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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAFAH1B2

Summary for PAFAH1B2

Gene information	Gene symbol	PAFAH1B2
	Ensembl ID	ENSG00000168092
	Entrez ID	5049
	Gene name	platelet activating factor acetylhydrolase 1b catalytic subunit 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P68402

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Dataset with differentially expressed gene: PAFAH1B2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.270043	8.90e-42
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.29551	1.26e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.448875	1.68e-44

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Expression of PAFAH1B2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAFAH1B2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAFAH1B2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAFAH1B2	hsa-miR-33b-3p	97.9174	NM_002572
PAFAH1B2	hsa-miR-515-3p	97.9174	NM_002572
PAFAH1B2	hsa-miR-519e-3p	97.9174	NM_002572
PAFAH1B2	hsa-miR-3163	97.8801	NM_002572
PAFAH1B2	hsa-miR-3127-3p	97.2497	NM_002572
PAFAH1B2	hsa-miR-6756-3p	97.2497	NM_002572
PAFAH1B2	hsa-miR-29b-1-5p	96.8448	NM_002572
PAFAH1B2	hsa-miR-195-5p	96.1096	NM_002572
PAFAH1B2	hsa-miR-16-5p	96.1096	NM_002572
PAFAH1B2	hsa-miR-4789-5p	95.8885	NM_002572
PAFAH1B2	hsa-miR-200a-3p	95.7393	NM_002572
PAFAH1B2	hsa-miR-141-3p	95.7393	NM_002572
PAFAH1B2	hsa-miR-15b-5p	95.2893	NM_002572
PAFAH1B2	hsa-miR-15a-5p	95.2893	NM_002572
PAFAH1B2	hsa-miR-4262	95.0973	NM_002572
PAFAH1B2	hsa-miR-4729	95.0374	NM_002572
PAFAH1B2	hsa-miR-3179	94.7934	NM_002572
PAFAH1B2	hsa-miR-107	94.3403	NM_002572
PAFAH1B2	hsa-miR-103a-3p	94.3403	NM_002572
PAFAH1B2	hsa-miR-12136	94.0006	NM_002572
PAFAH1B2	hsa-miR-95-5p	93.8775	NM_002572
PAFAH1B2	hsa-miR-6124	93.8256	NM_002572
PAFAH1B2	hsa-miR-6838-5p	92.6518	NM_002572
PAFAH1B2	hsa-miR-3128	91.0422	NM_002572
PAFAH1B2	hsa-miR-181c-5p	90.6597	NM_002572
PAFAH1B2	hsa-miR-181d-5p	90.6597	NM_002572
PAFAH1B2	hsa-miR-181a-5p	90.6597	NM_002572
PAFAH1B2	hsa-miR-181b-5p	90.6597	NM_002572
PAFAH1B2	hsa-miR-424-5p	90.1426	NM_002572
PAFAH1B2	hsa-miR-497-5p	90.1426	NM_002572
PAFAH1B2	hsa-miR-1185-2-3p	90.0547	NM_001184746
PAFAH1B2	hsa-let-7f-2-3p	90.0547	NM_001184746
PAFAH1B2	hsa-miR-1185-1-3p	90.0547	NM_001184746
PAFAH1B2	hsa-miR-1207-3p	89.4628	NM_001184748
PAFAH1B2	hsa-miR-643	88.0105	NM_001184748
PAFAH1B2	hsa-miR-944	87.7622	NM_002572
PAFAH1B2	hsa-miR-4700-3p	87.443	NM_002572
PAFAH1B2	hsa-miR-12131	87.1668	NM_001184747
PAFAH1B2	hsa-miR-5585-5p	86.8381	NM_002572
PAFAH1B2	hsa-miR-5582-3p	86.7409	NM_002572
PAFAH1B2	hsa-miR-545-3p	86.2046	NM_001184748
PAFAH1B2	hsa-miR-1279	85.5698	NM_002572
PAFAH1B2	hsa-miR-31-3p	84.9344	NM_001184748
PAFAH1B2	hsa-miR-607	84.0285	NM_002572
PAFAH1B2	hsa-miR-4531	83.6976	NM_001184747
PAFAH1B2	hsa-miR-4659a-3p	83.2557	NM_002572
PAFAH1B2	hsa-miR-4659b-3p	83.2557	NM_002572
PAFAH1B2	hsa-miR-570-3p	82.7971	NM_002572
PAFAH1B2	hsa-miR-4279	82.4322	NM_002572
PAFAH1B2	hsa-miR-212-5p	81.7129	NM_002572

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Motifs and transcription factors (TFs) regulating PAFAH1B2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAFAH1B2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PAFAH1B2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
PAFAH1B2	jaspar__MA1483.2	ELF2 (directAnnotation).
PAFAH1B2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PAFAH1B2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PAFAH1B2	hdpi__ETV4	ETV4 (directAnnotation).
PAFAH1B2	jaspar__MA0079.5	SP1 (directAnnotation).
PAFAH1B2	transfac_pro__M04826	EP300 (directAnnotation).
PAFAH1B2	metacluster_135.11	NR2C2 (directAnnotation).
PAFAH1B2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PAFAH1B2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PAFAH1B2	cisbp__M00968	MTF2 (directAnnotation).
PAFAH1B2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PAFAH1B2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PAFAH1B2	cisbp__M00788	ZFY (inferredBy_Orthology).
PAFAH1B2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PAFAH1B2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PAFAH1B2	transfac_pro__M01199	TRIM28 (directAnnotation).
PAFAH1B2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PAFAH1B2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PAFAH1B2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PAFAH1B2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PAFAH1B2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PAFAH1B2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PAFAH1B2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
PAFAH1B2	transfac_pro__M07310	SP5 (directAnnotation).
PAFAH1B2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PAFAH1B2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PAFAH1B2	transfac_pro__M04893	TAF1 (directAnnotation).
PAFAH1B2	transfac_pro__M04817	ZBTB33 (directAnnotation).
PAFAH1B2	transfac_pro__M12697	ZNF142 (directAnnotation).
PAFAH1B2	tfdimers__MD00364	WT1 (directAnnotation).
PAFAH1B2	transfac_pro__M04916	TAF1 (directAnnotation).
PAFAH1B2	transfac_pro__M01973	PLAG1 (directAnnotation).
PAFAH1B2	tfdimers__MD00483	ZBTB14 (directAnnotation).
PAFAH1B2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PAFAH1B2	metacluster_143.13	ZBTB7A (directAnnotation).
PAFAH1B2	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
PAFAH1B2	transfac_pro__M02898	SMAD3 (directAnnotation).
PAFAH1B2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
PAFAH1B2	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PAFAH1B2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."