Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MDFIC

Summary for MDFIC

Gene information	Gene symbol	MDFIC
	Ensembl ID	ENSG00000135272
	Entrez ID	29969
	Gene name	MyoD family inhibitor domain containing
	Synonyms	HIC\|MDFIC1
	Gene type	protein_coding
	UniProtAcc	Q9P1T7

Top

Dataset with differentially expressed gene: MDFIC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.337694	3.94e-18
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.383631	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.315847	9.91e-24
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.312899	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.424623	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.415053	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.265009	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.417489	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.322845	2.77e-27

Top

Expression of MDFIC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MDFIC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MDFIC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MDFIC	hsa-miR-302c-5p	99.2309	NM_199072
MDFIC	hsa-miR-3143	98.5202	NM_199072
MDFIC	hsa-miR-511-3p	98.4595	NM_199072
MDFIC	hsa-miR-5195-3p	97.8001	NM_001166345
MDFIC	hsa-miR-145-5p	97.132	NM_001166345
MDFIC	hsa-miR-12136	97.1179	NM_199072
MDFIC	hsa-miR-454-3p	97.0846	NM_001166345
MDFIC	hsa-miR-3646	96.5578	NM_199072
MDFIC	hsa-miR-4282	96.2529	NM_001166345
MDFIC	hsa-miR-3666	96.0351	NM_001166345
MDFIC	hsa-miR-4295	96.0351	NM_001166345
MDFIC	hsa-miR-301b-3p	96.0351	NM_001166345
MDFIC	hsa-miR-301a-3p	96.0351	NM_001166345
MDFIC	hsa-miR-130a-3p	96.0351	NM_001166345
MDFIC	hsa-miR-130b-3p	96.0351	NM_001166345
MDFIC	hsa-miR-4698	95.9431	NM_199072
MDFIC	hsa-miR-5692a	94.9326	NM_199072
MDFIC	hsa-miR-607	94.9107	NM_001166345
MDFIC	hsa-miR-548x-3p	94.4445	NM_199072
MDFIC	hsa-miR-548aj-3p	94.4445	NM_199072
MDFIC	hsa-miR-23b-3p	94.0095	NM_001166345
MDFIC	hsa-miR-23c	94.0095	NM_001166345
MDFIC	hsa-miR-23a-3p	94.0095	NM_001166345
MDFIC	hsa-miR-548am-3p	92.8872	NM_199072
MDFIC	hsa-miR-548aq-3p	92.8872	NM_199072
MDFIC	hsa-miR-548j-3p	92.8872	NM_199072
MDFIC	hsa-miR-548ae-3p	92.8872	NM_199072
MDFIC	hsa-miR-548ah-3p	92.8872	NM_199072
MDFIC	hsa-miR-5009-3p	92.5689	NM_001166345
MDFIC	hsa-miR-532-5p	91.8952	NM_199072
MDFIC	hsa-miR-448	91.5973	NM_199072
MDFIC	hsa-miR-4775	91.5093	NM_199072
MDFIC	hsa-miR-1305	90.5137	NM_001166345
MDFIC	hsa-miR-543	89.2605	NM_199072
MDFIC	hsa-miR-19b-3p	88.0959	NM_001166345
MDFIC	hsa-miR-1267	87.8723	NM_199072
MDFIC	hsa-miR-152-3p	87.4825	NM_001166345
MDFIC	hsa-miR-148a-3p	87.4825	NM_001166345
MDFIC	hsa-miR-148b-3p	87.4825	NM_001166345
MDFIC	hsa-miR-367-5p	86.0092	NM_199072
MDFIC	hsa-miR-559	85.7384	NM_199072
MDFIC	hsa-miR-4671-3p	85.5093	NM_199072
MDFIC	hsa-miR-125b-2-3p	85.2995	NM_199072
MDFIC	hsa-miR-506-5p	85.0508	NM_199072
MDFIC	hsa-miR-19a-3p	84.6083	NM_001166345
MDFIC	hsa-miR-4729	83.6691	NM_199072
MDFIC	hsa-miR-3658	83.1131	NM_199072
MDFIC	hsa-miR-513a-3p	83.0642	NM_199072
MDFIC	hsa-miR-3606-3p	83.0642	NM_199072
MDFIC	hsa-miR-513c-3p	83.0642	NM_199072

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating MDFIC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MDFIC	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MDFIC	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MDFIC	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MDFIC	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MDFIC	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
MDFIC	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MDFIC	cisbp__M02645	ETS1 (directAnnotation).
MDFIC	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
MDFIC	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MDFIC	transfac_pro__M06156	ZNF75D (directAnnotation).
MDFIC	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
MDFIC	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MDFIC	jaspar__MA1483.2	ELF2 (directAnnotation).
MDFIC	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
MDFIC	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
MDFIC	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
MDFIC	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
MDFIC	hdpi__FLI1	FLI1 (directAnnotation).
MDFIC	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MDFIC	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MDFIC	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MDFIC	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MDFIC	kznf__ZNF181_Imbeault2017_OM_RCADE	ZNF181 (directAnnotation).
MDFIC	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
MDFIC	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MDFIC	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
MDFIC	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
MDFIC	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
MDFIC	taipale_tf_pairs__ETV2_GSC2_RSCGGAANNNNNGGATTA_CAP_repr	ETV2; GSC2 (directAnnotation).
MDFIC	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
MDFIC	jaspar__MA1946.1	FOXI1 (directAnnotation).
MDFIC	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
MDFIC	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MDFIC	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MDFIC	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MDFIC	transfac_pro__M02090	E2F4 (directAnnotation).
MDFIC	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MDFIC	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
MDFIC	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
MDFIC	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
MDFIC	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MDFIC	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
MDFIC	transfac_pro__M01837	KLF11 (directAnnotation).
MDFIC	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MDFIC	metacluster_163.2	ZNF682 (directAnnotation).
MDFIC	transfac_pro__M00938	E2F1 (directAnnotation).
MDFIC	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
MDFIC	transfac_pro__M03844	ELK4 (directAnnotation).
MDFIC	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MDFIC	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."