868	NM_002585
PBX1	hsa-miR-3925-5p	95.2103	NM_001204961
PBX1	hsa-miR-196a-5p	95.1528	NM_001204961
PBX1	hsa-miR-196b-5p	95.1528	NM_001204961
PBX1	hsa-miR-4500	95.0205	NM_001204961
PBX1	hsa-miR-5197-3p	94.4354	NM_002585
PBX1	hsa-miR-548aa	94.2008	NM_001204961
PBX1	hsa-miR-548ap-3p	94.2008	NM_001204961
PBX1	hsa-miR-548t-3p	94.2008	NM_001204961
PBX1	hsa-miR-561-3p	94.1886	NM_001204963
PBX1	hsa-miR-12122	93.6115	NM_001204963
PBX1	hsa-miR-6811-3p	93.3537	NM_001204961
PBX1	hsa-miR-6514-3p	93.0931	NM_001204961
PBX1	hsa-miR-1295b-5p	92.5278	NM_001204961
PBX1	hsa-miR-770-5p	92.5125	NM_001204961
PBX1	hsa-miR-4712-5p	92.5125	NM_001204961
PBX1	hsa-miR-9500	92.3072	NM_002585
PBX1	hsa-miR-1912-3p	92.2311	NM_001204961
PBX1	hsa-miR-4518	91.9889	NM_001204963
PBX1	hsa-miR-1266-5p	91.9889	NM_001204963
PBX1	hsa-miR-320c	91.9425	NM_001204963
PBX1	hsa-miR-320a-3p	91.9425	NM_001204963
PBX1	hsa-miR-4429	91.9425	NM_001204963
PBX1	hsa-miR-320d	91.9425	NM_001204963
PBX1	hsa-miR-320b	91.9425	NM_001204963
PBX1	hsa-miR-153-5p	91.4937	NM_001204963
PBX1	hsa-miR-206	91.0815	NM_002585
PBX1	hsa-miR-1-3p	91.0815	NM_002585
PBX1	hsa-miR-324-5p	91.0586	NM_002585
PBX1	hsa-let-7b-5p	91.0036	NM_001204961
PBX1	hsa-let-7a-5p	91.0036	NM_001204961
PBX1	hsa-miR-98-5p	91.0036	NM_001204961
PBX1	hsa-let-7i-5p	91.0036	NM_001204961
PBX1	hsa-let-7c-5p	91.0036	NM_001204961
PBX1	hsa-let-7f-5p	91.0036	NM_001204961
PBX1	hsa-let-7g-5p	91.0036	NM_001204961
PBX1	hsa-let-7e-5p	91.0036	NM_001204961
PBX1	hsa-miR-4458	90.9336	NM_001204961
PBX1	hsa-let-7d-5p	90.9336	NM_001204961
PBX1	hsa-miR-3074-5p	90.281	NM_001204961
PBX1	hsa-miR-4738-3p	90.2242	NM_002585
PBX1	hsa-miR-3180-5p	89.8632	NM_001204963

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Motifs and transcription factors (TFs) regulating PBX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
PBX1	metacluster_174.2	up	Malignant cells	GSE163836	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."