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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAP3K20

Summary for MAP3K20

Gene information	Gene symbol	MAP3K20
	Ensembl ID	ENSG00000091436
	Entrez ID	51776
	Gene name	mitogen-activated protein kinase kinase kinase 20
	Synonyms	MLK7\|MLTK\|MLTKalpha\|MLTKbeta\|MRK\|ZAK
	Gene type	protein_coding
	UniProtAcc	Q9NYL2

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Dataset with differentially expressed gene: MAP3K20

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.273611	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.335669	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.318174	6.90e-21

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Expression of MAP3K20 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAP3K20

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAP3K20

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP3K20	hsa-miR-4698	99.7263	NM_133646
MAP3K20	hsa-miR-4482-3p	98.6009	NM_133646
MAP3K20	hsa-miR-137-3p	97.2968	NM_133646
MAP3K20	hsa-miR-8063	97.0166	NM_133646
MAP3K20	hsa-miR-4294	96.9561	NM_133646
MAP3K20	hsa-miR-607	96.1613	NM_133646
MAP3K20	hsa-miR-12136	95.7402	NM_133646
MAP3K20	hsa-miR-4762-3p	95.1543	NM_133646
MAP3K20	hsa-miR-548aw	94.497	NM_133646
MAP3K20	hsa-miR-493-5p	94.1635	NM_133646
MAP3K20	hsa-miR-200a-3p	94.1587	NM_133646
MAP3K20	hsa-miR-141-3p	94.1587	NM_133646
MAP3K20	hsa-miR-6499-3p	93.7613	NM_133646
MAP3K20	hsa-miR-550a-3-5p	93.5232	NM_133646
MAP3K20	hsa-miR-550a-5p	93.5232	NM_133646
MAP3K20	hsa-miR-1271-3p	93.5232	NM_133646
MAP3K20	hsa-miR-1468-3p	93.1857	NM_133646
MAP3K20	hsa-miR-6719-3p	93.0875	NM_133646
MAP3K20	hsa-miR-548ah-5p	92.8786	NM_133646
MAP3K20	hsa-miR-3609	92.8786	NM_133646
MAP3K20	hsa-miR-7159-3p	92.8038	NM_133646
MAP3K20	hsa-miR-3646	92.7893	NM_133646
MAP3K20	hsa-miR-4760-5p	92.3979	NM_016653
MAP3K20	hsa-miR-8064	92.2178	NM_133646
MAP3K20	hsa-miR-548l	91.6015	NM_133646
MAP3K20	hsa-miR-153-5p	90.2603	NM_133646
MAP3K20	hsa-miR-548aj-5p	90.2202	NM_133646
MAP3K20	hsa-miR-548x-5p	90.2202	NM_133646
MAP3K20	hsa-miR-548g-5p	90.2202	NM_133646
MAP3K20	hsa-miR-548f-5p	90.2202	NM_133646
MAP3K20	hsa-miR-876-5p	90.2159	NM_133646
MAP3K20	hsa-miR-3167	90.2022	NM_133646
MAP3K20	hsa-miR-590-3p	90.128	NM_133646
MAP3K20	hsa-miR-4272	89.9388	NM_016653
MAP3K20	hsa-miR-142-5p	89.6349	NM_133646
MAP3K20	hsa-miR-6516-3p	89.6021	NM_133646
MAP3K20	hsa-miR-548e-5p	89.5285	NM_133646
MAP3K20	hsa-miR-8061	89.4715	NM_016653
MAP3K20	hsa-miR-4495	89.1225	NM_133646
MAP3K20	hsa-miR-6071	88.6704	NM_133646
MAP3K20	hsa-miR-5011-5p	88.4638	NM_133646
MAP3K20	hsa-miR-141-5p	88.3946	NM_133646
MAP3K20	hsa-miR-4251	88.2944	NM_133646
MAP3K20	hsa-miR-130a-3p	88.2337	NM_133646
MAP3K20	hsa-miR-130b-3p	88.2337	NM_133646
MAP3K20	hsa-miR-4282	88.1705	NM_133646
MAP3K20	hsa-miR-5590-3p	88.1002	NM_133646
MAP3K20	hsa-miR-548n	87.9194	NM_133646
MAP3K20	hsa-miR-92b-3p	87.73	NM_133646
MAP3K20	hsa-miR-32-5p	87.73	NM_133646

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Motifs and transcription factors (TFs) regulating MAP3K20

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."