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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MTF2

Summary for MTF2

Gene information	Gene symbol	MTF2
	Ensembl ID	ENSG00000143033
	Entrez ID	22823
	Gene name	metal response element binding transcription factor 2
	Synonyms	M96\|PCL2\|TDRD19A
	Gene type	protein_coding
	UniProtAcc	Q9Y483

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Dataset with differentially expressed gene: MTF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.402379	4.25e-22
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.340195	2.79e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.44957	0.00e+00

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Expression of MTF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MTF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MTF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MTF2	hsa-miR-6505-5p	99.7324	NM_001164391
MTF2	hsa-miR-409-3p	99.5011	NM_001164391
MTF2	hsa-miR-5011-5p	97.7886	NM_007358
MTF2	hsa-miR-543	96.8425	NM_001164391
MTF2	hsa-miR-181b-5p	96.3598	NM_001164391
MTF2	hsa-miR-181c-5p	96.3598	NM_001164391
MTF2	hsa-miR-181a-5p	96.3598	NM_001164391
MTF2	hsa-miR-181d-5p	96.3598	NM_001164391
MTF2	hsa-miR-34b-3p	95.9889	NM_001164391
MTF2	hsa-miR-33a-3p	95.6747	NM_001164391
MTF2	hsa-miR-4262	95.4854	NM_001164391
MTF2	hsa-miR-132-3p	95.1309	NM_007358
MTF2	hsa-miR-212-3p	95.1309	NM_007358
MTF2	hsa-miR-8485	94.7773	NM_007358
MTF2	hsa-miR-4325	94.5325	NM_007358
MTF2	hsa-miR-138-5p	94.4952	NM_001164391
MTF2	hsa-miR-5688	93.958	NM_007358
MTF2	hsa-miR-495-3p	93.7923	NM_007358
MTF2	hsa-miR-4263	93.6323	NM_007358
MTF2	hsa-miR-29a-5p	93.5915	NM_007358
MTF2	hsa-miR-3658	93.5632	NM_007358
MTF2	hsa-miR-1207-3p	93.2338	NM_007358
MTF2	hsa-miR-6753-3p	92.7278	NM_007358
MTF2	hsa-miR-7107-3p	92.7278	NM_007358
MTF2	hsa-miR-208b-3p	91.8938	NM_007358
MTF2	hsa-miR-208a-3p	91.8938	NM_007358
MTF2	hsa-miR-513a-3p	91.4803	NM_007358
MTF2	hsa-miR-513c-3p	91.4803	NM_007358
MTF2	hsa-miR-3606-3p	90.8154	NM_007358
MTF2	hsa-miR-602	89.6494	NM_007358
MTF2	hsa-miR-370-5p	89.512	NM_001164391
MTF2	hsa-miR-5681b	89.3179	NM_007358
MTF2	hsa-miR-1277-5p	89.0491	NM_001164391
MTF2	hsa-miR-5691	88.4294	NM_007358
MTF2	hsa-miR-6805-3p	88.4294	NM_007358
MTF2	hsa-miR-6888-5p	87.7087	NM_001164391
MTF2	hsa-miR-103a-2-5p	86.9942	NM_001164391
MTF2	hsa-miR-103a-1-5p	86.9942	NM_001164391
MTF2	hsa-miR-567	86.9287	NM_007358
MTF2	hsa-miR-450a-2-3p	86.6679	NM_007358
MTF2	hsa-miR-6728-3p	86.5891	NM_001164391
MTF2	hsa-miR-6880-5p	86.1692	NM_007358
MTF2	hsa-miR-7151-3p	86.1052	NM_001164391
MTF2	hsa-miR-449b-3p	85.9942	NM_001164391
MTF2	hsa-miR-16-2-3p	85.3854	NM_007358
MTF2	hsa-miR-195-3p	85.3854	NM_007358
MTF2	hsa-miR-5047	85.1285	NM_007358
MTF2	hsa-miR-1301-3p	85.1285	NM_007358
MTF2	hsa-miR-4438	84.3175	NM_007358
MTF2	hsa-miR-5195-5p	84.2199	NM_007358

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Motifs and transcription factors (TFs) regulating MTF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MTF2	transfac_pro__M04826	EP300 (directAnnotation).
MTF2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MTF2	hdpi__ETV4	ETV4 (directAnnotation).
MTF2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
MTF2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
MTF2	transfac_pro__M00492	STAT1 (directAnnotation).
MTF2	metacluster_141.2	E2F2; E2F3 (directAnnotation).
MTF2	transfac_pro__M04794	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MTF2	cisbp__M00968	up	Malignant cells	GSE153697	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."