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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MANEA

Summary for MANEA

Gene information	Gene symbol	MANEA
	Ensembl ID	ENSG00000172469
	Entrez ID	79694
	Gene name	mannosidase endo-alpha
	Synonyms	FLJ12838\|mandaselin
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MANEA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.251591	1.84e-04

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Expression of MANEA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MANEA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MANEA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MANEA	hsa-miR-380-3p	98.8729	NM_024641
MANEA	hsa-miR-5002-5p	98.8385	NM_024641
MANEA	hsa-miR-335-3p	98.6354	NM_024641
MANEA	hsa-miR-3163	97.5335	NM_024641
MANEA	hsa-miR-944	97.4447	NM_024641
MANEA	hsa-miR-3662	97.2974	NM_024641
MANEA	hsa-miR-4452	95.3956	NM_024641
MANEA	hsa-miR-4775	95.1472	NM_024641
MANEA	hsa-miR-183-3p	94.1982	NM_024641
MANEA	hsa-miR-548c-3p	93.8287	NM_024641
MANEA	hsa-miR-670-3p	93.4505	NM_024641
MANEA	hsa-miR-6875-3p	92.8475	NM_024641
MANEA	hsa-miR-656-3p	92.3396	NM_024641
MANEA	hsa-miR-5692a	91.554	NM_024641
MANEA	hsa-miR-186-5p	90.1714	NM_024641
MANEA	hsa-miR-7111-3p	89.4108	NM_024641
MANEA	hsa-miR-590-3p	89.3541	NM_024641
MANEA	hsa-miR-3183	89.1742	NM_024641
MANEA	hsa-miR-4723-3p	89.1742	NM_024641
MANEA	hsa-miR-6769b-3p	89.1742	NM_024641
MANEA	hsa-miR-4540	89.1738	NM_024641
MANEA	hsa-miR-4495	88.6486	NM_024641
MANEA	hsa-miR-4714-5p	88.4646	NM_024641
MANEA	hsa-miR-6800-5p	87.1798	NM_024641
MANEA	hsa-miR-302e	86.6184	NM_024641
MANEA	hsa-miR-5688	86.5729	NM_024641
MANEA	hsa-miR-340-5p	86.5521	NM_024641
MANEA	hsa-miR-6509-5p	85.9269	NM_024641
MANEA	hsa-miR-6516-3p	85.2889	NM_024641
MANEA	hsa-miR-545-5p	85	NM_024641
MANEA	hsa-miR-1265	84.9986	NM_024641
MANEA	hsa-miR-3663-5p	84.7637	NM_024641
MANEA	hsa-miR-4499	84.7602	NM_024641
MANEA	hsa-miR-4307	84.4262	NM_024641
MANEA	hsa-miR-5003-5p	84.2168	NM_024641
MANEA	hsa-miR-625-3p	83.2459	NM_024641
MANEA	hsa-miR-495-3p	83.0113	NM_024641
MANEA	hsa-miR-7-2-3p	83.0113	NM_024641
MANEA	hsa-miR-7-1-3p	83.0113	NM_024641
MANEA	hsa-miR-151a-3p	82.7181	NM_024641
MANEA	hsa-miR-410-3p	82.3173	NM_024641
MANEA	hsa-miR-543	81.8988	NM_024641
MANEA	hsa-miR-548ah-3p	81.1683	NM_024641
MANEA	hsa-miR-548ae-3p	81.1683	NM_024641
MANEA	hsa-miR-548aq-3p	81.1683	NM_024641
MANEA	hsa-miR-548am-3p	81.1683	NM_024641
MANEA	hsa-miR-548j-3p	81.1683	NM_024641
MANEA	hsa-miR-1255b-2-3p	80.9614	NM_024641
MANEA	hsa-miR-3158-5p	80.8286	NM_024641
MANEA	hsa-miR-548aj-3p	80.6674	NM_024641

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Motifs and transcription factors (TFs) regulating MANEA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MANEA	transfac_pro__M06432	ZNF571 (directAnnotation).
MANEA	metacluster_35.10	ZNF681; ZNF681 (directAnnotation).
MANEA	hdpi__FLI1	FLI1 (directAnnotation).
MANEA	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
MANEA	transfac_pro__M06735	ZKSCAN7 (directAnnotation).
MANEA	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
MANEA	jaspar__MA1522.1	MAZ (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."