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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MAPK9

Summary for MAPK9

Gene information	Gene symbol	MAPK9
	Ensembl ID	ENSG00000050748
	Entrez ID	5601
	Gene name	mitogen-activated protein kinase 9
	Synonyms	JNK2\|p54a\|PRKM9\|SAPK
	Gene type	protein_coding
	UniProtAcc	P45984

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Dataset with differentially expressed gene: MAPK9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.254354	1.70e-16
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.548156	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.287293	1.07e-08
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.337073	2.49e-16
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.804695	0.00e+00

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Expression of MAPK9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAPK9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAPK9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAPK9	hsa-miR-619-3p	97.8058	NM_139070
MAPK9	hsa-miR-4310	97.4654	NM_139068
MAPK9	hsa-miR-510-3p	97.1154	NM_139070
MAPK9	hsa-miR-7157-5p	95.733	NM_139068
MAPK9	hsa-miR-130b-5p	95.1991	NM_001135044
MAPK9	hsa-miR-335-3p	94.8294	NM_001135044
MAPK9	hsa-miR-556-3p	94.1762	NM_139070
MAPK9	hsa-miR-3622b-3p	93.4774	NM_139068
MAPK9	hsa-miR-3622a-3p	93.4774	NM_139068
MAPK9	hsa-miR-4659a-3p	93.2861	NM_001135044
MAPK9	hsa-miR-4659b-3p	93.2861	NM_001135044
MAPK9	hsa-miR-4738-3p	93.1445	NM_139068
MAPK9	hsa-miR-7-2-3p	93.0663	NM_001135044
MAPK9	hsa-miR-7-1-3p	93.0663	NM_001135044
MAPK9	hsa-miR-10522-5p	92.1311	NM_001135044
MAPK9	hsa-miR-338-5p	91.6638	NM_139070
MAPK9	hsa-miR-3121-3p	91.5848	NM_139070
MAPK9	hsa-miR-3177-5p	91.3394	NM_139070
MAPK9	hsa-miR-616-3p	91.3377	NM_139068
MAPK9	hsa-miR-6857-3p	91.1503	NM_139068
MAPK9	hsa-miR-5692a	91.1406	NM_001135044
MAPK9	hsa-miR-6165	91.0948	NM_001135044
MAPK9	hsa-miR-3163	89.9371	NM_139068
MAPK9	hsa-miR-302e	89.8864	NM_139068
MAPK9	hsa-miR-204-5p	89.7393	NM_001135044
MAPK9	hsa-miR-211-5p	89.7393	NM_001135044
MAPK9	hsa-miR-5006-3p	89.4037	NM_001135044
MAPK9	hsa-miR-4755-5p	89.4037	NM_001135044
MAPK9	hsa-miR-4724-5p	88.5752	NM_001135044
MAPK9	hsa-miR-6875-3p	88.3154	NM_139068
MAPK9	hsa-miR-501-3p	88.158	NM_001135044
MAPK9	hsa-miR-502-3p	88.158	NM_001135044
MAPK9	hsa-miR-202-3p	87.6468	NM_139068
MAPK9	hsa-miR-3117-5p	87.6347	NM_001135044
MAPK9	hsa-miR-6770-5p	87.6347	NM_139068
MAPK9	hsa-miR-203a-3p	87.1878	NM_139068
MAPK9	hsa-miR-186-5p	86.972	NM_001135044
MAPK9	hsa-miR-4719	86.4408	NM_139070
MAPK9	hsa-miR-5688	86.0597	NM_001135044
MAPK9	hsa-miR-302d-3p	85.8355	NM_139068
MAPK9	hsa-miR-520d-3p	85.8355	NM_139068
MAPK9	hsa-miR-302a-3p	85.8355	NM_139068
MAPK9	hsa-miR-520a-3p	85.8355	NM_139068
MAPK9	hsa-miR-302b-3p	85.8355	NM_139068
MAPK9	hsa-miR-520b-3p	85.8355	NM_139068
MAPK9	hsa-miR-520c-3p	85.8355	NM_139068
MAPK9	hsa-miR-520e-3p	85.8355	NM_139068
MAPK9	hsa-miR-372-3p	85.8355	NM_139068
MAPK9	hsa-miR-302c-3p	85.8355	NM_139068
MAPK9	hsa-miR-373-3p	85.8355	NM_139068

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Motifs and transcription factors (TFs) regulating MAPK9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAPK9	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MAPK9	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MAPK9	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MAPK9	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MAPK9	jaspar__MA1483.2	ELF2 (directAnnotation).
MAPK9	transfac_pro__M04826	EP300 (directAnnotation).
MAPK9	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MAPK9	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MAPK9	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MAPK9	cisbp__M08198	ELF1 (directAnnotation).
MAPK9	hdpi__ETV4	ETV4 (directAnnotation).
MAPK9	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MAPK9	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MAPK9	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MAPK9	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MAPK9	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
MAPK9	transfac_pro__M04918	EGR1 (directAnnotation).
MAPK9	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MAPK9	jaspar__MA0502.2	NFYB (directAnnotation).
MAPK9	metacluster_7.13	ZFX (directAnnotation).
MAPK9	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MAPK9	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MAPK9	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MAPK9	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
MAPK9	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MAPK9	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
MAPK9	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MAPK9	cisbp__M02645	ETS1 (directAnnotation).
MAPK9	hdpi__FLI1	FLI1 (directAnnotation).
MAPK9	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
MAPK9	jaspar__MA1708.1	ETV7 (directAnnotation).
MAPK9	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MAPK9	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
MAPK9	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
MAPK9	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
MAPK9	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
MAPK9	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
MAPK9	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
MAPK9	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
MAPK9	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MAPK9	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
MAPK9	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MAPK9	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MAPK9	"Fostamatinib"	DB12010	small molecule
MAPK9	"N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide"	DB07020	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."