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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OTUD4

Summary for OTUD4

Gene information	Gene symbol	OTUD4
	Ensembl ID	ENSG00000164164
	Entrez ID	54726
	Gene name	OTU deubiquitinase 4
	Synonyms	DUBA6\|HSHIN1\|KIAA1046
	Gene type	protein_coding
	UniProtAcc	Q01804

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Dataset with differentially expressed gene: OTUD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.266401	1.94e-19

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Expression of OTUD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OTUD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OTUD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OTUD4	hsa-miR-1297	99.8405	NM_001102653
OTUD4	hsa-miR-26b-5p	99.7138	NM_001102653
OTUD4	hsa-miR-26a-5p	99.7138	NM_001102653
OTUD4	hsa-miR-186-5p	99.6813	NM_001102653
OTUD4	hsa-miR-4465	99.2625	NM_001102653
OTUD4	hsa-miR-6828-5p	98.5309	NM_001102653
OTUD4	hsa-miR-3609	97.8662	NM_001102653
OTUD4	hsa-miR-548ah-5p	97.845	NM_001102653
OTUD4	hsa-miR-4307	96.7719	NM_001102653
OTUD4	hsa-miR-4719	96.5282	NM_001102653
OTUD4	hsa-miR-3065-5p	96.48	NM_001102653
OTUD4	hsa-miR-3133	95.8994	NM_001102653
OTUD4	hsa-miR-3617-5p	95.5862	NM_001102653
OTUD4	hsa-miR-641	95.5862	NM_001102653
OTUD4	hsa-miR-340-5p	95.5539	NM_001102653
OTUD4	hsa-miR-200c-3p	95.3482	NM_001102653
OTUD4	hsa-miR-429	95.3482	NM_001102653
OTUD4	hsa-miR-200b-3p	95.3482	NM_001102653
OTUD4	hsa-miR-153-3p	95.306	NM_001102653
OTUD4	hsa-miR-5011-5p	95.0654	NM_001102653
OTUD4	hsa-miR-30e-5p	94.388	NM_001102653
OTUD4	hsa-miR-30b-5p	94.388	NM_001102653
OTUD4	hsa-miR-30a-5p	94.388	NM_001102653
OTUD4	hsa-miR-30d-5p	94.388	NM_001102653
OTUD4	hsa-miR-30c-5p	94.388	NM_001102653
OTUD4	hsa-miR-6079	94.3041	NM_001102653
OTUD4	hsa-miR-101-3p	94.1822	NM_001102653
OTUD4	hsa-miR-4478	93.9901	NM_001102653
OTUD4	hsa-miR-548av-5p	93.6841	NM_001102653
OTUD4	hsa-miR-8054	93.6841	NM_001102653
OTUD4	hsa-miR-548k	93.6841	NM_001102653
OTUD4	hsa-miR-3163	93.4524	NM_001102653
OTUD4	hsa-miR-335-3p	93.3724	NM_001102653
OTUD4	hsa-miR-4257	92.7373	NM_001102653
OTUD4	hsa-miR-4796-3p	92.5248	NM_001102653
OTUD4	hsa-let-7f-1-3p	91.4865	NM_001102653
OTUD4	hsa-let-7b-3p	91.4865	NM_001102653
OTUD4	hsa-miR-98-3p	91.4865	NM_001102653
OTUD4	hsa-let-7a-3p	91.4865	NM_001102653
OTUD4	hsa-miR-4262	91.4621	NM_001102653
OTUD4	hsa-miR-518a-5p	91.3622	NM_001102653
OTUD4	hsa-miR-527	91.3622	NM_001102653
OTUD4	hsa-miR-367-3p	91.1936	NM_001102653
OTUD4	hsa-miR-25-3p	91.1936	NM_001102653
OTUD4	hsa-miR-363-3p	91.1936	NM_001102653
OTUD4	hsa-miR-767-5p	91.1354	NM_001102653
OTUD4	hsa-miR-4261	91	NM_001102653
OTUD4	hsa-miR-183-5p	90.906	NM_017493
OTUD4	hsa-miR-892a	90.7605	NM_001102653
OTUD4	hsa-miR-6882-3p	90.6834	NM_001102653

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Motifs and transcription factors (TFs) regulating OTUD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OTUD4	metacluster_135.11	NR2C2 (directAnnotation).
OTUD4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
OTUD4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
OTUD4	metacluster_7.13	ZFX (directAnnotation).
OTUD4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
OTUD4	cisbp__M00968	MTF2 (directAnnotation).
OTUD4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
OTUD4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
OTUD4	cisbp__M00341	PAX6 (directAnnotation).
OTUD4	metacluster_198.3	ZFP64 (directAnnotation).
OTUD4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
OTUD4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
OTUD4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
OTUD4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
OTUD4	cisbp__M00788	ZFY (inferredBy_Orthology).
OTUD4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
OTUD4	metacluster_175.1	ZNF283 (directAnnotation).
OTUD4	hdpi__ZNF304	ZNF304 (directAnnotation).
OTUD4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
OTUD4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
OTUD4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
OTUD4	transfac_pro__M01199	TRIM28 (directAnnotation).
OTUD4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
OTUD4	metacluster_151.2	ZNF23 (directAnnotation).
OTUD4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
OTUD4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
OTUD4	transfac_pro__M03806	ZBTB7C (directAnnotation).
OTUD4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."