Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: KLF9

Summary for KLF9

Gene information	Gene symbol	KLF9
	Ensembl ID	ENSG00000119138
	Entrez ID	687
	Gene name	KLF transcription factor 9
	Synonyms	BTEB1
	Gene type	protein_coding
	UniProtAcc	Q13886

Top

Dataset with differentially expressed gene: KLF9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.69185	1.62e-05
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.253078	5.40e-05
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	0.281919	8.00e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.679348	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.262789	9.07e-25
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.260963	1.99e-33
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.321829	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.283447	3.14e-11
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.278392	1.15e-16
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.495898	1.14e-26
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.531876	0.00e+00

Top

Expression of KLF9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to KLF9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating KLF9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLF9	hsa-miR-4428	96.8247	NM_001206
KLF9	hsa-miR-216a-5p	96.8058	NM_001206
KLF9	hsa-miR-140-5p	96.6893	NM_001206
KLF9	hsa-miR-548ar-3p	94.912	NM_001206
KLF9	hsa-miR-12129	93.8007	NM_001206
KLF9	hsa-let-7c-3p	93.7453	NM_001206
KLF9	hsa-miR-548e-5p	93.6706	NM_001206
KLF9	hsa-miR-636	93.5931	NM_001206
KLF9	hsa-miR-548e-3p	93.1735	NM_001206
KLF9	hsa-miR-548bc	93.1735	NM_001206
KLF9	hsa-miR-548f-3p	93.1735	NM_001206
KLF9	hsa-miR-548az-3p	93.1735	NM_001206
KLF9	hsa-miR-548a-3p	93.1735	NM_001206
KLF9	hsa-miR-218-5p	93.1147	NM_001206
KLF9	hsa-miR-330-3p	93.0624	NM_001206
KLF9	hsa-miR-3180-5p	91.7329	NM_001206
KLF9	hsa-miR-12136	91.6443	NM_001206
KLF9	hsa-miR-758-3p	91.0348	NM_001206
KLF9	hsa-miR-4316	90.7525	NM_001206
KLF9	hsa-miR-579-3p	90.4325	NM_001206
KLF9	hsa-miR-664b-3p	90.4325	NM_001206
KLF9	hsa-miR-4520-2-3p	90.1916	NM_001206
KLF9	hsa-miR-30c-5p	89.9586	NM_001206
KLF9	hsa-miR-30d-5p	89.9586	NM_001206
KLF9	hsa-miR-30e-5p	89.9586	NM_001206
KLF9	hsa-miR-30a-5p	89.9586	NM_001206
KLF9	hsa-miR-30b-5p	89.9586	NM_001206
KLF9	hsa-miR-600	88.5812	NM_001206
KLF9	hsa-miR-6761-5p	88.5474	NM_001206
KLF9	hsa-miR-1290	88.2278	NM_001206
KLF9	hsa-miR-548az-5p	87.5223	NM_001206
KLF9	hsa-miR-548t-5p	87.5223	NM_001206
KLF9	hsa-miR-3135b	87.3121	NM_001206
KLF9	hsa-miR-4500	86.67	NM_001206
KLF9	hsa-miR-125a-3p	85.776	NM_001206
KLF9	hsa-miR-7152-5p	85.498	NM_001206
KLF9	hsa-miR-548n	84.8574	NM_001206
KLF9	hsa-miR-3613-3p	84.8118	NM_001206
KLF9	hsa-miR-4460	84.7853	NM_001206
KLF9	hsa-miR-5582-3p	84.7247	NM_001206
KLF9	hsa-miR-6507-5p	84.5992	NM_001206
KLF9	hsa-miR-5004-3p	84.5597	NM_001206
KLF9	hsa-miR-20a-3p	84.0038	NM_001206
KLF9	hsa-miR-4327	83.498	NM_001206
KLF9	hsa-miR-7157-3p	83.4294	NM_001206
KLF9	hsa-miR-6737-3p	83.4294	NM_001206
KLF9	hsa-miR-5008-3p	83.4294	NM_001206
KLF9	hsa-miR-7850-5p	83.1922	NM_001206
KLF9	hsa-miR-6830-3p	83.159	NM_001206
KLF9	hsa-let-7d-5p	82.4312	NM_001206

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating KLF9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLF9	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
KLF9	transfac_pro__M08187	ABL1 (directAnnotation).
KLF9	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
KLF9	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
KLF9	hdpi__ETS1	ETS1 (directAnnotation).
KLF9	metacluster_188.3	FOXJ3; FOXJ3; FOXP1; FOXP1 (directAnnotation). FOXO1; FOXO4; FOXP1 (inferredBy_Orthology).
KLF9	metacluster_77.11	SOX12 (directAnnotation).
KLF9	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KLF9	transfac_pro__M04617	ZBTB7A (directAnnotation).
KLF9	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
KLF9	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KLF9	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KLF9	transfac_pro__M07387	ZBTB7A (directAnnotation).
KLF9	transfac_pro__M07436	WT1 (directAnnotation).
KLF9	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
KLF9	transfac_pro__M00716	ZBTB14 (directAnnotation).
KLF9	swissregulon__hs__CHD1	CHD1 (directAnnotation).
KLF9	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
KLF9	transfac_pro__M03876	ZBTB33 (directAnnotation).
KLF9	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
KLF9	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KLF9	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KLF9	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
KLF9	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
KLF9	jaspar__MA1125.1	ZNF384 (directAnnotation).
KLF9	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
KLF9	metacluster_32.24	ZNF287 (directAnnotation).
KLF9	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
KLF9	transfac_pro__M06408	ZSCAN30 (directAnnotation).
KLF9	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
KLF9	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
KLF9	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
KLF9	tfdimers__MD00335	FOXP3; NKX2-1 (directAnnotation).
KLF9	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
KLF9	transfac_pro__M06270	ZNF468 (directAnnotation).
KLF9	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
KLF9	hdpi__TCF3	TCF3 (directAnnotation).
KLF9	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
KLF9	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
KLF9	tfdimers__MD00254	POU5F1 (directAnnotation).
KLF9	transfac_pro__M07255	FOXM1 (directAnnotation).
KLF9	cisbp__M00750	AHCTF1 (inferredBy_Orthology).
KLF9	cisbp__M00377	POU2F1 (directAnnotation).
KLF9	transfac_pro__M03559	POU1F1 (directAnnotation).
KLF9	metacluster_27.29	ZNF583 (directAnnotation). ZNF583 (inferredBy_Orthology).
KLF9	jaspar__MA0079.5	SP1 (directAnnotation).
KLF9	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
KLF9	transfac_pro__M05712	ZNF134 (directAnnotation).
KLF9	metacluster_74.6	HNF1A (directAnnotation).
KLF9	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
KLF9	metacluster_195.2	up	Malignant cells	GSE140440	NA
KLF9	transfac_pro__M07461	up	Malignant cells	GSE140440	NA

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."