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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MEF2D

Summary for MEF2D

Gene information	Gene symbol	MEF2D
	Ensembl ID	ENSG00000116604
	Entrez ID	4209
	Gene name	myocyte enhancer factor 2D
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q14814

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Dataset with differentially expressed gene: MEF2D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.596127	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.385115	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.322285	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.293155	5.33e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.253885	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.390545	6.59e-44

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Expression of MEF2D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MEF2D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MEF2D	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MEF2D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MEF2D	hsa-miR-6748-5p	99.4785	NM_001271629
MEF2D	hsa-miR-3529-3p	99.3615	NM_005920
MEF2D	hsa-miR-6785-5p	98.3315	NM_001271629
MEF2D	hsa-miR-4728-5p	98.3315	NM_001271629
MEF2D	hsa-miR-149-3p	97.7233	NM_001271629
MEF2D	hsa-miR-6883-5p	97.7233	NM_001271629
MEF2D	hsa-miR-8485	97.3857	NM_005920
MEF2D	hsa-miR-103a-3p	96.4885	NM_001271629
MEF2D	hsa-miR-107	96.4885	NM_001271629
MEF2D	hsa-miR-6766-3p	95.9781	NM_001271629
MEF2D	hsa-miR-4782-3p	95.9781	NM_001271629
MEF2D	hsa-miR-219a-5p	95.9781	NM_001271629
MEF2D	hsa-miR-6855-5p	95.9499	NM_001271629
MEF2D	hsa-miR-3170	94.3085	NM_001271629
MEF2D	hsa-miR-519d-5p	94.2517	NM_005920
MEF2D	hsa-miR-7-1-3p	93.7521	NM_001271629
MEF2D	hsa-miR-7-2-3p	93.7521	NM_001271629
MEF2D	hsa-miR-4789-5p	93.6392	NM_005920
MEF2D	hsa-miR-642a-5p	93.5003	NM_005920
MEF2D	hsa-miR-7110-5p	93.321	NM_005920
MEF2D	hsa-miR-32-5p	93.2354	NM_001271629
MEF2D	hsa-miR-92a-3p	93.2354	NM_001271629
MEF2D	hsa-miR-92b-3p	93.2354	NM_001271629
MEF2D	hsa-miR-5572	92.9084	NM_001271629
MEF2D	hsa-miR-6819-5p	92.0686	NM_001271629
MEF2D	hsa-miR-6132	91.723	NM_001271629
MEF2D	hsa-miR-6836-5p	91.723	NM_001271629
MEF2D	hsa-miR-6764-5p	91.5222	NM_001271629
MEF2D	hsa-miR-2115-3p	91.476	NM_001271629
MEF2D	hsa-miR-6756-5p	90.6251	NM_001271629
MEF2D	hsa-miR-6722-3p	90.2101	NM_001271629
MEF2D	hsa-miR-367-3p	90.0672	NM_001271629
MEF2D	hsa-miR-25-3p	90.0672	NM_001271629
MEF2D	hsa-miR-363-3p	90.0672	NM_001271629
MEF2D	hsa-miR-6737-5p	89.4886	NM_001271629
MEF2D	hsa-miR-6842-5p	88.6489	NM_005920
MEF2D	hsa-miR-1915-3p	88.3917	NM_001271629
MEF2D	hsa-miR-6891-5p	88.2083	NM_001271629
MEF2D	hsa-miR-4447	88.1892	NM_005920
MEF2D	hsa-miR-4441	88.122	NM_005920
MEF2D	hsa-miR-6748-3p	88.1179	NM_001271629
MEF2D	hsa-miR-541-3p	88.1079	NM_005920
MEF2D	hsa-miR-654-5p	88.1079	NM_005920
MEF2D	hsa-miR-361-5p	87.1446	NM_001271629
MEF2D	hsa-miR-1277-5p	87.0415	NM_005920
MEF2D	hsa-miR-6812-5p	86.9198	NM_001271629
MEF2D	hsa-miR-5692c	86.8308	NM_005920
MEF2D	hsa-miR-5692b	86.8308	NM_005920
MEF2D	hsa-miR-6793-5p	86.7682	NM_001271629
MEF2D	hsa-miR-1909-3p	86.498	NM_001271629

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Motifs and transcription factors (TFs) regulating MEF2D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MEF2D	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MEF2D	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MEF2D	transfac_pro__M01303	SP1 (directAnnotation).
MEF2D	transfac_pro__M07387	ZBTB7A (directAnnotation).
MEF2D	transfac_pro__M07329	SP7 (directAnnotation).
MEF2D	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MEF2D	transfac_pro__M01122	ZNF219 (directAnnotation).
MEF2D	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
MEF2D	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
MEF2D	tfdimers__MD00151	CHURC1 (directAnnotation).
MEF2D	tfdimers__MD00391	KLF4 (directAnnotation).
MEF2D	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
MEF2D	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
MEF2D	transfac_public__M00491	PATZ1 (directAnnotation).
MEF2D	transfac_pro__M07397	ZNF148 (directAnnotation).
MEF2D	transfac_pro__M07260	IKZF1 (directAnnotation).
MEF2D	transfac_pro__M01835	KLF4 (directAnnotation).
MEF2D	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
MEF2D	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
MEF2D	swissregulon__hs__MTA3	MTA3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."