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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MOB4

Summary for MOB4

Gene information	Gene symbol	MOB4
	Ensembl ID	ENSG00000115540
	Entrez ID	25843
	Gene name	MOB family member 4, phocein
	Synonyms	2C4D\|CGI-95\|DKFZP564M112\|MOB3\|MOBKL3\|PHOCN\|PREI3
	Gene type	protein_coding
	UniProtAcc	Q9Y3A3

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Dataset with differentially expressed gene: MOB4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.332391	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.350743	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.258595	6.49e-41
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.500886	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.312129	5.10e-15

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Expression of MOB4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MOB4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MOB4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MOB4	hsa-miR-101-3p	99.1162	NM_001100819
MOB4	hsa-miR-8485	97.3135	NM_001100819
MOB4	hsa-miR-548ap-3p	96.568	NM_001100819
MOB4	hsa-miR-548aa	96.568	NM_001100819
MOB4	hsa-miR-548t-3p	96.568	NM_001100819
MOB4	hsa-miR-144-3p	95.7155	NM_001100819
MOB4	hsa-miR-5011-5p	95.5733	NM_001100819
MOB4	hsa-let-7f-2-3p	95.5453	NM_001100819
MOB4	hsa-miR-1185-1-3p	95.5453	NM_001100819
MOB4	hsa-miR-1185-2-3p	95.5453	NM_001100819
MOB4	hsa-miR-548bb-3p	94.0082	NM_001100819
MOB4	hsa-miR-548ac	94.0082	NM_001100819
MOB4	hsa-miR-548z	94.0082	NM_001100819
MOB4	hsa-miR-548d-3p	94.0082	NM_001100819
MOB4	hsa-miR-548h-3p	94.0082	NM_001100819
MOB4	hsa-miR-374b-3p	93.5187	NM_001100819
MOB4	hsa-miR-2110	92.2148	NM_001100819
MOB4	hsa-miR-10395-3p	91.9883	NM_001100819
MOB4	hsa-miR-5583-3p	91.9833	NM_001100819
MOB4	hsa-miR-142-3p	91.6384	NM_001100819
MOB4	hsa-miR-4789-3p	91.5945	NM_001100819
MOB4	hsa-miR-1227-3p	90.4907	NM_001100819
MOB4	hsa-miR-3924	90.389	NM_001100819
MOB4	hsa-miR-202-3p	90.309	NM_001100819
MOB4	hsa-miR-6787-3p	90.2327	NM_001100819
MOB4	hsa-miR-4445-5p	89.9035	NM_001100819
MOB4	hsa-miR-374c-5p	88.8748	NM_001100819
MOB4	hsa-miR-655-3p	88.8748	NM_001100819
MOB4	hsa-miR-4524b-5p	88.8676	NM_001100819
MOB4	hsa-miR-4524a-5p	88.8676	NM_001100819
MOB4	hsa-miR-2053	88.7842	NM_001100819
MOB4	hsa-miR-548l	88.7459	NM_001100819
MOB4	hsa-miR-3613-3p	88.6325	NM_001100819
MOB4	hsa-miR-15b-5p	88.2356	NM_001100819
MOB4	hsa-miR-195-5p	88.2356	NM_001100819
MOB4	hsa-miR-15a-5p	88.2356	NM_001100819
MOB4	hsa-miR-16-5p	88.2356	NM_001100819
MOB4	hsa-miR-8084	87.5293	NM_001100819
MOB4	hsa-miR-578	87.4835	NM_001100819
MOB4	hsa-miR-4789-5p	87.2824	NM_001100819
MOB4	hsa-miR-5689	87.2495	NM_001100819
MOB4	hsa-miR-424-5p	86.42	NM_001100819
MOB4	hsa-miR-497-5p	86.42	NM_001100819
MOB4	hsa-miR-6838-5p	86.42	NM_001100819
MOB4	hsa-miR-4666a-3p	86.1317	NM_001100819
MOB4	hsa-miR-570-3p	84.7323	NM_001100819
MOB4	hsa-miR-3064-3p	84.0173	NM_001100819
MOB4	hsa-miR-6892-5p	83.4951	NM_001100819
MOB4	hsa-miR-3941	83.2242	NM_001100819
MOB4	hsa-miR-6826-3p	82.8914	NM_001100819

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Motifs and transcription factors (TFs) regulating MOB4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MOB4	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MOB4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MOB4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MOB4	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MOB4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MOB4	swissregulon__hs__ELF2	ELF2 (directAnnotation).
MOB4	hdpi__ETV4	ETV4 (directAnnotation).
MOB4	cisbp__M02645	ETS1 (directAnnotation).
MOB4	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MOB4	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
MOB4	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
MOB4	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MOB4	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MOB4	cisbp__M08198	ELF1 (directAnnotation).
MOB4	hdpi__TP73	TP73 (directAnnotation).
MOB4	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
MOB4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MOB4	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MOB4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MOB4	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
MOB4	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
MOB4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MOB4	metacluster_7.13	ZFX (directAnnotation).
MOB4	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
MOB4	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MOB4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MOB4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MOB4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MOB4	transfac_pro__M01303	SP1 (directAnnotation).
MOB4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MOB4	transfac_pro__M02090	E2F4 (directAnnotation).
MOB4	transfac_pro__M01714	KLF15 (directAnnotation).
MOB4	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
MOB4	transfac_pro__M02089	E2F3 (directAnnotation).
MOB4	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
MOB4	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
MOB4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
MOB4	cisbp__M07938	E2F1 (directAnnotation).
MOB4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
MOB4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MOB4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MOB4	transfac_pro__M02898	SMAD3 (directAnnotation).
MOB4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MOB4	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
MOB4	jaspar__MA1122.1	TFDP1 (directAnnotation).
MOB4	jaspar__MA0748.2	YY2 (directAnnotation).
MOB4	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MOB4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MOB4	metacluster_182.10	ZFX (directAnnotation).
MOB4	cisbp__M00788	ZFY (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."