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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAFAH1B1

Summary for PAFAH1B1

Gene information	Gene symbol	PAFAH1B1
	Ensembl ID	ENSG00000007168
	Entrez ID	5048
	Gene name	platelet activating factor acetylhydrolase 1b regulatory subunit 1
	Synonyms	LIS1\|MDCR\|MDS\|NudF\|PAFAH
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PAFAH1B1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.35149	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.273335	1.83e-09

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Expression of PAFAH1B1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAFAH1B1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAFAH1B1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAFAH1B1	hsa-miR-3646	99.5396	NM_000430
PAFAH1B1	hsa-miR-6838-5p	96.8369	NM_000430
PAFAH1B1	hsa-miR-497-5p	95.7044	NM_000430
PAFAH1B1	hsa-miR-592	95.6926	NM_000430
PAFAH1B1	hsa-miR-195-5p	95.6025	NM_000430
PAFAH1B1	hsa-miR-15b-5p	95.6025	NM_000430
PAFAH1B1	hsa-miR-15a-5p	95.6025	NM_000430
PAFAH1B1	hsa-miR-16-5p	95.6025	NM_000430
PAFAH1B1	hsa-miR-3662	95.1782	NM_000430
PAFAH1B1	hsa-miR-182-5p	95.1675	NM_000430
PAFAH1B1	hsa-miR-8064	95.1334	NM_000430
PAFAH1B1	hsa-miR-424-5p	95.0845	NM_000430
PAFAH1B1	hsa-miR-150-3p	94.9591	NM_000430
PAFAH1B1	hsa-miR-4297	94.5097	NM_000430
PAFAH1B1	hsa-miR-16-2-3p	93.7432	NM_000430
PAFAH1B1	hsa-miR-195-3p	93.7432	NM_000430
PAFAH1B1	hsa-miR-1207-3p	93.4967	NM_000430
PAFAH1B1	hsa-miR-505-3p	93.3765	NM_000430
PAFAH1B1	hsa-miR-6510-5p	93.2958	NM_000430
PAFAH1B1	hsa-miR-144-3p	92.9531	NM_000430
PAFAH1B1	hsa-miR-8062	92.8737	NM_000430
PAFAH1B1	hsa-miR-4697-3p	92.665	NM_000430
PAFAH1B1	hsa-miR-3148	92.559	NM_000430
PAFAH1B1	hsa-miR-4666a-3p	92.302	NM_000430
PAFAH1B1	hsa-miR-4319	91.9936	NM_000430
PAFAH1B1	hsa-miR-5003-3p	91.9756	NM_000430
PAFAH1B1	hsa-miR-96-5p	91.5971	NM_000430
PAFAH1B1	hsa-miR-4666a-5p	91.4444	NM_000430
PAFAH1B1	hsa-miR-371b-3p	91.3039	NM_000430
PAFAH1B1	hsa-miR-520d-5p	91.2852	NM_000430
PAFAH1B1	hsa-miR-524-5p	91.2852	NM_000430
PAFAH1B1	hsa-miR-519e-3p	91.0011	NM_000430
PAFAH1B1	hsa-miR-33b-3p	91.0011	NM_000430
PAFAH1B1	hsa-miR-515-3p	91.0011	NM_000430
PAFAH1B1	hsa-miR-548c-3p	90.6936	NM_000430
PAFAH1B1	hsa-miR-18b-3p	90.5423	NM_000430
PAFAH1B1	hsa-miR-125b-5p	90.5035	NM_000430
PAFAH1B1	hsa-miR-125a-5p	90.5035	NM_000430
PAFAH1B1	hsa-miR-759	90.152	NM_000430
PAFAH1B1	hsa-miR-216b-3p	90.032	NM_000430
PAFAH1B1	hsa-miR-101-3p	89.8737	NM_000430
PAFAH1B1	hsa-miR-616-5p	89.6585	NM_000430
PAFAH1B1	hsa-miR-1271-5p	89.4779	NM_000430
PAFAH1B1	hsa-miR-12133	89.4779	NM_000430
PAFAH1B1	hsa-miR-4305	89.4598	NM_000430
PAFAH1B1	hsa-miR-4473	89.4257	NM_000430
PAFAH1B1	hsa-miR-525-5p	89.257	NM_000430
PAFAH1B1	hsa-miR-520a-5p	89.257	NM_000430
PAFAH1B1	hsa-miR-3670	88.7012	NM_000430
PAFAH1B1	hsa-miR-6792-5p	88.464	NM_000430

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Motifs and transcription factors (TFs) regulating PAFAH1B1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAFAH1B1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
PAFAH1B1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PAFAH1B1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PAFAH1B1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PAFAH1B1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
PAFAH1B1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PAFAH1B1	metacluster_135.11	NR2C2 (directAnnotation).
PAFAH1B1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PAFAH1B1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PAFAH1B1	metacluster_7.13	ZFX (directAnnotation).
PAFAH1B1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PAFAH1B1	cisbp__M00968	MTF2 (directAnnotation).
PAFAH1B1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PAFAH1B1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PAFAH1B1	cisbp__M00341	PAX6 (directAnnotation).
PAFAH1B1	metacluster_198.3	ZFP64 (directAnnotation).
PAFAH1B1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PAFAH1B1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PAFAH1B1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PAFAH1B1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PAFAH1B1	cisbp__M00788	ZFY (inferredBy_Orthology).
PAFAH1B1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PAFAH1B1	metacluster_175.1	ZNF283 (directAnnotation).
PAFAH1B1	hdpi__ZNF304	ZNF304 (directAnnotation).
PAFAH1B1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PAFAH1B1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PAFAH1B1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PAFAH1B1	transfac_pro__M01199	TRIM28 (directAnnotation).
PAFAH1B1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PAFAH1B1	metacluster_151.2	ZNF23 (directAnnotation).
PAFAH1B1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PAFAH1B1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PAFAH1B1	transfac_pro__M03806	ZBTB7C (directAnnotation).
PAFAH1B1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."