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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MLLT3

Summary for MLLT3

Gene information	Gene symbol	MLLT3
	Ensembl ID	ENSG00000171843
	Entrez ID	4300
	Gene name	MLLT3 super elongation complex subunit
	Synonyms	AF-9\|AF9\|YEATS3
	Gene type	protein_coding
	UniProtAcc	P42568

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Dataset with differentially expressed gene: MLLT3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.511465	1.09e-20
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.868297	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.26134	6.58e-17

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Expression of MLLT3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MLLT3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MLLT3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MLLT3	hsa-miR-5011-5p	99.9994	NM_004529
MLLT3	hsa-miR-3613-3p	99.6623	NM_001286691
MLLT3	hsa-miR-4775	99.5474	NM_001286691
MLLT3	hsa-miR-3121-3p	99.486	NM_001286691
MLLT3	hsa-miR-3148	99.4576	NM_004529
MLLT3	hsa-miR-190a-3p	99.3873	NM_004529
MLLT3	hsa-miR-4446-5p	99.2154	NM_004529
MLLT3	hsa-miR-4789-3p	98.1426	NM_001286691
MLLT3	hsa-miR-1305	98.0924	NM_001286691
MLLT3	hsa-miR-548c-3p	98.0304	NM_001286691
MLLT3	hsa-miR-466	97.4295	NM_001286691
MLLT3	hsa-miR-4742-3p	97.3268	NM_004529
MLLT3	hsa-miR-34a-5p	96.1992	NM_001286691
MLLT3	hsa-miR-449a	96.1992	NM_001286691
MLLT3	hsa-miR-3662	95.822	NM_001286691
MLLT3	hsa-miR-34c-5p	95.7085	NM_001286691
MLLT3	hsa-miR-449b-5p	95.7085	NM_001286691
MLLT3	hsa-miR-4755-5p	95.1438	NM_004529
MLLT3	hsa-miR-5006-3p	95.1438	NM_004529
MLLT3	hsa-miR-320b	95.1287	NM_001286691
MLLT3	hsa-miR-4429	95.1287	NM_001286691
MLLT3	hsa-miR-320d	95.1287	NM_001286691
MLLT3	hsa-miR-320c	95.1287	NM_001286691
MLLT3	hsa-miR-320a-3p	95.1287	NM_001286691
MLLT3	hsa-miR-590-3p	94.8748	NM_001286691
MLLT3	hsa-miR-216a-5p	94.6244	NM_004529
MLLT3	hsa-miR-133b	94.3581	NM_001286691
MLLT3	hsa-miR-133a-3p	94.3581	NM_001286691
MLLT3	hsa-miR-10397-3p	93.2495	NM_001286691
MLLT3	hsa-miR-3658	93.15	NM_004529
MLLT3	hsa-miR-3529-3p	93.0418	NM_004529
MLLT3	hsa-miR-651-5p	92.5304	NM_004529
MLLT3	hsa-miR-607	92.2826	NM_001286691
MLLT3	hsa-miR-548t-3p	91.386	NM_004529
MLLT3	hsa-miR-548aa	91.386	NM_004529
MLLT3	hsa-miR-548ap-3p	91.386	NM_004529
MLLT3	hsa-miR-5002-5p	91.195	NM_001286691
MLLT3	hsa-miR-3163	90.8503	NM_001286691
MLLT3	hsa-miR-1303	90.8378	NM_004529
MLLT3	hsa-miR-20a-3p	90.7151	NM_001286691
MLLT3	hsa-miR-218-5p	89.9753	NM_001286691
MLLT3	hsa-miR-130a-5p	89.6716	NM_004529
MLLT3	hsa-miR-548bb-3p	89.3285	NM_004529
MLLT3	hsa-miR-548ac	89.3285	NM_004529
MLLT3	hsa-miR-548z	89.3285	NM_004529
MLLT3	hsa-miR-548d-3p	89.3285	NM_004529
MLLT3	hsa-miR-548h-3p	89.3285	NM_004529
MLLT3	hsa-miR-211-5p	89.103	NM_004529
MLLT3	hsa-miR-204-5p	89.103	NM_004529
MLLT3	hsa-miR-1290	88.5902	NM_004529

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Motifs and transcription factors (TFs) regulating MLLT3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MLLT3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MLLT3	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
MLLT3	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MLLT3	transfac_pro__M04862	NRF1 (directAnnotation).
MLLT3	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MLLT3	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
MLLT3	metacluster_141.4	GLIS2 (directAnnotation).
MLLT3	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MLLT3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MLLT3	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MLLT3	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
MLLT3	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MLLT3	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MLLT3	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
MLLT3	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MLLT3	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
MLLT3	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
MLLT3	transfac_pro__M04748	GABPA (directAnnotation).
MLLT3	kznf__ZNF653_Najafabadi2015_ChIP-seq	ZNF653 (directAnnotation).
MLLT3	transfac_pro__M04950	EGR1 (directAnnotation).
MLLT3	jaspar__MA1957.1	ELK1 (directAnnotation).
MLLT3	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
MLLT3	transfac_pro__M05721	ZNF235 (directAnnotation).
MLLT3	transfac_pro__M06388	ZNF677 (directAnnotation).
MLLT3	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
MLLT3	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
MLLT3	transfac_pro__M07392	PITX3 (directAnnotation).
MLLT3	metacluster_135.11	NR2C2 (directAnnotation).
MLLT3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MLLT3	cisbp__M00968	MTF2 (directAnnotation).
MLLT3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MLLT3	cisbp__M00341	PAX6 (directAnnotation).
MLLT3	metacluster_198.3	ZFP64 (directAnnotation).
MLLT3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MLLT3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MLLT3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MLLT3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MLLT3	metacluster_175.1	ZNF283 (directAnnotation).
MLLT3	hdpi__ZNF304	ZNF304 (directAnnotation).
MLLT3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MLLT3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MLLT3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
MLLT3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MLLT3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MLLT3	transfac_pro__M03806	ZBTB7C (directAnnotation).
MLLT3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."