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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NRP1

Summary for NRP1

Gene information	Gene symbol	NRP1
	Ensembl ID	ENSG00000099250
	Entrez ID	8829
	Gene name	neuropilin 1
	Synonyms	CD304\|NRP\|VEGF165R
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NRP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.630647	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.50362	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.277537	3.99e-22
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.251736	9.29e-04
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.428856	1.97e-30

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Expression of NRP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NRP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NRP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NRP1	hsa-miR-3646	98.0154	NM_003873
NRP1	hsa-miR-7977	97.4926	NM_003873
NRP1	hsa-miR-6844	95.8508	NM_003873
NRP1	hsa-miR-153-5p	95.348	NM_003873
NRP1	hsa-miR-3133	95.2511	NM_003873
NRP1	hsa-miR-506-3p	95.2287	NM_003873
NRP1	hsa-miR-124-3p	95.2287	NM_003873
NRP1	hsa-miR-5094	94.7606	NM_003873
NRP1	hsa-miR-148a-3p	94.1534	NM_003873
NRP1	hsa-miR-152-3p	94.1534	NM_003873
NRP1	hsa-miR-148b-3p	94.1534	NM_003873
NRP1	hsa-miR-3148	93.7263	NM_003873
NRP1	hsa-miR-5006-3p	93.5895	NM_003873
NRP1	hsa-miR-4755-5p	93.5895	NM_003873
NRP1	hsa-miR-548an	93.1306	NM_003873
NRP1	hsa-miR-3686	92.8887	NM_003873
NRP1	hsa-miR-651-3p	92.8322	NM_003873
NRP1	hsa-miR-1285-3p	92.566	NM_003873
NRP1	hsa-miR-5189-5p	92.566	NM_003873
NRP1	hsa-miR-206	92.4559	NM_003873
NRP1	hsa-miR-1-3p	92.4559	NM_003873
NRP1	hsa-miR-3187-5p	91.9358	NM_003873
NRP1	hsa-miR-6860	91.9358	NM_003873
NRP1	hsa-miR-612	91.9358	NM_003873
NRP1	hsa-miR-5004-5p	91.7313	NM_003873
NRP1	hsa-let-7a-3p	91.6596	NM_003873
NRP1	hsa-let-7f-1-3p	91.6596	NM_003873
NRP1	hsa-let-7b-3p	91.6596	NM_003873
NRP1	hsa-miR-98-3p	91.6596	NM_003873
NRP1	hsa-miR-510-3p	91.0073	NM_003873
NRP1	hsa-miR-338-3p	90.4972	NM_003873
NRP1	hsa-miR-613	90.1557	NM_003873
NRP1	hsa-miR-1322	90.0711	NM_003873
NRP1	hsa-miR-9-5p	89.9458	NM_003873
NRP1	hsa-miR-6806-3p	89.6695	NM_003873
NRP1	hsa-miR-3928-5p	89.6695	NM_003873
NRP1	hsa-miR-320a-3p	89.6223	NM_003873
NRP1	hsa-miR-320c	89.6223	NM_003873
NRP1	hsa-miR-320b	89.6223	NM_003873
NRP1	hsa-miR-320d	89.6223	NM_003873
NRP1	hsa-miR-4429	89.6223	NM_003873
NRP1	hsa-miR-4261	88.99	NM_003873
NRP1	hsa-miR-150-3p	88.6379	NM_003873
NRP1	hsa-miR-6733-3p	88.4918	NM_003873
NRP1	hsa-miR-5701	87.5375	NM_003873
NRP1	hsa-miR-4724-5p	87.4577	NM_003873
NRP1	hsa-miR-4251	87.4043	NM_003873
NRP1	hsa-miR-3920	86.8911	NM_003873
NRP1	hsa-miR-147b-5p	86.7972	NM_003873
NRP1	hsa-miR-4789-5p	85.7781	NM_003873

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Motifs and transcription factors (TFs) regulating NRP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NRP1	transfac_pro__M06140	ZNF250 (directAnnotation).
NRP1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
NRP1	transfac_pro__M06035	ZNF749 (directAnnotation).
NRP1	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
NRP1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
NRP1	metacluster_52.11	ZNF184 (directAnnotation).
NRP1	metacluster_135.11	NR2C2 (directAnnotation).
NRP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NRP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NRP1	cisbp__M00968	MTF2 (directAnnotation).
NRP1	cisbp__M00341	PAX6 (directAnnotation).
NRP1	metacluster_198.3	ZFP64 (directAnnotation).
NRP1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
NRP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NRP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NRP1	metacluster_175.1	ZNF283 (directAnnotation).
NRP1	hdpi__ZNF304	ZNF304 (directAnnotation).
NRP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NRP1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
NRP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NRP1	transfac_pro__M01199	TRIM28 (directAnnotation).
NRP1	metacluster_151.2	ZNF23 (directAnnotation).
NRP1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NRP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NRP1	transfac_pro__M03806	ZBTB7C (directAnnotation).
NRP1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NRP1	transfac_pro__M07260	IKZF1 (directAnnotation).
NRP1	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
NRP1	transfac_pro__M01835	KLF4 (directAnnotation).
NRP1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
NRP1	swissregulon__hs__MTA3	MTA3 (directAnnotation).
NRP1	transfac_pro__M07270	TEAD4 (directAnnotation).
NRP1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NRP1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
NRP1	transfac_pro__M02089	E2F3 (directAnnotation).
NRP1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NRP1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NRP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
NRP1	tfdimers__MD00483	ZBTB14 (directAnnotation).
NRP1	cisbp__M07938	E2F1 (directAnnotation).
NRP1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NRP1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NRP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NRP1	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."