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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: IKZF2

Summary for IKZF2

Gene information	Gene symbol	IKZF2
	Ensembl ID	ENSG00000030419
	Entrez ID	22807
	Gene name	IKAROS family zinc finger 2
	Synonyms	Helios\|ZNFN1A2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: IKZF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.263624	9.91e-05

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Expression of IKZF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IKZF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IKZF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IKZF2	hsa-miR-5011-5p	99.9993	NM_001079526
IKZF2	hsa-miR-190a-3p	99.9986	NM_001079526
IKZF2	hsa-miR-548aj-3p	99.9623	NM_001079526
IKZF2	hsa-miR-548x-3p	99.9623	NM_001079526
IKZF2	hsa-miR-548j-3p	99.9429	NM_001079526
IKZF2	hsa-miR-548ae-3p	99.9347	NM_001079526
IKZF2	hsa-miR-548aq-3p	99.9347	NM_001079526
IKZF2	hsa-miR-548ah-3p	99.9229	NM_001079526
IKZF2	hsa-miR-548am-3p	99.9229	NM_001079526
IKZF2	hsa-miR-6885-3p	99.5932	NM_016260
IKZF2	hsa-miR-302e	99.2723	NM_001079526
IKZF2	hsa-miR-944	99.1826	NM_001079526
IKZF2	hsa-miR-548c-3p	99.1761	NM_001079526
IKZF2	hsa-miR-4495	98.9432	NM_001079526
IKZF2	hsa-miR-5692a	98.9363	NM_001079526
IKZF2	hsa-miR-519d-5p	98.906	NM_001079526
IKZF2	hsa-miR-548ac	98.7832	NM_001079526
IKZF2	hsa-miR-548h-3p	98.7832	NM_001079526
IKZF2	hsa-miR-548z	98.7832	NM_001079526
IKZF2	hsa-miR-548bb-3p	98.7832	NM_001079526
IKZF2	hsa-miR-548d-3p	98.7832	NM_001079526
IKZF2	hsa-miR-3163	98.7334	NM_001079526
IKZF2	hsa-miR-4659b-3p	98.5716	NM_001079526
IKZF2	hsa-miR-4659a-3p	98.5716	NM_001079526
IKZF2	hsa-miR-6875-3p	98.3276	NM_001079526
IKZF2	hsa-let-7f-2-3p	98.2687	NM_016260
IKZF2	hsa-miR-1185-1-3p	98.2687	NM_016260
IKZF2	hsa-miR-1185-2-3p	98.2687	NM_016260
IKZF2	hsa-miR-548as-5p	98.0778	NM_001079526
IKZF2	hsa-miR-302d-3p	98.0739	NM_001079526
IKZF2	hsa-miR-302a-3p	98.0739	NM_001079526
IKZF2	hsa-miR-302c-3p	98.0739	NM_001079526
IKZF2	hsa-miR-302b-3p	98.0739	NM_001079526
IKZF2	hsa-miR-519c-3p	98.0056	NM_001079526
IKZF2	hsa-miR-519b-3p	98.0056	NM_001079526
IKZF2	hsa-miR-519a-3p	98.0056	NM_001079526
IKZF2	hsa-miR-1183	97.8607	NM_001079526
IKZF2	hsa-miR-3662	97.8422	NM_001079526
IKZF2	hsa-miR-559	97.5229	NM_001079526
IKZF2	hsa-miR-520c-3p	97.4853	NM_001079526
IKZF2	hsa-miR-520e-3p	97.4853	NM_001079526
IKZF2	hsa-miR-520b-3p	97.4853	NM_001079526
IKZF2	hsa-miR-186-5p	97.3563	NM_016260
IKZF2	hsa-miR-372-3p	97.3303	NM_001079526
IKZF2	hsa-miR-520a-3p	97.3303	NM_001079526
IKZF2	hsa-miR-520d-3p	97.3303	NM_001079526
IKZF2	hsa-miR-548ar-5p	97.2713	NM_001079526
IKZF2	hsa-miR-548am-5p	97.2713	NM_001079526
IKZF2	hsa-miR-548j-5p	97.2713	NM_001079526
IKZF2	hsa-miR-548h-5p	97.2713	NM_001079526

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Motifs and transcription factors (TFs) regulating IKZF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
IKZF2	tfdimers__MD00029	up	CD4+ T cells	GSE207422_Sin	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."