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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IREB2

Summary for IREB2

Gene information	Gene symbol	IREB2
	Ensembl ID	ENSG00000136381
	Entrez ID	3658
	Gene name	iron responsive element binding protein 2
	Synonyms	IRP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: IREB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.260222	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.320936	3.39e-31

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Expression of IREB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IREB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IREB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IREB2	hsa-miR-580-5p	97.2181	NM_001320941
IREB2	hsa-miR-4766-3p	97.0159	NM_004136
IREB2	hsa-miR-1255a	96.5509	NM_004136
IREB2	hsa-miR-1255b-5p	96.5509	NM_004136
IREB2	hsa-miR-6844	95.997	NM_001320943
IREB2	hsa-miR-4666a-3p	95.8405	NM_001320941
IREB2	hsa-miR-5682	94.374	NM_001320941
IREB2	hsa-miR-4430	94.2347	NM_004136
IREB2	hsa-miR-3652	94.2347	NM_004136
IREB2	hsa-miR-3910	93.5296	NM_001320943
IREB2	hsa-miR-29c-3p	93.3383	NM_001320941
IREB2	hsa-miR-29a-3p	93.3383	NM_001320941
IREB2	hsa-miR-29b-3p	93.3383	NM_001320941
IREB2	hsa-miR-1284	92.4353	NM_001320941
IREB2	hsa-let-7b-3p	90.8592	NM_001320941
IREB2	hsa-let-7a-3p	90.8592	NM_001320941
IREB2	hsa-miR-98-3p	90.8592	NM_001320941
IREB2	hsa-let-7f-1-3p	90.8592	NM_001320941
IREB2	hsa-miR-4463	90.4214	NM_004136
IREB2	hsa-miR-4698	89.8145	NM_001320941
IREB2	hsa-miR-548ar-3p	88.9591	NM_001320941
IREB2	hsa-miR-6516-5p	88.2763	NM_004136
IREB2	hsa-miR-1468-3p	87.6209	NM_004136
IREB2	hsa-miR-548a-3p	87.4093	NM_001320941
IREB2	hsa-miR-548f-3p	87.4093	NM_001320941
IREB2	hsa-miR-656-3p	87.2013	NM_004136
IREB2	hsa-miR-6871-3p	87.1068	NM_001320941
IREB2	hsa-miR-5197-5p	86.2969	NM_004136
IREB2	hsa-miR-548az-3p	86.2885	NM_001320941
IREB2	hsa-miR-548e-3p	86.2885	NM_001320941
IREB2	hsa-miR-548bc	86.2885	NM_001320941
IREB2	hsa-miR-935	86.0291	NM_004136
IREB2	hsa-miR-4699-3p	85.1512	NM_001320941
IREB2	hsa-miR-676-5p	84.5647	NM_004136
IREB2	hsa-miR-6842-3p	84.2698	NM_004136
IREB2	hsa-miR-5692a	84.173	NM_004136
IREB2	hsa-miR-7-1-3p	83.8135	NM_004136
IREB2	hsa-miR-7-2-3p	83.8135	NM_004136
IREB2	hsa-miR-124-3p	83.4692	NM_001320943
IREB2	hsa-miR-506-3p	83.4692	NM_001320943
IREB2	hsa-miR-767-5p	83.1743	NM_001320941
IREB2	hsa-miR-551b-5p	83.1611	NM_001320941
IREB2	hsa-miR-4703-5p	83.0337	NM_004136
IREB2	hsa-miR-140-3p	82.5103	NM_004136
IREB2	hsa-miR-5193	82.1912	NM_004136
IREB2	hsa-miR-5001-3p	82.0635	NM_004136
IREB2	hsa-miR-3143	81.875	NM_004136
IREB2	hsa-miR-511-3p	81.646	NM_004136
IREB2	hsa-miR-6744-5p	81.5535	NM_004136
IREB2	hsa-miR-6771-3p	81.3201	NM_004136

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Motifs and transcription factors (TFs) regulating IREB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IREB2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
IREB2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
IREB2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."