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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KDSR

Summary for KDSR

Gene information	Gene symbol	KDSR
	Ensembl ID	ENSG00000119537
	Entrez ID	2531
	Gene name	3-ketodihydrosphingosine reductase
	Synonyms	DHSR\|FVT1\|SDR35C1
	Gene type	protein_coding
	UniProtAcc	Q06136

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Dataset with differentially expressed gene: KDSR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.426139	7.64e-35
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.269713	2.98e-13
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.27373	3.84e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.466546	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.70309	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.254041	0.00e+00

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Expression of KDSR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KDSR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KDSR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KDSR	hsa-miR-12136	99.9496	NM_002035
KDSR	hsa-miR-4659a-3p	99.2319	NM_002035
KDSR	hsa-miR-4659b-3p	99.2319	NM_002035
KDSR	hsa-miR-548p	98.5296	NM_002035
KDSR	hsa-miR-15a-5p	97.1294	NM_002035
KDSR	hsa-miR-16-5p	97.1294	NM_002035
KDSR	hsa-miR-15b-5p	97.1294	NM_002035
KDSR	hsa-miR-195-5p	97.1294	NM_002035
KDSR	hsa-miR-6838-5p	95.9266	NM_002035
KDSR	hsa-miR-424-5p	95.7841	NM_002035
KDSR	hsa-miR-497-5p	95.7841	NM_002035
KDSR	hsa-miR-6875-3p	95.5869	NM_002035
KDSR	hsa-miR-450b-3p	94.8478	NM_002035
KDSR	hsa-miR-769-3p	94.6438	NM_002035
KDSR	hsa-miR-8063	94.509	NM_002035
KDSR	hsa-miR-4524a-3p	94.3599	NM_002035
KDSR	hsa-miR-624-3p	92.6137	NM_002035
KDSR	hsa-miR-3680-3p	92.0174	NM_002035
KDSR	hsa-miR-5011-5p	91.916	NM_002035
KDSR	hsa-miR-4524a-5p	90.8903	NM_002035
KDSR	hsa-miR-4524b-5p	90.8903	NM_002035
KDSR	hsa-miR-153-3p	89.8477	NM_002035
KDSR	hsa-miR-10527-5p	89.6798	NM_002035
KDSR	hsa-miR-3613-3p	89.4396	NM_002035
KDSR	hsa-miR-6508-5p	88.4668	NM_002035
KDSR	hsa-miR-1299	88.3987	NM_002035
KDSR	hsa-miR-4698	88.0558	NM_002035
KDSR	hsa-miR-4668-5p	87.9431	NM_002035
KDSR	hsa-miR-4511	87.8985	NM_002035
KDSR	hsa-miR-455-5p	87.3407	NM_002035
KDSR	hsa-miR-217-3p	87.0558	NM_002035
KDSR	hsa-miR-1277-5p	86.9768	NM_002035
KDSR	hsa-miR-186-5p	86.3535	NM_002035
KDSR	hsa-miR-539-5p	86.1461	NM_002035
KDSR	hsa-miR-8067	85.6617	NM_002035
KDSR	hsa-miR-4775	85.3692	NM_002035
KDSR	hsa-miR-3679-5p	84.9215	NM_002035
KDSR	hsa-miR-448	84.8577	NM_002035
KDSR	hsa-miR-4713-3p	84.1311	NM_002035
KDSR	hsa-miR-5704	84.102	NM_002035
KDSR	hsa-miR-503-5p	83.4424	NM_002035
KDSR	hsa-miR-381-3p	83.3282	NM_002035
KDSR	hsa-miR-300	83.3282	NM_002035
KDSR	hsa-miR-1185-5p	82.9679	NM_002035
KDSR	hsa-miR-4530	81.3882	NM_002035
KDSR	hsa-miR-6128	81.0692	NM_002035
KDSR	hsa-miR-374a-3p	80.8253	NM_002035
KDSR	hsa-miR-3163	80.7841	NM_002035
KDSR	hsa-miR-380-3p	80.5595	NM_002035
KDSR	hsa-miR-5692b	80.2424	NM_002035

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Motifs and transcription factors (TFs) regulating KDSR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KDSR	metacluster_7.13	ZFX (directAnnotation).
KDSR	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KDSR	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KDSR	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
KDSR	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KDSR	metacluster_182.10	ZFX (directAnnotation).
KDSR	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
KDSR	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KDSR	metacluster_135.11	NR2C2 (directAnnotation).
KDSR	tfdimers__MD00038	TFAP2C (directAnnotation).
KDSR	cisbp__M00968	MTF2 (directAnnotation).
KDSR	metacluster_160.20	JUND; PRDM15 (directAnnotation).
KDSR	cisbp__M00341	PAX6 (directAnnotation).
KDSR	metacluster_198.3	ZFP64 (directAnnotation).
KDSR	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KDSR	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
KDSR	cisbp__M00788	ZFY (inferredBy_Orthology).
KDSR	hdpi__ZNF304	ZNF304 (directAnnotation).
KDSR	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
KDSR	transfac_pro__M01199	TRIM28 (directAnnotation).
KDSR	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KDSR	transfac_pro__M03806	ZBTB7C (directAnnotation).
KDSR	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KDSR	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KDSR	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
KDSR	transfac_pro__M06173	ZNF85 (directAnnotation).
KDSR	hdpi__ELF2	ELF2 (directAnnotation).
KDSR	swissregulon__hs__ELK1	ELK1 (directAnnotation).
KDSR	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."